Phosphodiesterases in neuronal function (WP4222)

Homo sapiens

Authors

Friederike Ehrhart , Egon Willighagen , and Cenna Doornbos

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

Gilles de la Tourette syndrome Huntington's disease attention deficit hyperactivity disorder Alzheimer's disease Parkinson's disease schizophrenia obsessive-compulsive disorder

Pathway Ontology

glutamate signaling pathway neuron-to-neuron signaling pathways dopamine signaling pathway

Cell Type Ontology

neuron

References

1. Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE). Kitabchi AE, Wilson DB, Sharma RK. Biochem Biophys Res Commun. 1971 Aug 20;44(4):898–904. PubMed Europe PMC Scholia
2. Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo. Minami N, Suzuki Y, Yamamoto M, Kihira H, Imai E, Wada H, et al. Life Sci. 1997;61(25):PL 383-9. PubMed Europe PMC Scholia
3. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3’,5’-cyclic nucleotide phosphodiesterase. Loughney K, Hill TR, Florio VA, Uher L, Rosman GJ, Wolda SL, et al. Gene. 1998 Aug 17;216(1):139–47. PubMed Europe PMC Scholia
4. Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency. Khairallah M, Khairallah RJ, Young ME, Allen BG, Gillis MA, Danialou G, et al. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7028–33. PubMed Europe PMC Scholia
5. Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor. Kern A, Mavrikaki M, Ullrich C, Albarran-Zeckler R, Brantley AF, Smith RG. Cell. 2015 Nov 19;163(5):1176–90. PubMed Europe PMC Scholia
6. Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications. Heckman PRA, van Duinen MA, Bollen EPP, Nishi A, Wennogle LP, Blokland A, et al. Int J Neuropsychopharmacol. 2016 Apr 2;19(10):pyw030. PubMed Europe PMC Scholia