RNA interference and miRNA (WP394)

Caenorhabditis elegans

RNA interference (RNAi) refers to the silencing of gene expression by the overexpression of sequence-specific RNA molecules. This process is associated with a cellular and nuclear defense mechanism used to combat molecular parasites such as transposons and viruses. In addition, RNA interference has been shown to play a regulatory role in development. Work in C. elegans and other organisms have identified many key regulators and pathways necessary for this process. RNAi has been adapted into a tool for the study of gene function; through the use of RNAi, the expression of a target gene can be inhibited by the reverse engineering of a corresponding dsRNA.


Martijn Van Iersel , Kristina Hanspers , and Karen Yook


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Caenorhabditis elegans




Pathway Ontology

small non-coding RNA pathway


Label Type Compact URI Comment
DCR-1/Dicer GeneProduct wormbase:K12H4.8
vig-1 GeneProduct wormbase:F56D12.5
tsn-1 GeneProduct wormbase:F10G7.2
let-7 GeneProduct wormbase:let-7
lin-4 GeneProduct wormbase:lin-4
lin-41 GeneProduct wormbase:C12C8.3
lin-14 GeneProduct wormbase:T25C12.1
lin-28 GeneProduct wormbase:F02E9.2
rde-1 GeneProduct wormbase:K08H10.7
ppw-1 GeneProduct wormbase:C18E3.7
RDE-2/MUT-8 GeneProduct wormbase:F21C3.4
mut-7 GeneProduct wormbase:ZK1098.8
RDE-3/MUT-2 GeneProduct wormbase:K04F10.6
rde-4 GeneProduct wormbase:T20G5.11
rrf-1 GeneProduct wormbase:F26A3.8
rrf-2 GeneProduct wormbase:M01G12.12
ego-1 GeneProduct wormbase:F26A3.3
rrf-3 GeneProduct wormbase:F10B5.7
DRSH-1/Drosha GeneProduct wormbase:F26E4.10
PASH-1/DGCR8 GeneProduct wormbase:T22A3.5
mut-16 GeneProduct wormbase:B0379.3
ALG-1 GeneProduct wormbase:F48F7.1
ALG-2 GeneProduct wormbase:T07D3.7