Ethanol metabolism resulting in production of ROS by CYP2E1 (WP4265)

Mus musculus

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for rat and human.


Ado , Egon Willighagen , Marvin Martens , and Friederike Ehrhart


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Mus musculus



Pathway Ontology

xenobiotic metabolic pathway


Label Type Compact URI Comment
staurosporine Metabolite chebi:57491
Fluoride Metabolite chebi:17051
Enflurane Metabolite hmdb:HMDB0014373
acetaldehyde Metabolite chebi:15343
ethanol Metabolite chebi:16236
Halothane Metabolite chebi:5615
Vitamin C Metabolite chebi:38290
Diallyl sulfide Metabolite chebi:4489
Sevoflurane Metabolite chebi:9130
6-Hydroxychlorzoxazone Metabolite hmdb:HMDB0060998
Isoflurane Metabolite chebi:6015
NAPQI Metabolite chebi:29132
Methoxyflurane Metabolite chebi:6843
Acetaminophen Metabolite chebi:46195
Chlorzoxazone Metabolite chebi:3655
U0126 Metabolite chebi:90693
Trifluoroacetic acid Metabolite chebi:45892
Fluoride Metabolite chebi:17051
Fluoride Metabolite chebi:17051
Mapk8 GeneProduct ensembl:ENSMUSG00000021936
Cyp2e1 GeneProduct ensembl:ENSMUSG00000025479
Sp1 GeneProduct ensembl:ENSMUSG00000001280
Map2k2 GeneProduct ensembl:ENSMUSG00000035027
Maff GeneProduct ensembl:ENSMUSG00000042622
Mafg GeneProduct ensembl:ENSMUSG00000051510
Map2k1 GeneProduct ensembl:ENSMUSG00000004936
Mafk GeneProduct ensembl:ENSMUSG00000018143
Nfe2l2 GeneProduct ensembl:ENSMUSG00000015839
Sp1 GeneProduct ensembl:ENSMUSG00000001280
Cyp2e1 GeneProduct ensembl:ENSMUSG00000025479
Cyp2e1 GeneProduct ensembl:ENSMUSG00000025479
Nfe2l2 GeneProduct ensembl:ENSMUSG00000015839
Protein kinase C Protein uniprot:Q1MX41


  1. Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway. Jin M, Ande A, Kumar A, Kumar S. Cell Death Dis. 2013 Mar 21;4(3):e554. PubMed Europe PMC Scholia