Ketone bodies synthesis and degradation (WP427)

Caenorhabditis elegans

Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: [[wikipedia:Ketone_bodies|Wikipedia]]


Niradiz Reyes , Thomas Kelder , Daniela Digles , Egon Willighagen , Kristina Hanspers , and Eric Weitz


last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.


Caenorhabditis elegans



Pathway Ontology

ketone bodies metabolic pathway


Label Type Compact URI Comment
3-Hydroxy-butyrate Metabolite chebi:37054
Acetoacetate Metabolite chebi:13705
3-Hydroxy-3-methylglutaryl-CoA Metabolite chebi:11814
Acetyl-CoA Metabolite chebi:15351
Acetyl-CoA Metabolite chebi:15351
Acetoacetyl-CoA Metabolite chebi:15345
kat-1 GeneProduct ncbigene:174161
HMGCS2 GeneProduct ncbigene:
Y71G12B.10 GeneProduct ncbigene:171738
C05C10.3 GeneProduct ncbigene:174548
BDH GeneProduct ncbigene:


  1. Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. Fukao T, Lopaschuk GD, Mitchell GA. Prostaglandins Leukot Essent Fatty Acids. 2004 Mar;70(3):243–51. PubMed Europe PMC Scholia