G1 to S cell cycle control (WP445)

Danio rerio

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&


Alexander C. Zambon , Kristina Hanspers , Christine Chichester , and Marvin Martens


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Danio rerio



Pathway Ontology

G1/S DNA damage checkpoint pathway


Label Type Compact URI Comment
cdk4 GeneProduct ensembl:ENSDARG00000087937
ATM GeneProduct ncbigene:403064
mcm4 GeneProduct ncbigene:337598
myt1a GeneProduct ensembl:ENSDARG00000074030
ccne GeneProduct ncbigene:30188
cdk6 GeneProduct ensembl:ENSDARG00000070228
orc6l GeneProduct ncbigene:324256
gadd45a GeneProduct ncbigene:431763
RBL1 GeneProduct ncbigene:795522
ccne GeneProduct ncbigene:30188
zgc:77827 GeneProduct ncbigene:406479
RB1 GeneProduct ncbigene:777733
zgc:101599 GeneProduct ncbigene:450080
zgc:56598 GeneProduct ncbigene:406715
POLE GeneProduct ncbigene:553405
zgc:85821 GeneProduct ncbigene:405897
ccnb1 GeneProduct ncbigene:58025
cdkn2d GeneProduct ensembl:ENSDARG00000094176
mcm2 GeneProduct ncbigene:192338
zgc:85821 GeneProduct ncbigene:405897
cdkn2a/b GeneProduct ensembl:ENSDARG00000037262
zgc:110727 GeneProduct ncbigene:407653
tfdp2 GeneProduct ncbigene:338204
RB1 GeneProduct ncbigene:777733
ccnd3 GeneProduct ensembl:ENSDARG00000027391
mdm2 GeneProduct ncbigene:30637
zgc:55680 GeneProduct ncbigene:393141
TFDP1 GeneProduct ncbigene:393749
mcm5 GeneProduct ncbigene:286747
zgc:85772 GeneProduct ncbigene:406462
E2F5 GeneProduct ncbigene:373090
ccng2 GeneProduct ncbigene:266794
zgc:56264 GeneProduct ncbigene:406695
cdk4 GeneProduct ensembl:ENSDARG00000087937
POLE2 GeneProduct ncbigene:192320
MCM7 GeneProduct ncbigene:192333
TFDP1 GeneProduct ncbigene:393749
mcm3 GeneProduct ncbigene:192323
creb3l1 GeneProduct ensembl:ENSDARG00000015793
ccnd1 GeneProduct ensembl:ENSDARG00000101637
tp53 GeneProduct ncbigene:30590
CREB1 GeneProduct ncbigene:573207
wee1 GeneProduct ncbigene:327060
cdkn2c GeneProduct ensembl:ENSDARG00000057610
ccne GeneProduct ncbigene:30188
zgc:66452 GeneProduct ncbigene:406853
orc1l GeneProduct ncbigene:335020
rpa1 GeneProduct ncbigene:327491
ccna1 GeneProduct ncbigene:404206
prim1 GeneProduct ncbigene:30440
CDKN1A GeneProduct ncbigene:100151416
zgc:86724 GeneProduct ncbigene:415165
E2F1 GeneProduct ensembl:ENSDARG00000103868
zgc:114132 GeneProduct ncbigene:541325
ccnd2a GeneProduct ensembl:ENSDARG00000051748
cdk6 GeneProduct ensembl:ENSDARG00000070228
ccnd2b GeneProduct ensembl:ENSDARG00000070408
zgc:56310 GeneProduct ncbigene:393196
RB1 GeneProduct ncbigene:777733
orc3l GeneProduct ncbigene:334315
cdkn1ca GeneProduct ensembl:ENSDARG00000010878
rpa2 GeneProduct ncbigene:65226
MCM6 GeneProduct ncbigene:566409
zgc:77841 GeneProduct ncbigene:322059
CDKN1B GeneProduct ncbigene:368329
E2F2 GeneProduct ensembl:ENSDARG00000079233
pcna GeneProduct ncbigene:30678
e2f3 GeneProduct ensembl:ENSDARG00000070463
tp53 GeneProduct ncbigene:30590
E2F4 GeneProduct ncbigene:406741


  1. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia