RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis (WP3873)

Homo sapiens

This pathway is based on figure 7 from Read et al. When over-expressed the RIOK1 and RIOK2 proteins signal downstream of Akt to induce tumorigensis. RIOK2 also regulates signaling upstream of AKT through stimulation of the mTORC2 complex (indicated by red interactions). In the absence of RIOK1 and RIOK2 (indicated by blue interactions) the p53-dependent ribosomal stress checkpoint via RPL1 is induced.


AAR&Co , Friederike Ehrhart , Kristina Hanspers , and Egon Willighagen


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Homo sapiens



Disease Ontology

glioblastoma cancer

Pathway Ontology

altered stress response pathway altered phosphatidylinositol 3-kinase-Akt signaling pathway cancer pathway


Label Type Compact URI Comment
PTEN GeneProduct hgnc.symbol:PTEN
RIOK1 GeneProduct hgnc.symbol:RIOK1
PIK3CA GeneProduct hgnc.symbol:PIK3CA
AKT1 GeneProduct hgnc.symbol:AKT1 AKT Not Specified
RPL11 GeneProduct hgnc.symbol:RPL11
FOXO3 GeneProduct hgnc.symbol:FOXO3
RIOK2 GeneProduct hgnc.symbol:RIOK2
EGFR GeneProduct ensembl:ENSG00000146648
MTOR GeneProduct hgnc.symbol:MTOR
TP53 GeneProduct hgnc.symbol:TP53
AKT2 GeneProduct hgnc.symbol:AKT2 AKT Not Specified
AKT3 GeneProduct hgnc.symbol:AKT3 AKT Not Specified
RICTOR GeneProduct hgnc.symbol:RICTOR
MLST8 GeneProduct hgnc.symbol:MLST8
MAPKAP1 GeneProduct hgnc.symbol:MAPKAP1


  1. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. Read RD, Fenton TR, Gomez GG, Wykosky J, Vandenberg SR, Babic I, et al. PLoS Genet. 2013;9(2):e1003253. PubMed Europe PMC Scholia