Protein alkylation leading to liver fibrosis (WP3980)

Homo sapiens

Protein alkylation leading to liver fibrosis This pathway is based on descriptive text of the adverse outcome pathway (AOP) on


Marvin Martens and Egon Willighagen


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Homo sapiens


Adverse Outcome Pathways


Pathway Ontology

liver disease pathway

Disease Ontology

liver disease


Label Type Compact URI Comment
thioacetamide Metabolite wikidata:Q416253
Dimethylnitrosamine Metabolite chebi:35807
allyl alcohol Metabolite chebi:16605
retinol Metabolite chebi:50211
CCl4 Metabolite chebi:27385


  1. Adverse outcome pathway development from protein alkylation to liver fibrosis. Horvat T, Landesmann B, Lostia A, Vinken M, Munn S, Whelan M. Arch Toxicol. 2017 Apr;91(4):1523–43. PubMed Europe PMC Scholia