Model of Fgf and Wnt crosstalk in tailbud (WP4021)

Danio rerio

A simple model of the Fgf and Wnt gene network in the zebrafish tailbud. Fgf signaling inhibits transcription of the Wnt inhibitors dkk1 and notum1a. PI3k signaling activates the Wnt pathway by phosphorylating (inactivating) Gsk3β. Phosphorylation of Gsk3β also leads to an increase in active Erk levels, suggesting Wnt signaling promotes Mapk activity. Fgf and Wnt have opposing effects on transcription of co-regulated genes, which include Fgf (spred3) and Wnt (dkk1, notum1a) inhibitors. (From Stulberg et al)


Kristina Hanspers


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Danio rerio



Pathway Ontology

fibroblast growth factor signaling pathway Wnt signaling pathway


Label Type Compact URI Comment
pik3cb GeneProduct zfin:ZDB-GENE-030131-1904
gsk3b GeneProduct zfin:ZDB-GENE-990714-4
spt GeneProduct zfin:ZDB-GENE-990615-5
notum1a GeneProduct zfin:ZDB-GENE-120807-2
dkk1a GeneProduct zfin:ZDB-GENE-090313-406
erk2 GeneProduct zfin:ZDB-GENE-030722-2
fgf8a GeneProduct zfin:ZDB-GENE-990415-72
wnt11 GeneProduct zfin:ZDB-GENE-990603-12
tbx6 GeneProduct zfin:ZDB-GENE-020416-5
dkk1b GeneProduct zfin:ZDB-GENE-990708-5
erk1 GeneProduct zfin:ZDB-GENE-040121-1
ntl GeneProduct zfin:ZDB-GENE-980526-437
spred3 GeneProduct zfin:ZDB-GENE-061207-31
pik3cd GeneProduct zfin:ZDB-GENE-040426-1128
pik3cg GeneProduct zfin:ZDB-GENE-040426-2532
pik3ca GeneProduct zfin:ZDB-GENE-130409-1
fgf3 GeneProduct zfin:ZDB-GENE-980526-178
fgf10a GeneProduct zfin:ZDB-GENE-030715-1
fgf4 GeneProduct zfin:ZDB-GENE-001006-1
fgf17 GeneProduct zfin:ZDB-GENE-040621-1
fgf19 GeneProduct zfin:ZDB-GENE-030729-32
fgf24 GeneProduct zfin:ZDB-GENE-030708-1
fgf10b GeneProduct zfin:ZDB-GENE-060828-1
fgf16 GeneProduct zfin:ZDB-GENE-060427-3
wnt5b GeneProduct zfin:ZDB-GENE-980526-87
wnt3a GeneProduct zfin:ZDB-GENE-001106-1
wnt8a GeneProduct zfin:ZDB-GENE-980526-332
wnt3 GeneProduct zfin:ZDB-GENE-081003-1
wnt7ba GeneProduct zfin:ZDB-GENE-041210-178


  1. Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Stulberg MJ, Lin A, Zhao H, Holley SA. Dev Biol. 2012 Sep 15;369(2):298–307. PubMed Europe PMC Scholia