Ethanol effects on histone modifications (WP3996)

Homo sapiens

Ethanol effects on histone modifications which contribute to the development of fetal alcohol syndrome. Pathway based on Chater-Diehl et al. 2017 ( Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Friederike Ehrhart , Marvin Martens , Kristina Hanspers , and Egon Willighagen


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Homo sapiens



Disease Ontology

fetal alcohol spectrum disorder

Pathway Ontology

altered histone modification pathway


Label Type Compact URI Comment
Homocysteine Metabolite hmdb:HMDB0000742
L-Serine Metabolite hmdb:HMDB0000187
dTMP Metabolite hmdb:HMDB0001227
dUMP Metabolite hmdb:HMDB0001409
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
Tetrahydrofolate Metabolite chebi:67016
Folic acid Metabolite hmdb:HMDB0000121
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
Ethanol Metabolite hmdb:HMDB0000108
Nucleic acids Metabolite chebi:33696
L-Methionine Metabolite hmdb:HMDB0000696
Pyrimidines Metabolite chebi:39447
5,10-MTHF Metabolite hmdb:HMDB0001533
Glycine Metabolite hmdb:HMDB0000123
Dihydrofolate Metabolite chebi:15633
5-MTHF Metabolite hmdb:HMDB0001396
Acetaldehyde Metabolite hmdb:HMDB0000990
Acetate Metabolite chebi:30089
Acetyl-CoA Metabolite hmdb:HMDB0001206
Coenzyme A Metabolite hmdb:HMDB0001423
Reactive oxygen species Metabolite chebi:26523
Reactive oxygen species Metabolite chebi:26523
Reactive oxygen species Metabolite chebi:26523
ELP3 GeneProduct ensembl:ENSG00000134014
AHCY GeneProduct ensembl:ENSG00000101444
TYMS GeneProduct ensembl:ENSG00000176890
DHFR GeneProduct ensembl:ENSG00000228716
MTHFR GeneProduct ensembl:ENSG00000177000
EHMT2 GeneProduct ensembl:ENSG00000204371 G9a
ATF2 GeneProduct ensembl:ENSG00000115966
HDAC2 GeneProduct ensembl:ENSG00000196591
KAT2B GeneProduct ensembl:ENSG00000114166 also known as PCAF
MTR GeneProduct ensembl:ENSG00000116984
MAT1A GeneProduct ensembl:ENSG00000151224
HDAC1 GeneProduct ensembl:ENSG00000116478
HAT1 GeneProduct ensembl:ENSG00000128708
SLC19A1 GeneProduct ensembl:ENSG00000173638 Formerly known as RFC1
ACSS2 GeneProduct ensembl:ENSG00000131069
ADH1B GeneProduct ensembl:ENSG00000196616
CYP2E1 GeneProduct ensembl:ENSG00000130649
ADH1A GeneProduct ensembl:ENSG00000187758
ALDH1A1 GeneProduct ensembl:ENSG00000165092
ALDH2 GeneProduct ensembl:ENSG00000111275
ADH1C GeneProduct ensembl:ENSG00000248144
ALDH1A2 GeneProduct ensembl:ENSG00000128918
ALDH1A3 GeneProduct ensembl:ENSG00000184254
HDAC3 GeneProduct ensembl:ENSG00000171720
HDAC4 GeneProduct ensembl:ENSG00000068024
HDAC5 GeneProduct ensembl:ENSG00000108840
HDAC6 GeneProduct ensembl:ENSG00000094631
HDAC7 GeneProduct ensembl:ENSG00000061273
HDAC8 GeneProduct ensembl:ENSG00000147099
HDAC9 GeneProduct ensembl:ENSG00000048052
HDAC10 GeneProduct ensembl:ENSG00000100429


  1. Histone acetyltransferase complexes: one size doesn’t fit all. Lee KK, Workman JL. Nat Rev Mol Cell Biol. 2007 Apr;8(4):284–95. PubMed Europe PMC Scholia
  2. Changes to histone modifications following prenatal alcohol exposure: An emerging picture. Chater-Diehl EJ, Laufer BI, Singh SM. Alcohol. 2017 May;60:41–52. PubMed Europe PMC Scholia