Mevalonate pathway (WP3963)

Homo sapiens

The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea, and some bacteria. The pathway produces two five-carbon building blocks called isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are used to make isoprenoids, a diverse class of over 30,000 biomolecules such as cholesterol, vitamin K, coenzyme Q10, and all steroid hormones. (Wikipedia)


Kristina Hanspers , Jacob Windsor , Martina Summer-Kutmon , Egon Willighagen , and Alex Pico


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Homo sapiens



Pathway Ontology

isoprenoid metabolic pathway


Label Type Compact URI Comment
(R)-5-diphosphomevalonate Metabolite chebi:15899
Dimethylallyl diphosphate Metabolite chebi:16057
Acetyl-CoA Metabolite chebi:15351
Dolichol Metabolite chebi:88766
Ubiquinone Metabolite chebi:16389
Geranyl diphosphate Metabolite chebi:17211
Acetoacetyl-CoA Metabolite chebi:15345
(R)-5-phosphomevalonate Metabolite chebi:17436
HMG-CoA Metabolite chebi:15467
mevalonate Metabolite wikidata:Q27109878
Cholesterol Metabolite hmdb:HMDB0000067
ACAT2 GeneProduct ensembl:ENSG00000120437
PMVK GeneProduct ensembl:ENSG00000163344
MVD GeneProduct ensembl:ENSG00000167508
HMGCS1 GeneProduct ensembl:ENSG00000112972
MVK GeneProduct ensembl:ENSG00000110921
FDPS GeneProduct ensembl:ENSG00000160752
HMGCR GeneProduct ensembl:ENSG00000113161


  1. The interplay between cell signalling and the mevalonate pathway in cancer. Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ. Nat Rev Cancer. 2016 Nov;16(11):718–31. PubMed Europe PMC Scholia