One-carbon metabolism and related pathways (WP3940)
Homo sapiens
This pathway shows the carbon metabolism over grey and related pathways around it. Source [https://www.genome.jp/dbget-bin/www_bget?pathway+mmu00270 KEGG]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3940 CPTAC Assay Portal].
Authors
Kristina Hanspers , Denise Slenter , Elisa Cirillo , Marvin Martens , Martina Summer-Kutmon , Egon Willighagen , Eric Weitz , and Finterly HuActivity
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
folate mediated one-carbon metabolic pathway| Label | Type | Compact Identifier | Comment |
|---|---|---|---|
| S-Adenosylhomocysteine | Metabolite | kegg.compound:C00021 | |
| Total Phospholipids | Metabolite | chebi:16247 | |
| L-Methionine | Metabolite | hmdb:HMDB0000696 | |
| 3-Sulfinoalanine | Metabolite | kegg.compound:C00606 | |
| L-Cysteine | Metabolite | kegg.compound:C00097 | |
| NADP | Metabolite | kegg.compound:C00006 | |
| Hypotaurine | Metabolite | kegg.compound:C00519 | |
| Glutathione (GSH) | Metabolite | kegg.compound:C00051 | |
| Tetrahydrofolic acid | Metabolite | kegg.compound:C00101 | |
| Phosphocholine | Metabolite | chebi:18132 | |
| Ethanolamine | Metabolite | kegg.compound:C00189 | |
| Taurocholic acid | Metabolite | kegg.compound:C05122 | |
| Glutathione disulfide (GSSG) | Metabolite | kegg.compound:C00127 | |
| 5,10-Methenyltetrahydrofolic acid | Metabolite | kegg.compound:C00445 | |
| Taurochenodesoxycholic acid | Metabolite | kegg.compound:C05465 | |
| Glutamate | Metabolite | kegg.compound:C00217 | |
| CDP-choline | Metabolite | kegg.compound:C00307 | |
| O-Phosphoethanolamine | Metabolite | kegg.compound:C00346 | |
| Phosphatidylethanolamine | Metabolite | kegg.compound:C00350 | |
| Dimethylglycine | Metabolite | kegg.compound:C01026 | |
| Betaine | Metabolite | kegg.compound:C00719 | |
| Phosphatidylcholines | Metabolite | cas:8002-43-5 | |
| L-Serine | Metabolite | kegg.compound:C00065 | |
| Taurine | Metabolite | kegg.compound:C00245 | |
| NADPH | Metabolite | kegg.compound:C00005 | |
| Sarcosine | Metabolite | kegg.compound:C00213 | |
| CDP-Ethanolamine | Metabolite | kegg.compound:C00570 | |
| 10-formyldihydrofolate | Metabolite | hmdb:HMDB0006485 | |
| 5-oxoproline | Metabolite | kegg.compound:C01879 | |
| 5-Methyltetrahydrofolic acid | Metabolite | kegg.compound:C00440 | |
| L-Cystathionine | Metabolite | kegg.compound:C02291 | |
| Folic acid | Metabolite | kegg.compound:C00504 | |
| S-Adenosylmethionine | Metabolite | kegg.compound:C00019 | |
| Homocysteine | Metabolite | kegg.compound:C05330 | |
| Glycine | Metabolite | kegg.compound:C00037 | |
| Choline | Metabolite | kegg.compound:C00114 | |
| gamma-Glutamylcysteine | Metabolite | kegg.compound:C00669 | |
| L-Serine | Metabolite | kegg.compound:C00065 | |
| Glycine | Metabolite | kegg.compound:C00037 | |
| 2-oxobutanoate | Metabolite | chebi:16763 | |
| (S)-2-Aminobutanoate | Metabolite | chebi:35619 | |
| gamma-L-Glutamyl-L-2-aminobutyrate | Metabolite | pubchem.compound:7014903 | |
| Ophthalmate | Metabolite | pubchem.compound:7018721 | |
| ETNK2 | GeneProduct | ensembl:ENSG00000143845 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:214253 |
| GPX5 | GeneProduct | ensembl:ENSG00000224586 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14780 |
| SOD1 | GeneProduct | ensembl:ENSG00000142168 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20655 |
| CSAD | GeneProduct | ensembl:ENSG00000139631 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:246277 |
| CHPT1 | GeneProduct | ensembl:ENSG00000111666 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862 |
| DHFR2 | GeneProduct | ensembl:ENSG00000178700 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13361 |
| PCYT1A | GeneProduct | ensembl:ENSG00000161217 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026 |
| MAT2A | GeneProduct | ensembl:ENSG00000168906 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:232087 |
| GSR | GeneProduct | ensembl:ENSG00000104687 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14782 |
| PCYT1B | GeneProduct | ensembl:ENSG00000102230 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:236899 |
| ETNK1 | GeneProduct | ensembl:ENSG00000139163 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320 |
| CEPT1 | GeneProduct | ensembl:ENSG00000134255 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:99712 |
| SOD3 | GeneProduct | ensembl:ENSG00000109610 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20657 |
