Immune response to tuberculosis (WP4197)

Homo sapiens

This pathway is published in "The human immune response to tuberculosis and its treatment: a view from the blood" (PMID: 25703554). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP4197 CPTAC Assay Portal].

Authors

Andra Waagmeester , Egon Willighagen , Kristina Hanspers , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

tuberculosis

Participants

Label Type Compact URI Comment
IRF9 GeneProduct ensembl:ENSG00000213928
PSMB8 GeneProduct ensembl:ENSG00000204264
OAS1 GeneProduct ensembl:ENSG00000089127
MX1 GeneProduct ensembl:ENSG00000157601
IRF1 GeneProduct ensembl:ENSG00000125347
SOCS1 GeneProduct ensembl:ENSG00000185338
STAT1 GeneProduct ensembl:ENSG00000115415
PIAS1 GeneProduct ensembl:ENSG00000033800
STAT1 GeneProduct ensembl:ENSG00000115415
IFITM1 GeneProduct ensembl:ENSG00000185885
IRF9 GeneProduct ensembl:ENSG00000213928
PSMB8 GeneProduct ensembl:ENSG00000204264
IFNGR1 GeneProduct ensembl:ENSG00000027697
IRF9 GeneProduct ensembl:ENSG00000213928
PTPN2 GeneProduct ensembl:ENSG00000175354
TAP1 GeneProduct ensembl:ENSG00000168394
IFI35 GeneProduct ensembl:ENSG00000068079
IFIT1 GeneProduct ensembl:ENSG00000185745
IFITM1 GeneProduct ensembl:ENSG00000185885
IFI35 GeneProduct ensembl:ENSG00000068079
TYK2 GeneProduct ensembl:ENSG00000105397
JAK1 GeneProduct ensembl:ENSG00000162434
IFIT3 GeneProduct ensembl:ENSG00000119917
STAT1 GeneProduct ensembl:ENSG00000115415
STAT1 GeneProduct ensembl:ENSG00000115415
STAT1 GeneProduct ensembl:ENSG00000115415
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
JAK2 GeneProduct ensembl:ENSG00000096968
PTPN2 GeneProduct ensembl:ENSG00000175354
JAK1 GeneProduct ensembl:ENSG00000162434
JAK2 GeneProduct ensembl:ENSG00000096968
JAK1 GeneProduct ensembl:ENSG00000162434
STAT1 GeneProduct ensembl:ENSG00000115415
STAT2 GeneProduct ensembl:ENSG00000170581
PTPN2 GeneProduct ensembl:ENSG00000175354
IFNGR2 GeneProduct ensembl:ENSG00000159128
IFNGR1 GeneProduct ensembl:ENSG00000027697
IFNGR2 GeneProduct ensembl:ENSG00000159128
IFNAR1 GeneProduct ensembl:ENSG00000142166
IFNAR2 GeneProduct ensembl:ENSG00000159110

References

  1. An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Berry MPR, Graham CM, McNab FW, Xu Z, Bloch SAA, Oni T, et al. Nature. 2010 Aug 19;466(7309):973–7. PubMed Europe PMC Scholia
  2. Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response. Cliff JM, Lee JS, Constantinou N, Cho JE, Clark TG, Ronacher K, et al. J Infect Dis. 2013 Jan 1;207(1):18–29. PubMed Europe PMC Scholia
  3. Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. Bloom CI, Graham CM, Berry MPR, Rozakeas F, Redford PS, Wang Y, et al. PLoS One. 2013 Aug 5;8(8):e70630. PubMed Europe PMC Scholia
  4. The human immune response to tuberculosis and its treatment: a view from the blood. Cliff JM, Kaufmann SHE, McShane H, van Helden P, O’Garra A. Immunol Rev. 2015 Mar;264(1):88–102. PubMed Europe PMC Scholia