G1 to S cell cycle control (WP413)

Mus musculus

In the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding CKIs mediated by the p53 protein, whereas the p53-independent mechanisms inhibit CDKs through the inhibitory T14Y15 phosphorylation of Cdk2. Failure of DNA damage checkpoints in G1 leads to mutagenic replication of damaged templates and other replication defects. Source: Reactome http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&FOCUS_SPECIES=Homo%20sapiens&ID=69615&


Alexander C. Zambon , Nathan Salomonis , Kristina Hanspers , Christine Chichester , and Martina Summer-Kutmon


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Mus musculus



Pathway Ontology

G1/S DNA damage checkpoint pathway


Label Type Compact URI Comment
Cdk4 GeneProduct ncbigene:12567
Cdk6 GeneProduct ncbigene:12571
Ccnd1 GeneProduct ncbigene:12443
Ccnd2 GeneProduct ncbigene:12444
Ccnd3 GeneProduct ncbigene:12445
Cdkn1a GeneProduct ncbigene:12575
Cdkn1b GeneProduct ncbigene:12576
Cdk7 GeneProduct ncbigene:12572
Ccnh GeneProduct ncbigene:66671
E2f1 GeneProduct ncbigene:13555
E2f2 GeneProduct ncbigene:242705
E2f3 GeneProduct ncbigene:13557
Rbl1 GeneProduct ncbigene:19650
Rb1 GeneProduct ncbigene:19645
E2f4 GeneProduct ncbigene:104394
E2f5 GeneProduct ncbigene:13559
E2f6 GeneProduct ncbigene:50496
Tfdp1 GeneProduct ncbigene:21781
Tfdp2 GeneProduct ncbigene:211586
Cdk2 GeneProduct ncbigene:12566
Ccne1 GeneProduct ncbigene:12447
Ccne2 GeneProduct ncbigene:12448
Pole2 GeneProduct ncbigene:18974
Pole GeneProduct ncbigene:18973
Cdc25a GeneProduct ncbigene:12530
Wee1 GeneProduct ncbigene:22390
Pkmyt1 GeneProduct ncbigene:268930
Cdc2a GeneProduct ncbigene:12534
Cdk4 GeneProduct ncbigene:12567
Cdk6 GeneProduct ncbigene:12571
Cdk7 GeneProduct ncbigene:12572
Cdc45l GeneProduct ncbigene:12544
Rpa2 GeneProduct ncbigene:19891
Rpa3 GeneProduct ncbigene:68240
Rpa1 GeneProduct ncbigene:68275
Mcm2 GeneProduct ncbigene:17216
Mcm3 GeneProduct ncbigene:17215
Mcm4 GeneProduct ncbigene:17217
Mcm5 GeneProduct ncbigene:17218
Mcm6 GeneProduct ncbigene:17219
Mcm7 GeneProduct ncbigene:17220
Orc1l GeneProduct ncbigene:18392
Orc2l GeneProduct ncbigene:18393
Orc3l GeneProduct ncbigene:50793
Orc4l GeneProduct ncbigene:26428
Orc5l GeneProduct ncbigene:26429
Orc6l GeneProduct ncbigene:56452
Prim1 GeneProduct ncbigene:19075
Prim2 GeneProduct ncbigene:19076
Pola2 GeneProduct ncbigene:18969
Pcna GeneProduct ncbigene:18538
Trp53 GeneProduct ncbigene:22059
Gadd45a GeneProduct ncbigene:13197
Mdm2 GeneProduct ncbigene:17246
Cdkn2c GeneProduct ncbigene:12580
Cdkn2b GeneProduct ncbigene:12579
Cdkn2d GeneProduct ncbigene:12581
Cdkn2a GeneProduct ncbigene:12578
Cdc2a GeneProduct ncbigene:12534
Ccna1 GeneProduct ncbigene:12427
Ccnb1-rs1 GeneProduct ncbigene:12429
Atm GeneProduct ncbigene:11920
Cdkn1c GeneProduct ncbigene:12577
Ccng2 GeneProduct ncbigene:12452
Myc GeneProduct ncbigene:17869
Mnat1 GeneProduct ncbigene:17420


  1. GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA. J Invest Dermatol. 2002 Jul;119(1):22–6. PubMed Europe PMC Scholia