Ebola virus infection in host (WP4217)

Homo sapiens

The Ebola virus (EBOV) pathway represents the virus infection on humans, depicted from the left to the right of the picture. The initial targets are macrophages and dendritic cells, but the virus has tropism to infect all kinds of cells, with the exception of lymphocytes. Here we represent all cells in general within one diagram. Ebola attaches to the plasma membrane and after that, a viral glycoprotein induces penetration by endocytosis. This process is made by membrane proteins. During the penetration, its particles travel in compartments where viral glycoproteins are cleaved and fused to the endosomal membrane, which results in the uncoating of viral particles into the cell's cytoplasm. The virus then begins replicating and down-regulating the host's immune response. During the release process, the newly-created viruses are released from host cells, either by causing them to break apart, by waiting for their death, or by budding off through their membrane. Depending on the type of infected cell some trans-infection could happen. This pathway was built using a text-mining approach to obtain interactions between genes related to this process. To our knowledge, it is the first comprehensive pathway depicting the Ebola pathway to date.


Elisson nl , Denise Slenter , Kristina Hanspers , Eric Weitz , Martina Summer-Kutmon , and Egon Willighagen


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Homo sapiens




Disease Ontology

viral infectious disease Ebola hemorrhagic fever


Label Type Compact URI Comment
ITGA2 GeneProduct ensembl:ENSG00000164171
Filamin A GeneProduct ncbigene:2316
CLEC10A GeneProduct ensembl:ENSG00000132514
ASGR1 GeneProduct ensembl:ENSG00000141505
ADAM17 GeneProduct ensembl:ENSG00000151694
ICAM2 GeneProduct ensembl:ENSG00000108622
ICAM3 GeneProduct ensembl:ENSG00000076662
RHOB GeneProduct ensembl:ENSG00000143878
CD209 GeneProduct ensembl:ENSG00000090659
CLEC4M GeneProduct ensembl:ENSG00000104938
HAVCR1 GeneProduct ensembl:ENSG00000113249
GAS6 GeneProduct ensembl:ENSG00000183087
TYRO3 GeneProduct ensembl:ENSG00000092445
ITGA3 GeneProduct ensembl:ENSG00000005884
ITGA4 GeneProduct ensembl:ENSG00000115232
ITGA5 GeneProduct ensembl:ENSG00000161638
ITGA1 GeneProduct ensembl:ENSG00000213949
ITGA6 GeneProduct ensembl:ENSG00000091409
ITGB1 GeneProduct ensembl:ENSG00000150093
ITGB3 GeneProduct ensembl:ENSG00000259207
BST2 GeneProduct ensembl:ENSG00000130303
RAB7A GeneProduct ensembl:ENSG00000075785
RAB5A GeneProduct ensembl:ENSG00000144566
NPC1 GeneProduct ensembl:ENSG00000141458
NPC2 GeneProduct ensembl:ENSG00000119655
CTSB GeneProduct ensembl:ENSG00000164733
CTSL GeneProduct ensembl:ENSG00000135047
AXL GeneProduct ensembl:ENSG00000167601
MERTK GeneProduct ensembl:ENSG00000153208
IKBKE GeneProduct ensembl:ENSG00000263528
IRF7 GeneProduct ensembl:ENSG00000185507
KPNA1 GeneProduct ensembl:ENSG00000114030
CLEC4G GeneProduct ensembl:ENSG00000182566
IQGAP1 GeneProduct ensembl:ENSG00000140575
TBK1 GeneProduct ensembl:ENSG00000183735
C1QBP GeneProduct ensembl:ENSG00000108561
TLR4 GeneProduct ensembl:ENSG00000136869
TIMD4 GeneProduct ensembl:ENSG00000145850
TPCN2 GeneProduct ensembl:ENSG00000162341
TSG101 GeneProduct ensembl:ENSG00000074319
STAT1 GeneProduct ensembl:ENSG00000115415
NEDD4 GeneProduct ensembl:ENSG00000069869
SOCS3 GeneProduct ensembl:ENSG00000184557
PIK3R GeneProduct ensembl:ENSG00000145675
CDC42 GeneProduct ensembl:ENSG00000070831
IRF3 GeneProduct ensembl:ENSG00000126456
CLATHRIN GeneProduct ncbigene:1211
ITGAV GeneProduct ensembl:ENSG00000138448
CLEC6A GeneProduct ensembl:ENSG00000205846
MBL2 GeneProduct ensembl:ENSG00000165471
CAVEOLIN GeneProduct interpro:IPR001612
FOLR1 GeneProduct ensembl:ENSG00000110195
RHOC GeneProduct ensembl:ENSG00000155366
RAC1 GeneProduct ensembl:ENSG00000136238
