miRNA degrading enzymes (WP4316)

Homo sapiens

MicroRNAs (miRNAs) are short RNAs that are important for the regulation of numerous biological processes. Accordingly, the expression of miRNAs is itself tightly controlled by mechanisms acting at the level of transcription as well as processing of miRNA precursors. Recently, active degradation of mature miRNAs has been identified as another mechanism that is important for miRNA homeostasis. In cultured human cells, ribosomal RNA processing protein 41 (RRP41) and polynucleotide phosphorylase (PNPT1) degrade specific miRNAs in the 3'-to-5'direction. (Adapted from Großhans H. et al 2012.)


Amadeo and Kristina Hanspers


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Homo sapiens



Pathway Ontology

microRNA pathway


Label Type Compact URI Comment
RRP41 GeneProduct uniprot:Q9NPD3
PNPT1 GeneProduct ensembl:ENSG00000138035
XRN1 GeneProduct ensembl:ENSG00000114127


  1. MicroRNA degradation and turnover: regulating the regulators. Zhang Z, Qin YW, Brewer G, Jing Q. Wiley Interdiscip Rev RNA. 2012;3(4):593–600. PubMed Europe PMC Scholia
  2. MicroRNA turnover: when, how, and why. Rüegger S, Großhans H. Trends Biochem Sci. 2012 Oct;37(10):436–46. PubMed Europe PMC Scholia