Nucleotide metabolism (WP404)
Homo sapiens
The pathway outlined above focuses on purine metabolism and in particular that of guanine metabolism. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Nick Fidelman , Txr24 , Thomas Kelder , Mjh , Kristina Hanspers , Eric Weitz , and Egon WillighagenActivity
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Organisms
Homo sapiensCommunities
CPTACAnnotations
Pathway Ontology
purine metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| DNA | Metabolite | chebi:16991 | |
| GMP | Metabolite | cas:85-32-5 | |
| AMP | Metabolite | hmdb:HMDB0003540 | |
| Spermidine | Metabolite | cas:124-20-9 | |
| Uric Acid | Metabolite | cas:69-93-2 | |
| Adenine | Metabolite | cas:73-24-5 | |
| Putrescine | Metabolite | cas:110-60-1 | |
| Xanthine monophosphate | Metabolite | cas:69-89-6 | |
| Hypoxanthine | Metabolite | cas:68-94-0 | |
| Guanine | Metabolite | cas:73-40-5 | |
| PRPP | Metabolite | cas:97-55-2 | |
| AICAR | Metabolite | cas:3031-94-5 | |
| Spermine | Metabolite | cas:71-44-3 | |
| IMP | Metabolite | chebi:17202 | |
| Adenylosuccinate | Metabolite | chebi:15919 | |
| Ornithine | Metabolite | cas:70-26-8 | |
| Ribose | Metabolite | cas:50-69-1 | |
| SAICAR | Metabolite | cas:3031-95-6 | |
| PRPS2 | GeneProduct | ncbigene:5634 | |
| POLD1 | GeneProduct | ncbigene:5424 | |
| RRM1 | GeneProduct | ncbigene:6240 | |
| IMPDH1 | GeneProduct | ncbigene:3614 | |
| OAZ1 | GeneProduct | ncbigene:4946 | |
| SAT | GeneProduct | ncbigene:6303 | |
| NME2 | GeneProduct | ncbigene:4831 | |
| MTHFD2 | GeneProduct | ncbigene:10797 | |
| RRM2 | GeneProduct | ncbigene:6241 | |
| PRPS1 | GeneProduct | ncbigene:5631 | Mouse: AA110812 |
| POLB | GeneProduct | ncbigene:5423 | |
| RRM2B | GeneProduct | ncbigene:50484 | |
| HPRT1 | GeneProduct | ncbigene:3251 | |
| ADSL | GeneProduct | ncbigene:158 | |
| POLG | GeneProduct | ncbigene:5428 | |
| POLA | GeneProduct | ncbigene:5422 | |
| DHFR | GeneProduct | ncbigene:1719 | |
| SRM | GeneProduct | ncbigene:6723 | |
| ADSS | GeneProduct | ncbigene:159 |