PPAR signaling (WP3942)

Homo sapiens

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3942 CPTAC Assay Portal]

Authors

Kristina Hanspers , Denise Slenter , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

peroxisome proliferator-activated receptor signaling pathway signaling pathway peroxisome proliferator-activated receptor signaling pathway

Cell Type Ontology

cell of skeletal muscle white fat cell

Participants

Label Type Compact URI Comment
unsaturated fatty acids Metabolite chebi:27208
saturated fatty acids Metabolite chebi:26607
eicosanoid Metabolite chebi:23899
ciprofibrate Metabolite chebi:50867
NSAIDs Metabolite chebi:35475
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
Thiazolidine derivative Metabolite chebi:35622
ACAA1 GeneProduct ensembl:ENSG00000060971 Original kegg element: gene;21;mmu:113868 mmu:235674
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235674
PPARD GeneProduct ensembl:ENSG00000112033 Original kegg element: gene;16;mmu:19015
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19015
PPARG GeneProduct ensembl:ENSG00000132170 Original kegg element: gene;18;mmu:19016
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19016
PCK2 GeneProduct ensembl:ENSG00000100889 Original kegg element: gene;9;mmu:18534 mmu:74551
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74551
CYP4A11 GeneProduct ensembl:ENSG00000187048 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:666168
CYP8B1 GeneProduct ensembl:ENSG00000180432 Original kegg element: gene;58;mmu:13124
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13124
UCP1 GeneProduct ensembl:ENSG00000109424 Original kegg element: gene;66;mmu:22227
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22227
SLC27A1 GeneProduct ensembl:ENSG00000130304 Original kegg element: gene;36;mmu:26457 mmu:26569
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457
HMGCS2 GeneProduct ensembl:ENSG00000134240 Original kegg element: gene;37;mmu:15360
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360
CYP4A11 GeneProduct ensembl:ENSG00000187048 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13117
RXRB GeneProduct ensembl:ENSG00000204231 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182
AQP7 GeneProduct ensembl:ENSG00000165269 Original kegg element: gene;7;mmu:11832
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11832
SCD GeneProduct ensembl:ENSG00000099194 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20250
ACOX1 GeneProduct ensembl:ENSG00000161533 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11430
CYP4A11 GeneProduct ensembl:ENSG00000187048 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13118
SCD GeneProduct ensembl:ENSG00000099194 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:30049
SCD GeneProduct ensembl:ENSG00000099194 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:329065
NR1H3 GeneProduct ensembl:ENSG00000025434 Original kegg element: gene;59;mmu:22259
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22259
RXRA GeneProduct ensembl:ENSG00000186350 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181
ACSBG2 GeneProduct ensembl:ENSG00000130377 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:328845
FABP1 GeneProduct ensembl:ENSG00000163586 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080
CYP4A11 GeneProduct ensembl:ENSG00000187048 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13119
RXRG GeneProduct ensembl:ENSG00000143171 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183
RXRB GeneProduct ensembl:ENSG00000204231 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182
ACSL6 GeneProduct ensembl:ENSG00000164398 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216739
ANGPTL4 GeneProduct ensembl:ENSG00000167772 Original kegg element: gene;41;mmu:57875
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:57875
CYP27A1 GeneProduct ensembl:ENSG00000135929 Original kegg element: gene;60;mmu:104086
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086
ACSL3 GeneProduct ensembl:ENSG00000123983 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74205
FABP7 GeneProduct ensembl:ENSG00000164434 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12140
ACADM GeneProduct ensembl:ENSG00000117054 Original kegg element: gene;22;mmu:11364
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11364
CPT1B GeneProduct ensembl:ENSG00000205560 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12895
CPT1C GeneProduct ensembl:ENSG00000169169 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78070
RXRA GeneProduct ensembl:ENSG00000186350 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181
CYP4A11 GeneProduct ensembl:ENSG00000187048 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:277753
FABP3 GeneProduct ensembl:ENSG00000121769 Original kegg element: gene;32;mmu:14077
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077
CYP4A11 GeneProduct ensembl:ENSG00000187048 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:100040843
FABP2 GeneProduct ensembl:ENSG00000145384 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14079
ACSL4 GeneProduct ensembl:ENSG00000068366 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50790
DBI GeneProduct ensembl:ENSG00000155368 Original kegg element: gene;63;mmu:13167
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13167
SLC27A2 GeneProduct ensembl:ENSG00000140284 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26458
SLC27A4 GeneProduct ensembl:ENSG00000167114 Original kegg element: gene;36;mmu:26457 mmu:26569
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569
APOA2 GeneProduct ensembl:ENSG00000158874 Original kegg element: gene;46;mmu:11807
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11807
CD36 GeneProduct ensembl:ENSG00000135218 Original kegg element: gene;31;mmu:12491
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491
SLC27A1 GeneProduct ensembl:ENSG00000130304 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26457
FABP1 GeneProduct ensembl:ENSG00000163586 Original kegg element: gene;44;mmu:14080
