Tamoxifen metabolism (WP3264)

Bos taurus

Authors

Martina Summer-Kutmon and Friederike Ehrhart

Activity

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

breast cancer pathway cancer pathway

Disease Ontology

estrogen-receptor positive breast cancer

References

1. Quaternary ammonium-linked glucuronidation of tamoxifen by human liver microsomes and UDP-glucuronosyltransferase 1A4. Kaku T, Ogura K, Nishiyama T, Ohnuma T, Muro K, Hiratsuka A. Biochem Pharmacol. 2004 Jun 1;67(11):2093–102. PubMed Europe PMC Scholia
2. Quaternary ammonium-linked glucuronidation of trans-4-hydroxytamoxifen, an active metabolite of tamoxifen, by human liver microsomes and UDP-glucuronosyltransferase 1A4. Ogura K, Ishikawa Y, Kaku T, Nishiyama T, Ohnuma T, Muro K, et al. Biochem Pharmacol. 2006 Apr 28;71(9):1358–69. PubMed Europe PMC Scholia
3. Chemoprevention of breast cancer with selective oestrogen-receptor modulators. Jordan VC. Nat Rev Cancer. 2007 Jan;7(1):46–53. PubMed Europe PMC Scholia
4. New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer. Jordan VC. Steroids. 2007 Nov;72(13):829–42. PubMed Europe PMC Scholia
5. Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen. Lazarus P, Blevins-Primeau AS, Zheng Y, Sun D. Ann N Y Acad Sci. 2009 Feb;1155:99–111. PubMed Europe PMC Scholia