Hfe effect on hepcidin production (WP3924)
Homo sapiens
new pathway, converted from mouse WP3673
For a description of pathway objects, see the WikiPathways Legend.
Authors
Kristina Hanspers and Alex PicoActivity
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Cited In
- Target and drug predictions for SARS-CoV-2 infection in hepatocellular carcinoma patients (2022).
- High Dietary Intake of Iron Might Be Harmful to Atrial Fibrillation and Modified by Genetic Diversity: A Prospective Cohort Study (2024).
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Organisms
Homo sapiensCommunities
ONTOXAnnotations
Pathway Ontology
regulatory pathway iron homeostasis pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| HFE | GeneProduct | ensembl:ENSG00000010704 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006611 |
| TMPRSS6 | GeneProduct | ensembl:ENSG00000187045 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000016942 |
| HFE2 | GeneProduct | ensembl:ENSG00000168509 | |
| HAMP | GeneProduct | ensembl:ENSG00000105697 | Hepcidin. Inhibits iron absorbtionHomology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000050440 |
| BMP6 | GeneProduct | ensembl:ENSG00000153162 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039004 |
| SMAD7 | GeneProduct | ensembl:ENSG00000101665 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025880 |
| ID1 | GeneProduct | ensembl:ENSG00000125968 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042745 |
References
- Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. Finberg KE, Whittlesey RL, Andrews NC. Blood. 2011 Apr 28;117(17):4590–9. PubMed Europe PMC Scholia