Adipogenesis genes (WP447)

Mus musculus

The different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.


Mary-Elizabeth Patti , Kristina Hanspers , Martijn Van Iersel , Claudio Villanueva Ph.D. , Martina Summer-Kutmon , and Egon Willighagen


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Mus musculus



Pathway Ontology

signaling pathway pertinent to development


Label Type Compact URI Comment
Frzb GeneProduct ncbigene:20378
Mixl1 GeneProduct ncbigene:27217
Wnt10b GeneProduct ncbigene:22410
Ncor1 GeneProduct ncbigene:20185
Ebf1 GeneProduct ncbigene:13591
Nr2f1 GeneProduct ncbigene:13865
Fzd1 GeneProduct ncbigene:14362
Ins2 GeneProduct ncbigene:16334
Irs4 GeneProduct ncbigene:16370
Wnt1 GeneProduct ncbigene:22408
Adpn GeneProduct ncbigene:116939
Srebf1 GeneProduct ncbigene:20787
Irs3 GeneProduct ncbigene:16369
Hif1a GeneProduct ncbigene:15251
Rxrg GeneProduct ncbigene:20183
Rxra GeneProduct ncbigene:20181
Cebpa GeneProduct ncbigene:12606
Nsg1 GeneProduct ncbigene:18196
Sp1 GeneProduct ncbigene:20683
Bmp1 GeneProduct ncbigene:12153
Cebpb GeneProduct ncbigene:12608
Catnb GeneProduct ncbigene:12387
Gadd45b GeneProduct ncbigene:17873
Tcf1 GeneProduct ncbigene:21405
Zmpste24 GeneProduct ncbigene:230709
Epas1 GeneProduct ncbigene:13819
Trib3 GeneProduct ncbigene:228775
Ncoa1 GeneProduct ncbigene:17977
Nrip1 GeneProduct ncbigene:268903
Ncor2 GeneProduct ncbigene:20602
Agt GeneProduct ncbigene:11606
Lep GeneProduct ncbigene:16846
Bscl2 GeneProduct ncbigene:14705
Slc2a4 GeneProduct ncbigene:20528
Lmna GeneProduct ncbigene:16905
Bmp2 GeneProduct ncbigene:12156
Rora GeneProduct ncbigene:19883
E2f1 GeneProduct ncbigene:13555
Bmp4 GeneProduct ncbigene:12159
Gata4 GeneProduct ncbigene:14463
Gdf10 GeneProduct ncbigene:14560
Lif GeneProduct ncbigene:16878
Ddit3 GeneProduct ncbigene:13198
Lipe GeneProduct ncbigene:16890
Creb1 GeneProduct ncbigene:12912
Ptgis GeneProduct ncbigene:19223
Lifr GeneProduct ncbigene:16880
Gadd45a GeneProduct ncbigene:13197
Dvl1 GeneProduct ncbigene:13542
Fas GeneProduct ncbigene:14102
D10Ertd214e GeneProduct ncbigene:52637
Klf7 GeneProduct ncbigene:93691
Ahr GeneProduct ncbigene:11622
Mif GeneProduct ncbigene:17319
Retn GeneProduct ncbigene:57264
Agpat2 GeneProduct ncbigene:67512
Stat5b GeneProduct ncbigene:20851
Cntfr GeneProduct ncbigene:12804
Pck1 GeneProduct ncbigene:18534
Cugbp1 GeneProduct ncbigene:13046
Stat2 GeneProduct ncbigene:20847
Klf15 GeneProduct ncbigene:66277
Foxc2 GeneProduct ncbigene:14234
Rbl2 GeneProduct ncbigene:19651
Serpine1 GeneProduct ncbigene:18787
Klf5 GeneProduct ncbigene:12224
Mef2c GeneProduct ncbigene:17260
Rb1 GeneProduct ncbigene:19645
Stat3 GeneProduct ncbigene:20848
Ndn GeneProduct ncbigene:17984
Bmp3 GeneProduct ncbigene:110075
Gata2 GeneProduct ncbigene:14461
Smad3 GeneProduct ncbigene:17127
Adn GeneProduct ncbigene:11537
Cyp26b1 GeneProduct ncbigene:232174
Stat6 GeneProduct ncbigene:20852
Il6 GeneProduct ncbigene:16193
Spock1 GeneProduct ncbigene:20745
Gh GeneProduct ncbigene:14599
Tgfb1 GeneProduct ncbigene:21803
Adipoq GeneProduct ncbigene:11450
Id3 GeneProduct ncbigene:15903
Wnt5b GeneProduct ncbigene:22419
Egr2 GeneProduct ncbigene:13654
Pbef1 GeneProduct ncbigene:59027
Gata3 GeneProduct ncbigene:14462
Mbnl1 GeneProduct ncbigene:56758
Agrp GeneProduct ncbigene:11604
Adfp GeneProduct ncbigene:11520
Twist1 GeneProduct ncbigene:22160
Stat1 GeneProduct ncbigene:20846
Rbl1 GeneProduct ncbigene:19650
Pparg GeneProduct ncbigene:19016
Wwtr1 GeneProduct ncbigene:97064
Nr1h3 GeneProduct ncbigene:22259
Cebpd GeneProduct ensembl:ENSMUSG00000071637
E2f4 GeneProduct ncbigene:104394
Nr3c1 GeneProduct ncbigene:14815
Tnf GeneProduct ncbigene:21926
Klf6 GeneProduct ncbigene:23849
Ppara GeneProduct ncbigene:19013
Sfrp4 GeneProduct ncbigene:20379
Lpl GeneProduct ncbigene:16956
Lpin2 GeneProduct ncbigene:64898
Ncoa2 GeneProduct ncbigene:17978
Lpin1 GeneProduct ncbigene:14245
Dlk1 GeneProduct ncbigene:13386
Osm GeneProduct ncbigene:18413
Il6st GeneProduct ncbigene:16195
Ppargc1a GeneProduct ncbigene:19017
Ins1 GeneProduct ncbigene:16333
Socs3 GeneProduct ncbigene:12702
Scd1 GeneProduct ncbigene:20249
Cyp26a1 GeneProduct ncbigene:13082
Mef2a GeneProduct ncbigene:17258
LOC384783 GeneProduct ncbigene:384783
Plin GeneProduct ncbigene:103968
Rara GeneProduct ncbigene:19401
Mef2b GeneProduct ncbigene:17259
Ppard GeneProduct ncbigene:19015
Fabp4 GeneProduct ncbigene:11770
Socs1 GeneProduct ncbigene:12703
Ucp1 GeneProduct ncbigene:22227
Igf1 GeneProduct ncbigene:16000
Foxo1 GeneProduct ncbigene:56458
Stat5a GeneProduct ncbigene:20850
Lpin3 GeneProduct ncbigene:64899
Hmga1 GeneProduct ncbigene:15361
Mef2d GeneProduct ncbigene:17261
Prlr GeneProduct ncbigene:19116
Pck2 GeneProduct ncbigene:74551
Irs1 GeneProduct ncbigene:16367
Tle3 GeneProduct ncbigene:21887


  1. Molecular regulation of adipogenesis. Rosen ED, Spiegelman BM. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia
  2. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, et al. Cell Metab. 2011 Apr 6;13(4):413–27. PubMed Europe PMC Scholia