| MAT1A | GeneProduct | ensembl:ENSG00000151224 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11720 |
| GPX7 | GeneProduct | ensembl:ENSG00000116157 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67305 |
| CTH | GeneProduct | ensembl:ENSG00000116761 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107869 |
| GSS | GeneProduct | ensembl:ENSG00000100983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14854 |
| CHDH | GeneProduct | ensembl:ENSG00000016391 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218865 |
| DNMT3A | GeneProduct | ensembl:ENSG00000119772 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13435 |
| BHMT2 | GeneProduct | ensembl:ENSG00000132840 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64918 |
| MTHFR | GeneProduct | ensembl:ENSG00000177000 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17769 |
| DNM1 | GeneProduct | ensembl:ENSG00000106976 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13429 |
| PLD1 | GeneProduct | ensembl:ENSG00000075651 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805 |
| SOD2 | GeneProduct | ensembl:ENSG00000112096 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20656 |
| GPX6 | GeneProduct | ensembl:ENSG00000198704 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75512 |
| CHKB | GeneProduct | ensembl:ENSG00000100288 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651 |
| GAD1 | GeneProduct | ensembl:ENSG00000128683 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14415 |
| CDO1 | GeneProduct | ensembl:ENSG00000129596 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12583 |
| GAD2 | GeneProduct | ensembl:ENSG00000136750 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14417 |
| GNMT | GeneProduct | ensembl:ENSG00000124713 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14711 |
| BHMT | GeneProduct | ensembl:ENSG00000145692 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12116 |
| SHMT1 | GeneProduct | ensembl:ENSG00000176974 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20425 |
| PCYT2 | GeneProduct | ensembl:ENSG00000185813 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671 |
| SARDH | GeneProduct | ensembl:ENSG00000123453 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192166 |
| GPX4 | GeneProduct | ensembl:ENSG00000167468 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:625249 |
| GPX2 | GeneProduct | ensembl:ENSG00000176153 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14776 |
| GPX1 | GeneProduct | ensembl:ENSG00000233276 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14775 |
| MTR | GeneProduct | ensembl:ENSG00000116984 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:238505 |
| GCLM | GeneProduct | ensembl:ENSG00000023909 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14630 |
| GPX3 | GeneProduct | ensembl:ENSG00000211445 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14778 |
| AHCYL1 | GeneProduct | ensembl:ENSG00000168710 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:229709 |
| CBSL | GeneProduct | ensembl:ENSG00000274276 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12411 |
| DMGDH | GeneProduct | ensembl:ENSG00000132837 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74129 |
| BAAT | GeneProduct | ensembl:ENSG00000136881 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12012 |
| SHMT2 | GeneProduct | ensembl:ENSG00000182199 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108037 |
| CHKA | GeneProduct | ensembl:ENSG00000110721 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12660 |
| TYMS | GeneProduct | ensembl:ENSG00000176890 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22171 |
| GCLC | GeneProduct | ensembl:ENSG00000001084 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14629 |
| PEMT | GeneProduct | ensembl:ENSG00000133027 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18618 |
| BCAT1 | GeneProduct | ensembl:ENSG00000060982 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030268 |
| AGXT2 | GeneProduct | ensembl:ENSG00000113492 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000089678 |
| GCLC | GeneProduct | ensembl:ENSG00000001084 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032350 |
| GSS | GeneProduct | ensembl:ENSG00000100983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027610 |
| BCAT2 | GeneProduct | ensembl:ENSG00000105552 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030826 |
| GCLM | GeneProduct | ensembl:ENSG00000023909 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028124 |