Ethanol metabolism resulting in production of ROS by CYP2E1 (WP4268)

Rattus norvegicus

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Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes.

Authors

Ado , Marvin Martens , Friederike Ehrhart , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

Participants

Label Type Compact URI Comment
Staurosporine Metabolite chebi:57491
Fluoride Metabolite chebi:17051
Enflurane Metabolite hmdb:HMDB0014373
acetaldehyde Metabolite chebi:15343
Ethanol Metabolite chebi:16236
Halothane Metabolite chebi:5615
Vitamin C Metabolite chebi:38290
Diallyl sulfide Metabolite chebi:4489
Sevoflurane Metabolite chebi:9130
6-Hydroxychlorzoxazone Metabolite hmdb:HMDB0060998
Isoflurane Metabolite chebi:6015
NAPQI Metabolite chebi:29132
Methoxyflurane Metabolite chebi:6843
Acetaminophen Metabolite chebi:46195
Chlorzoxazone Metabolite chebi:3655
U0126 Metabolite chebi:90693
Trifluoroacetic acid Metabolite chebi:45892
Fluoride Metabolite chebi:17051
Fluoride Metabolite chebi:17051
Mapk8 GeneProduct ensembl:ENSRNOG00000020155
Cyp2e1 GeneProduct ensembl:ENSRNOG00000012458
Sp1 GeneProduct ensembl:ENSRNOG00000014084
Map2k2 GeneProduct ensembl:ENSRNOG00000020005
Maff GeneProduct ensembl:ENSRNOG00000012886
Mafg GeneProduct ensembl:ENSRNOG00000036697
Map2k1 GeneProduct ensembl:ENSRNOG00000010176
Mafk GeneProduct ensembl:ENSRNOG00000001277
Nfe2l2 GeneProduct ensembl:ENSRNOG00000001548
Sp1 GeneProduct ensembl:ENSRNOG00000014084
Nfe2l2 GeneProduct ensembl:ENSRNOG00000001548
Cyp2e1 GeneProduct ensembl:ENSRNOG00000012458
Cyp2e1 GeneProduct ensembl:ENSRNOG00000012458
Protein kinase C Protein uniprot:A0A0G2K5Q0

References

  1. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Jin M, Ande A, Kumar A, Kumar S. Cell Death Dis. 2013 Mar 21;4(3):e554. PubMed Europe PMC Scholia