Senescence and autophagy in cancer (WP3231)

Bos taurus

Senescense and Autophagy Pathways in Cancer

Authors

Martina Summer-Kutmon and Eric Weitz

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

cellular senescence pathway autophagy pathway

Participants

Label Type Compact Identifier Comment
PIP3(16:0/16:0) Metabolite hmdb:HMDB0010147
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 ARF
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
KMT2A GeneProduct ensembl:ENSBTAG00000018093 ARF
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4297
IGFBP7 GeneProduct ensembl:ENSBTAG00000019368 ARF
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3490
IRF1 GeneProduct ensembl:ENSBTAG00000031231 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3659
SQSTM1 GeneProduct ensembl:ENSBTAG00000015591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8878
IL6 GeneProduct ensembl:ENSBTAG00000014921 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 ARF
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
CXCL8 GeneProduct ensembl:ENSBTAG00000019716 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3576
CXCL14 GeneProduct ensembl:ENSBTAG00000006694 BRAK
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9547
CDKN1A GeneProduct ensembl:ENSBTAG00000008353 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
IGF1R GeneProduct ensembl:ENSBTAG00000021527 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3480
ATG13 GeneProduct ensembl:ENSBTAG00000017325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175224
SMAD3 GeneProduct ensembl:ENSBTAG00000012599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
LAMP1 GeneProduct ensembl:ENSBTAG00000010242 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3916
IL6R GeneProduct ensembl:ENSBTAG00000018474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3570
SLC39A2 GeneProduct ensembl:ENSBTAG00000000936 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29986
ATG12 GeneProduct ensembl:ENSBTAG00000017525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9140
ATG7 GeneProduct ensembl:ENSBTAG00000035827 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10533
CDKN1A GeneProduct ensembl:ENSBTAG00000008353 P21/CIP1/WAF1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
BECN1 GeneProduct ensembl:ENSBTAG00000019914 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8678
PTEN GeneProduct ensembl:ENSBTAG00000009498 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728
CREG1 GeneProduct ensembl:ENSBTAG00000008931 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8804
MAP2K1 GeneProduct ensembl:ENSBTAG00000033983 MEK
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
JUN GeneProduct ensembl:ENSBTAG00000004037 P21/CIP1/WAF1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725
GSN GeneProduct ensembl:ENSBTAG00000019915 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2934
ATG3 GeneProduct ensembl:ENSBTAG00000009084 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64422
COL1A1 GeneProduct ensembl:ENSBTAG00000013103 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1277
VTN GeneProduct ensembl:ENSBTAG00000016151 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7448
HMGA1 GeneProduct ensembl:ENSBTAG00000034529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3159
CDKN1B GeneProduct ensembl:ENSBTAG00000018254 P27/KIP
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027
SERPINB2 GeneProduct ensembl:ENSBTAG00000023198 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5055
ING1 GeneProduct ensembl:ENSBTAG00000025211 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3621
IRF5 GeneProduct ensembl:ENSBTAG00000004989 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3663
ATG7 GeneProduct ensembl:ENSBTAG00000035827 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10533
ATG16L1 GeneProduct ensembl:ENSBTAG00000003928 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000085978
INHBA GeneProduct ensembl:ENSBTAG00000002912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624
MMP14 GeneProduct ensembl:ENSBTAG00000014824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4323
RB1CC1 GeneProduct ensembl:ENSBTAG00000000878 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000023287
IL24 GeneProduct ensembl:ENSBTAG00000007851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11009
MAP1LC3A GeneProduct ensembl:ENSBTAG00000006135 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84557
COL10A1 GeneProduct ensembl:ENSBTAG00000003078 MKK3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1300
MGC138057 GeneProduct ensembl:ENSBTAG00000038117 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83734
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 INK4a
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
CD44 GeneProduct ensembl:ENSBTAG00000011578 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:960
ULK1 GeneProduct ensembl:ENSBTAG00000012987 ATG1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8408
PIK3C3 GeneProduct ensembl:ENSBTAG00000026290 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078142
IL1A GeneProduct ensembl:ENSBTAG00000010349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
THBS1 GeneProduct ensembl:ENSBTAG00000002006 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057
MAP1LC3C GeneProduct ensembl:ENSBTAG00000012462 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:440738
IGFBP3 GeneProduct ensembl:ENSBTAG00000003994 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3486
CDC25B GeneProduct ensembl:ENSBTAG00000008436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 P16/INK4a
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
GABARAPL1 GeneProduct ensembl:ENSBTAG00000011765 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23710
BRAF GeneProduct ensembl:ENSBTAG00000021761 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673
MTOR GeneProduct ensembl:ENSBTAG00000015325 mTOR
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
MDM2 GeneProduct ensembl:ENSBTAG00000010422 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193
GRO1 GeneProduct ensembl:ENSBTAG00000037558 GROa
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2919
PLAU GeneProduct ensembl:ENSBTAG00000005947 uPA
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5328
