RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis (WP3873)

Drosophila melanogaster

This pathway is based on figure 7 from Read et al. When over-expressed the RIOK1 and RIOK2 proteins signal downstream of Akt to induce tumorigensis. RIOK2 also regulates signaling upstream of AKT through stimulation of TORC2 protein. In the absence of RIOK1 and RIOK2 the cell undergoes the L11 Ribosomal Stress Response due to reduction of AKT signaling which invokes p53 to stimulate the apoptosis cascade, chemosensitivity, and cell cycle arrest in the cell.


AAR&Co , Friederike Ehrhart , Kristina Hanspers , and Egon Willighagen


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Drosophila melanogaster



Pathway Ontology

cancer pathway altered stress response pathway

Disease Ontology



Label Type Compact Identifier Comment
Egfr GeneProduct ensembl:FBgn0003731
Pi3K GeneProduct ensembl:FBgn0015279
Pten GeneProduct ensembl:FBgn0026379
Akt1 GeneProduct ensembl:FBgn0010379 AKT Not Specified
foxo GeneProduct ensembl:FBgn0038197
TORC2 GeneProduct uniprot:Q3U182
RIOK1 GeneProduct ensembl:FBgn0036187
RIOK2 GeneProduct ensembl:FBgn0039306
RpL11 GeneProduct ensembl:FBgn0013325
p53 GeneProduct ensembl:FBgn0039044


  1. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. Read RD, Fenton TR, Gomez GG, Wykosky J, Vandenberg SR, Babic I, et al. PLoS Genet. 2013;9(2):e1003253. PubMed Europe PMC Scholia