Turbo design of glycolysis (WP3636)

Saccharomyces cerevisiae

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Many catabolic pathways begin with an ATP-requiring activation step, after which further metabolism yields a surplus of ATP. Such a 'turbo' principle is useful but also contains an inherent risk. This is illustrated by a detailed kinetic analysis of glycolysis in a Saccharomyces cerevisiae mutant. The model has been converted to GPML using the PathSBML plugin from PathVIsio, importing the model BIOMD0000000253 from the BioModels Database directly. The layout has been improved manually.

Authors

Anwesha Bohler and Kristina Hanspers

Activity

last edited

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Organisms

Saccharomyces cerevisiae

Communities

Annotations

Pathway Ontology

glycolysis pathway

Participants

Label Type Compact URI Comment
ADP Metabolite chebi:16761
ATP Metabolite chebi:15422
Fru 1,6 P2 Metabolite hmdb:HMDB0001058
Glc Metabolite chebi:17925
HMP Metabolite chebi:17665
Tre 6 P Metabolite chebi:18283

References

  1. The danger of metabolic pathways with turbo design. Teusink B, Walsh MC, van Dam K, Westerhoff HV. Trends Biochem Sci. 1998 May;23(5):162–9. PubMed Europe PMC Scholia