mRNA, protein, and metabolite inducation pathway by cyclosporin A (WP3953)
Homo sapiens
Exposure to cyclosporin A triggers a cascade of changes in expression and abundance of various mRNAs, proteins, and metabolites, which can be measured experimentally.
Authors
Egon Willighagen , Elisa Cirillo , Kristina Hanspers , Friederike Ehrhart , and Denise SlenterActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
xenobiotic metabolic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Pi | Metabolite | chebi:18367 | Assuming this is Phosphate ion |
| L-leucine | Metabolite | chebi:15603 | |
| ROS | Metabolite | wikidata:Q424361 | |
| cysteine | Metabolite | chebi:15356 | |
| L-Isoleucine | Metabolite | chebi:17191 | |
| L-tyrosine | Metabolite | chebi:17895 | |
| L-Valine | Metabolite | chebi:16414 | |
| L-tryptophan | Metabolite | chebi:16828 | |
| L-threonine | Metabolite | chebi:16857 | |
| L-alanine | Metabolite | chebi:16977 | |
| L-glutamine | Metabolite | chebi:18050 | |
| L-asparagine | Metabolite | chebi:17196 | |
| ADP | Metabolite | hmdb:HMDB0001341 | |
| L-cysteine | Metabolite | hmdb:HMDB0000574 | |
| SLC3A2 | GeneProduct | ensembl:ENSG00000168003 | |
| SLC7A5 | GeneProduct | ensembl:ENSG00000103257 | |
| SLC1A5 | GeneProduct | ensembl:ENSG00000105281 | |
| SLC3A2 | GeneProduct | ensembl:ENSG00000168003 | |
| SLC7A5 | GeneProduct | ensembl:ENSG00000103257 | |
| SLC1A5 | GeneProduct | ensembl:ENSG00000105281 | |
| ATF4 | GeneProduct | ensembl:ENSG00000128272 | |
| SLC7A11 | GeneProduct | ensembl:ENSG00000151012 | |
| SLC3A2 | GeneProduct | ensembl:ENSG00000168003 | |
| SLC7A11 | GeneProduct | ensembl:ENSG00000151012 | |
| Nrf2 | Protein | uniprot:Q16236 | |
| ATF4 | Protein | uniprot:Q96AQ3 | |
| KEAP1 | Protein | ensembl:ENSG00000079999 | |
| KEAP1 | Protein | ensembl:ENSG00000079999 |
References
- Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress. Wilmes A, Limonciel A, Aschauer L, Moenks K, Bielow C, Leonard MO, et al. J Proteomics. 2013 Feb 21;79:180–94. PubMed Europe PMC Scholia