White fat cell differentiation (WP4149)
Homo sapiens
The transcription factors involved in white fat cell differentiation are shown, specifically their pattern of activity from the preadipocyte to the adipocyte (fat cells) stage. Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.
Authors
Martina Summer-KutmonActivity
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Cited In
- Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
- Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease (2022).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
signaling pathwayCell Type Ontology
white fat cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| cAMP | Metabolite | chebi:17489 | |
| Glucocorticoids | Metabolite | chebi:24261 | |
| WNT10B | GeneProduct | ensembl:ENSG00000169884 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22410 |
| EBF1 | GeneProduct | ensembl:ENSG00000164330 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13591 |
| SREBF1 | GeneProduct | ensembl:ENSG00000072310 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20787 |
| CEBPA | GeneProduct | ensembl:ENSG00000245848 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12606 |
| CEBPB | GeneProduct | ensembl:ENSG00000172216 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12608 |
| MECOM | GeneProduct | ensembl:ENSG00000085276 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14013 |
| RORA | GeneProduct | ensembl:ENSG00000069667 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19883 |
| DDIT3 | GeneProduct | ensembl:ENSG00000175197 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13198 |
| CREB1 | GeneProduct | ensembl:ENSG00000118260 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912 |
| IRF3 | GeneProduct | ensembl:ENSG00000126456 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:54131 |
| STAT5B | GeneProduct | ensembl:ENSG00000173757 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20851 |
| KLF15 | GeneProduct | ensembl:ENSG00000163884 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66277 |
| KLF5 | GeneProduct | ensembl:ENSG00000102554 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12224 |
| GATA2 | GeneProduct | ensembl:ENSG00000179348 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14461 |
| TCF7L1 | GeneProduct | ensembl:ENSG00000152284 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21415 |
| ZNF423 | GeneProduct | ensembl:ENSG00000102935 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94187 |
| EGR2 | GeneProduct | ensembl:ENSG00000122877 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13654 |
| GATA3 | GeneProduct | ensembl:ENSG00000107485 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14462 |
| NR2F2 | GeneProduct | ensembl:ENSG00000185551 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11819 |
| PPARG | GeneProduct | ensembl:ENSG00000132170 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016 |
| NR1H3 | GeneProduct | ensembl:ENSG00000025434 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259 |
| CEBPD | GeneProduct | ensembl:ENSG00000221869 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12609 |
| CTNNA1 | GeneProduct | ensembl:ENSG00000044115 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12385 |
| KLF4 | GeneProduct | ensembl:ENSG00000136826 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16600 |
| RARA | GeneProduct | ensembl:ENSG00000131759 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19401 |
| FOXO1 | GeneProduct | ensembl:ENSG00000150907 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56458 |
| STAT5A | GeneProduct | ensembl:ENSG00000126561 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20850 |
| TLE3 | GeneProduct | ensembl:ENSG00000140332 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21887 |
| INS | GeneProduct | ensembl:ENSG00000254647 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333 |
| NR3C1 | GeneProduct | ensembl:ENSG00000113580 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14815 |
| IRF4 | GeneProduct | ensembl:ENSG00000137265 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16364 |
| KLF2 | GeneProduct | ensembl:ENSG00000127528 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16598 |
References
- Molecular regulation of adipogenesis. Rosen ED, Spiegelman BM. Annu Rev Cell Dev Biol. 2000;16:145–71. PubMed Europe PMC Scholia
- Adipocyte differentiation from the inside out. Rosen ED, MacDougald OA. Nat Rev Mol Cell Biol. 2006 Dec;7(12):885–96. PubMed Europe PMC Scholia
- TLE3 is a dual-function transcriptional coregulator of adipogenesis. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, et al. Cell Metab. 2011 Apr 6;13(4):413–27. PubMed Europe PMC Scholia
- Transcriptional networks and chromatin remodeling controlling adipogenesis. Siersbæk R, Nielsen R, Mandrup S. Trends Endocrinol Metab. 2012 Feb;23(2):56–64. PubMed Europe PMC Scholia
- Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network. Gubelmann C, Schwalie PC, Raghav SK, Röder E, Delessa T, Kiehlmann E, et al. Elife. 2014 Aug 27;3:e03346. PubMed Europe PMC Scholia