RB1 GeneProduct ensembl:ENSBTAG00000006640 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925
LAMP2 GeneProduct ensembl:ENSBTAG00000007399 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3920
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576 MKK3
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
ING2 GeneProduct ensembl:ENSBTAG00000047706 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3622
SH3GLB1 GeneProduct ensembl:ENSBTAG00000031171 BIF1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51100
IGFBP5 GeneProduct ensembl:ENSBTAG00000007062 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3488
IL6 GeneProduct ensembl:ENSBTAG00000046456 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456
IL6ST GeneProduct ensembl:ENSBTAG00000017745 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3572
SLC39A1 GeneProduct ensembl:ENSBTAG00000011284 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27173
AKT1S1 GeneProduct ensembl:ENSBTAG00000005763 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204673
COL3A1 GeneProduct ensembl:ENSBTAG00000021466 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1281
SRC GeneProduct ensembl:ENSBTAG00000008938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
FN1 GeneProduct ensembl:ENSBTAG00000008300 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2335
E2F1 GeneProduct ensembl:ENSBTAG00000003971 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869
TP53 GeneProduct ensembl:ENSBTAG00000001069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157
MAPK14 GeneProduct ensembl:ENSBTAG00000020783 P38a
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
GABARAP GeneProduct ensembl:ENSBTAG00000014883 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11337
MAP1LC3B GeneProduct ensembl:ENSBTAG00000011632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81631
UVRAG GeneProduct ensembl:ENSBTAG00000016355 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7405
RSL1D1 GeneProduct ensembl:ENSBTAG00000014588 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26156
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
BMP2 GeneProduct ensembl:ENSBTAG00000005111 tPA
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:650
SLC39A3 GeneProduct ensembl:ENSBTAG00000017706 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29985
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 ERK
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
MAP2K3 GeneProduct ensembl:ENSBTAG00000010576 MEK6
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606
CDKN1A GeneProduct ensembl:ENSBTAG00000008353 P21/CIP1/WAF1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
SLC39A4 GeneProduct ensembl:ENSBTAG00000046026 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55630
IRF7 GeneProduct ensembl:ENSBTAG00000047680 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3665
RNASEL GeneProduct ensembl:ENSBTAG00000009091 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6041
PLAT GeneProduct ensembl:ENSBTAG00000001244 tPA
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5327
ATG14 GeneProduct ensembl:ENSBTAG00000010795 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22863
RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
FKBP8 GeneProduct ensembl:ENSBTAG00000045585 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105701
SMAD4 GeneProduct ensembl:ENSBTAG00000006919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
MLST8 GeneProduct ensembl:ENSBTAG00000009928 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167965
SERPINE1 GeneProduct ensembl:ENSBTAG00000014465 PAI1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5054
AMBRA1 GeneProduct ensembl:ENSBTAG00000004282 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55626
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 ARF
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
GABARAPL2 GeneProduct ensembl:ENSBTAG00000006550 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11345
IGF-I GeneProduct ensembl:ENSBTAG00000011082 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3479
TNFSF15 GeneProduct ensembl:ENSBTAG00000018069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9966
CDKN1A GeneProduct ensembl:ENSBTAG00000008353 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
CDKN1A GeneProduct ensembl:ENSBTAG00000008353 P21/CIP1/WAF1
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026
HRAS GeneProduct ensembl:ENSBTAG00000046644 H-RAS
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 ARF
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
ATG5 GeneProduct ensembl:ENSBTAG00000005400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9474
IFI16 GeneProduct ensembl:ENSBTAG00000011511 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3428
PIK3C3 GeneProduct ensembl:ENSBTAG00000026290 VPS34
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5289
SPARC GeneProduct ensembl:ENSBTAG00000014835 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6678
PCNA GeneProduct ensembl:ENSBTAG00000006065 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111
BCL2 GeneProduct ensembl:ENSBTAG00000019302 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596
CDKN2A GeneProduct ensembl:ENSBTAG00000034220 ARF
HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029
GSK3B GeneProduct ensembl:ENSBTAG00000048057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932
ATG5 GeneProduct ensembl:ENSBTAG00000005400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9474

References

  1. MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, et al. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5874–8. PubMed Europe PMC Scholia
  2. Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Kuilman T, Michaloglou C, Vredeveld LCW, Douma S, van Doorn R, Desmet CJ, et al. Cell. 2008 Jun 13;133(6):1019–31. PubMed Europe PMC Scholia
  3. MicroRNA 29b functions in acute myeloid leukemia. Garzon R, Heaphy CEA, Havelange V, Fabbri M, Volinia S, Tsao T, et al. Blood. 2009 Dec 17;114(26):5331–41. PubMed Europe PMC Scholia
  4. microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, et al. Blood. 2010 Apr 1;115(13):2630–9. PubMed Europe PMC Scholia
  5. miR-29b regulates migration of human breast cancer cells. Wang C, Bian Z, Wei D, Zhang J guo. Mol Cell Biochem. 2011 Jun;352(1–2):197–207. PubMed Europe PMC Scholia