Phosphodiesterases in neuronal function (WP4222)

Homo sapiens

Phosphodiesterases are enzymes which break phosphodiester bonds and play an importan role in signaling pathways, especially in second messenger pathways which involve cyclic AMP or GMP.

Authors

Friederike Ehrhart , Egon Willighagen , Cenna Doornbos , and Kristina Hanspers

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

glutamate signaling pathway dopamine signaling pathway neuron-to-neuron signaling pathways

Disease Ontology

Alzheimer's disease Gilles de la Tourette syndrome obsessive-compulsive disorder Huntington's disease Parkinson's disease attention deficit hyperactivity disorder schizophrenia

Cell Type Ontology

neuron

Participants

Label Type Compact URI Comment
AMP Metabolite hmdb:HMDB0003540
L-Glutamate Metabolite chebi:16015
GTP Metabolite chebi:37565
Calcium Metabolite hmdb:HMDB0000464
Cyclic GMP Metabolite hmdb:HMDB0001314
GMP Metabolite hmdb:HMDB0001397
Nitric oxide Metabolite hmdb:HMDB0003378
Rolipram Metabolite chebi:104872
Caffeine Metabolite hmdb:HMDB0001847
Cilostazol Metabolite hmdb:HMDB0015297
Dopamine Metabolite hmdb:HMDB0000073
Sildenafil Metabolite hmdb:HMDB0005039
Cyclic AMP Metabolite hmdb:HMDB0000058
GRIN2A GeneProduct ensembl:ENSG00000183454
GRIN2B GeneProduct ensembl:ENSG00000273079
GRIN2C GeneProduct ensembl:ENSG00000161509
PDE1C GeneProduct ensembl:ENSG00000154678
PDE4C GeneProduct ensembl:ENSG00000105650
PDE3A GeneProduct ensembl:ENSG00000172572
NOS1 GeneProduct ensembl:ENSG00000089250
PDE8B GeneProduct ensembl:ENSG00000113231
ADCY3 GeneProduct ensembl:ENSG00000138031
ADCY1 GeneProduct ensembl:ENSG00000164742
PDE12 GeneProduct ensembl:ENSG00000174840
CREB GeneProduct ensembl:ENSG00000118260
PDE3B GeneProduct ensembl:ENSG00000152270
ADCY4 GeneProduct ensembl:ENSG00000129467
DRD1 GeneProduct ensembl:ENSG00000184845
PDE6C GeneProduct ensembl:ENSG00000095464
ADCY9 GeneProduct ensembl:ENSG00000162104
PDE6A GeneProduct ensembl:ENSG00000132915
PDE4D GeneProduct ensembl:ENSG00000113448
PDE7B GeneProduct ensembl:ENSG00000171408
PDE6B GeneProduct ensembl:ENSG00000133256
ADCY2 GeneProduct ensembl:ENSG00000078295
PDE6D GeneProduct ensembl:ENSG00000156973
PDE9A GeneProduct ensembl:ENSG00000160191
PDE2A GeneProduct ensembl:ENSG00000186642
PDE6G GeneProduct ensembl:ENSG00000185527
PDE6H GeneProduct ensembl:ENSG00000139053
PDE5 GeneProduct ensembl:ENSG00000138735 Also known as PDE5A [uniprot:O76074]
CAMK2A GeneProduct ensembl:ENSG00000070808
GRIN2D GeneProduct ensembl:ENSG00000105464
ADCY8 GeneProduct ensembl:ENSG00000155897
PRKACA GeneProduct ensembl:ENSG00000072062
PDE8A GeneProduct ensembl:ENSG00000073417
ADCY10 GeneProduct ensembl:ENSG00000143199
ADCY6 GeneProduct ensembl:ENSG00000174233
PDE5A GeneProduct ensembl:ENSG00000138735
GRIN1 GeneProduct ensembl:ENSG00000176884
CHRNA7 GeneProduct ensembl:ENSG00000175344
PDE1B GeneProduct ensembl:ENSG00000123360
PDE10A GeneProduct ensembl:ENSG00000112541
PDE11A GeneProduct ensembl:ENSG00000128655
PDE4A GeneProduct ensembl:ENSG00000065989
ADORA2A GeneProduct ensembl:ENSG00000128271
PRKG1 GeneProduct ensembl:ENSG00000185532
ADCY5 GeneProduct ensembl:ENSG00000173175
PDE7A GeneProduct ensembl:ENSG00000205268
GRIA1 GeneProduct ensembl:ENSG00000155511
PDE1A GeneProduct ensembl:ENSG00000115252
DARPP-32 GeneProduct ensembl:ENSG00000131771
DRD2 GeneProduct ensembl:ENSG00000149295
PDE4B GeneProduct ensembl:ENSG00000184588
ADCY7 GeneProduct ensembl:ENSG00000121281
AMPA GeneProduct ensembl:ENSG00000155511
GUCY1A2 GeneProduct ensembl:ENSG00000152402
GUCY1B1 GeneProduct ensembl:ENSG00000061918 Also known as GUCY1B3 [uniprot:Q02153].
GUCY1A1 GeneProduct ensembl:ENSG00000164116 Also known as GUCY1A3 [uniprot:Q02108].
GUCY1B2 GeneProduct ensembl:ENSG00000123201
GUCY1A3 GeneProduct ensembl:ENSG00000164116
GUCY1B3 GeneProduct ensembl:ENSG00000061918

References

  1. Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE). Kitabchi AE, Wilson DB, Sharma RK. Biochem Biophys Res Commun. 1971 Aug 20;44(4):898–904. PubMed Europe PMC Scholia
  2. Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo. Minami N, Suzuki Y, Yamamoto M, Kihira H, Imai E, Wada H, et al. Life Sci. 1997;61(25):PL 383-9. PubMed Europe PMC Scholia
  3. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3’,5’-cyclic nucleotide phosphodiesterase. Loughney K, Hill TR, Florio VA, Uher L, Rosman GJ, Wolda SL, et al. Gene. 1998 Aug 17;216(1):139–47. PubMed Europe PMC Scholia
  4. Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency. Khairallah M, Khairallah RJ, Young ME, Allen BG, Gillis MA, Danialou G, et al. Proc Natl Acad Sci U S A. 2008 May 13;105(19):7028–33. PubMed Europe PMC Scholia
  5. Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor. Kern A, Mavrikaki M, Ullrich C, Albarran-Zeckler R, Brantley AF, Smith RG. Cell. 2015 Nov 19;163(5):1176–90. PubMed Europe PMC Scholia
  6. Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications. Heckman PRA, van Duinen MA, Bollen EPP, Nishi A, Wennogle LP, Blokland A, et al. Int J Neuropsychopharmacol. 2016 Apr 2;19(10):pyw030. PubMed Europe PMC Scholia