EGFR GeneProduct ensembl:ENSG00000146648
AKT1 GeneProduct ensembl:ENSG00000142208
MFGE8 GeneProduct ensembl:ENSG00000140545
CD300A GeneProduct ensembl:ENSG00000167851
PRKRA GeneProduct ensembl:ENSG00000180228
DDX58 GeneProduct ensembl:ENSG00000107201
HAVCR2 GeneProduct ensembl:ENSG00000135077
IL4 GeneProduct ensembl:ENSG00000113520
DAB2IP GeneProduct ensembl:ENSG00000136848
TFAP2A GeneProduct ensembl:ENSG00000137203
RAB9A GeneProduct ensembl:ENSG00000123595 PUBMED
EIF2AK2 GeneProduct ensembl:ENSG00000055332
EIF2S1 GeneProduct ensembl:ENSG00000134001
VPS33A GeneProduct ensembl:ENSG00000139719
VPS18 GeneProduct ensembl:ENSG00000104142
VPS39 GeneProduct ensembl:ENSG00000166887
VPS41 GeneProduct ensembl:ENSG00000006715
VPS11 GeneProduct ensembl:ENSG00000160695
VPS16 GeneProduct ensembl:ENSG00000215305
NFKB GeneProduct ensembl:ENSG00000109320
VPS4A GeneProduct ensembl:ENSG00000132612
EPS15 GeneProduct ensembl:ENSG00000085832
RASA2 GeneProduct ensembl:ENSG00000155903
RHOA GeneProduct ensembl:ENSG00000067560
GELSOLIN GeneProduct uniprot:A0A0A0MS51
ACTIN GeneProduct interpro:IPR004000
EP300 GeneProduct ensembl:ENSG00000100393
CREBBP GeneProduct ensembl:ENSG00000005339
CDC44 GeneProduct uniprot:P35251 Annotated according to synonimic name with RFC1 according to Uniprot (although not mentioned for Homo sapiens species).
F-ACTIN GeneProduct ensembl:ENSG00000075624
PAK1 GeneProduct ensembl:ENSG00000149269
TIAM1 GeneProduct ensembl:ENSG00000156299
VAV2 GeneProduct ensembl:ENSG00000160293
IGF1R GeneProduct ensembl:ENSG00000140443
CLTC GeneProduct ensembl:ENSG00000141367
CLTA GeneProduct ensembl:ENSG00000122705
CLTB GeneProduct ensembl:ENSG00000175416
CLTCL1 GeneProduct ensembl:ENSG00000070371
CAV1 GeneProduct ensembl:ENSG00000105974
CAV2 GeneProduct ensembl:ENSG00000105971
CAV3 GeneProduct ensembl:ENSG00000182533
PIK3R1 GeneProduct ensembl:ENSG00000145675
PIK3CA GeneProduct ensembl:ENSG00000121879
PIK3CB GeneProduct ensembl:ENSG00000051382
PIK3CD GeneProduct ensembl:ENSG00000171608
PIK3R3 GeneProduct ensembl:ENSG00000117461
PIK3R2 GeneProduct ensembl:ENSG00000105647
PP1 GeneProduct eccode:
LC8 GeneProduct ncbiprotein:8655
TOP1 GeneProduct ensembl:ENSG00000198900
FLNA GeneProduct ensembl:ENSG00000196924
FLNB GeneProduct ensembl:ENSG00000136068
FLNC GeneProduct ensembl:ENSG00000128591
GSN GeneProduct ensembl:ENSG00000148180
SCIN GeneProduct ensembl:ENSG00000006747
MAPK1 GeneProduct ensembl:ENSG00000100030
MAPK3 GeneProduct hgnc.symbol:MAPK3
NFKB1 GeneProduct ensembl:ENSG00000109320
NFKB2 GeneProduct ensembl:ENSG00000077150
REL GeneProduct ncbigene:5966
RELA GeneProduct ensembl:ENSG00000173039
ACTN1 GeneProduct ensembl:ENSG00000072110
ACTN4 GeneProduct ensembl:ENSG00000130402
ACTB GeneProduct ensembl:ENSG00000075624
ACTG1 GeneProduct ensembl:ENSG00000184009
HLA-A GeneProduct ensembl:ENSG00000206503
HLA-B GeneProduct ensembl:ENSG00000234745
HLA-C GeneProduct ensembl:ENSG00000204525
HLA-DMA GeneProduct ensembl:ENSG00000204257
HLA-DMB GeneProduct ensembl:ENSG00000242574
HLA-DOA GeneProduct ensembl:ENSG00000204252
HLA-DOB GeneProduct ensembl:ENSG00000241106
HLA-DPA1 GeneProduct ensembl:ENSG00000231389
HLA-E GeneProduct ensembl:ENSG00000204592
HLA-F GeneProduct ensembl:ENSG00000204642
HLA-G GeneProduct ensembl:ENSG00000204632
HLA-DPB1 GeneProduct ensembl:ENSG00000223865
HLA-DQA1 GeneProduct ensembl:ENSG00000196735
HLA-DQA2 GeneProduct ensembl:ENSG00000237541
HLA-DQB1 GeneProduct ensembl:ENSG00000179344
HLA-DQB2 GeneProduct ensembl:ENSG00000232629
HLA-DRA GeneProduct ensembl:ENSG00000204287
HLA-DRB1 GeneProduct ensembl:ENSG00000196126
HLA-DRB3 GeneProduct ncbigene:3125
HLA-DRB4 GeneProduct ncbigene:3126
HLA-DRB5 GeneProduct ensembl:ENSG00000198502
RELB GeneProduct ensembl:ENSG00000104856
Filamin B GeneProduct ncbigene:2317
Filamin C GeneProduct ncbigene:2318


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