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14080
ME1 GeneProduct ensembl:ENSG00000065833 Original kegg element: gene;65;mmu:17436
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17436
ADIPOQ GeneProduct ensembl:ENSG00000181092 Original kegg element: gene;53;mmu:11450
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11450
APOC3 GeneProduct ensembl:ENSG00000110245 Original kegg element: gene;57;mmu:11814
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11814
ACSL5 GeneProduct ensembl:ENSG00000197142 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:433256
FABP4 GeneProduct ensembl:ENSG00000170323 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770
PPARA GeneProduct ensembl:ENSG00000186951 Original kegg element: gene;14;mmu:19013
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:19013
FADS2 GeneProduct ensembl:ENSG00000134824 Original kegg element: gene;56;mmu:56473
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56473
RXRG GeneProduct ensembl:ENSG00000143171 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183
CYP7A1 GeneProduct ensembl:ENSG00000167910 Original kegg element: gene;33;mmu:13122
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13122
PLTP GeneProduct ensembl:ENSG00000100979 Original kegg element: gene;47;mmu:18830
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18830
GK3P GeneProduct ensembl:ENSG00000229894 Original kegg element: gene;8;mmu:14626 mmu:14933
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14933
PLIN1 GeneProduct ensembl:ENSG00000166819 Original kegg element: gene;10;mmu:103968
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:103968
SLC27A5 GeneProduct ensembl:ENSG00000083807 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26459
ACOX3 GeneProduct ensembl:ENSG00000087008 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:80911
APOA5 GeneProduct ensembl:ENSG00000110243 Original kegg element: gene;64;mmu:66113
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:66113
ACOX2 GeneProduct ensembl:ENSG00000168306 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:93732
PCK1 GeneProduct ensembl:ENSG00000124253 Original kegg element: gene;9;mmu:18534 mmu:74551
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18534
CPT2 GeneProduct ensembl:ENSG00000157184 Original kegg element: gene;26;mmu:12896
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12896
ACSL1 GeneProduct ensembl:ENSG00000151726 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14081
FABP6 GeneProduct ensembl:ENSG00000170231 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16204
RXRB GeneProduct ensembl:ENSG00000204231 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20182
MMP1 GeneProduct ensembl:ENSG00000196611 Original kegg element: gene;39;mmu:83995 mmu:83996
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83996
OLR1 GeneProduct ensembl:ENSG00000173391 Original kegg element: gene;29;mmu:108078
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108078
SLC27A4 GeneProduct ensembl:ENSG00000167114 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26569
CYP4A11 GeneProduct ensembl:ENSG00000187048 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:230639
CD36 GeneProduct ensembl:ENSG00000135218 Original kegg element: gene;11;mmu:12491
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12491
MMP1 GeneProduct ensembl:ENSG00000196611 Original kegg element: gene;39;mmu:83995 mmu:83996
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:83995
SLC27A6 GeneProduct ensembl:ENSG00000113396 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:225579
CYP4A11 GeneProduct ensembl:ENSG00000187048 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:435802
ACSBG1 GeneProduct ensembl:ENSG00000103740 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:94180
SCP2 GeneProduct ensembl:ENSG00000116171 Original kegg element: gene;20;mmu:20280
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20280
SCD GeneProduct ensembl:ENSG00000099194 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20249
LPL GeneProduct ensembl:ENSG00000175445 Original kegg element: gene;30;mmu:16956
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16956
ILK GeneProduct ensembl:ENSG00000166333 Original kegg element: gene;43;mmu:16202
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16202
APOA1 GeneProduct ensembl:ENSG00000118137 Original kegg element: gene;61;mmu:11806
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11806
GK2 GeneProduct ensembl:ENSG00000196475 Original kegg element: gene;8;mmu:14626 mmu:14933
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14626
FABP3 GeneProduct ensembl:ENSG00000121769 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14077
RXRG GeneProduct ensembl:ENSG00000143171 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20183
CPT1A GeneProduct ensembl:ENSG00000110090 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12894
RXRA GeneProduct ensembl:ENSG00000186350 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20181
SORBS1 GeneProduct ensembl:ENSG00000095637 Original kegg element: gene;38;mmu:20411
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20411
FABP4 GeneProduct ensembl:ENSG00000170323 Original kegg element: gene;40;mmu:11770
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11770
FABP5 GeneProduct ensembl:ENSG00000164687 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16592
EHHADH GeneProduct ensembl:ENSG00000113790 Original kegg element: gene;25;mmu:74147
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74147
PDPK1 GeneProduct ensembl:ENSG00000140992 Original kegg element: gene;45;mmu:18607
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
ACADL GeneProduct ensembl:ENSG00000115361 Original kegg element: gene;23;mmu:11363
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11363
ACAA1 GeneProduct ensembl:ENSG00000060971 Original kegg element: gene;21;mmu:113868 mmu:235674
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:113868

References

  1. PPARs-mediated intracellular signal transduction. Fujii H. Nihon Rinsho. 2005 Apr;63(4):565–71. PubMed Europe PMC Scholia