Insulin induced PI3K-Akt and MAPK in hepatocytes (WP4229)

Rattus norvegicus

Insulin-induced P13K-Akt and MAPK network in hepatocytes. Pathway is adapted from Figure 5 in the publication by Zhang et al (2017) in the Journal of Proteome Research


Susan Coort


last edited

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Rattus norvegicus



Pathway Ontology

insulin signaling pathway

Cell Type Ontology



Label Type Compact URI Comment
Grb10 GeneProduct ensembl:ENSRNOG00000004290
IRS2 GeneProduct ensembl:ENSRNOG00000023509
mLST8 GeneProduct ensembl:ENSRNOG00000009667
BAD GeneProduct ensembl:ENSRNOG00000021147
Acly GeneProduct ensembl:ENSRNOG00000016924
ERK GeneProduct ensembl:ENSRNOG00000001849
SOS1 GeneProduct ensembl:ENSRNOG00000007106
Foxo1 GeneProduct ensembl:ENSRNOG00000013397
Gys1 GeneProduct ensembl:ENSRNOG00000020812
SHC-1 GeneProduct ensembl:ENSRNOG00000020657
RAS GeneProduct ensembl:ENSRNOG00000009338
Eif4e GeneProduct ensembl:ENSRNOG00000052343
Akt1s1 GeneProduct ensembl:ENSRNOG00000020289
IRS1 GeneProduct ensembl:ENSRNOG00000014597
S6K GeneProduct ensembl:ENSRNOG00000003919
MEK GeneProduct ensembl:ENSRNOG00000053583
Gys2 GeneProduct ensembl:ENSRNOG00000059753
TSC1 GeneProduct ensembl:ENSRNOG00000011470
FoxK1 GeneProduct ensembl:ENSRNOG00000001104
LARP1 GeneProduct ensembl:ENSRNOG00000031544
Pi3K GeneProduct ensembl:ENSRNOG00000017840
Akt GeneProduct ensembl:ENSRNOG00000028629
Rheb GeneProduct ensembl:ENSRNOG00000050578
Gsk3 GeneProduct ensembl:ENSRNOG00000020417
RSK1 GeneProduct ensembl:ENSRNOG00000042411
Raptor GeneProduct ensembl:ENSRNOG00000003821
4eBP GeneProduct ensembl:ENSRNOG00000012582
Pfkfb2 GeneProduct ensembl:ENSRNOG00000004162
RAF GeneProduct ensembl:ENSRNOG00000010153
TSC2 GeneProduct ensembl:ENSRNOG00000011375
mTOR GeneProduct ensembl:ENSRNOG00000009615
Ndrg1 GeneProduct ensembl:ENSRNOG00000007393
Rps6 GeneProduct ensembl:ENSRNOG00000007663
GRB2 GeneProduct ensembl:ENSRNOG00000003990
Insulin-1 Protein uniprot:P01322


  1. Global Phosphoproteomic Analysis of Insulin/Akt/mTORC1/S6K Signaling in Rat Hepatocytes. Zhang Y, Zhang Y, Yu Y. J Proteome Res. 2017 Aug 4;16(8):2825–35. PubMed Europe PMC Scholia