Senescence and autophagy in cancer (WP3231)
Bos taurus
Senescense and Autophagy Pathways in Cancer
Authors
Martina Summer-Kutmon and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited By
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
cellular senescence pathway autophagy pathwayLabel | Type | Compact Identifier | Comment |
---|---|---|---|
PIP3(16:0/16:0) | Metabolite | hmdb:HMDB0010147 | |
CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | ARFHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
KMT2A | GeneProduct | ensembl:ENSBTAG00000018093 | ARFHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4297 |
IGFBP7 | GeneProduct | ensembl:ENSBTAG00000019368 | ARFHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3490 |
IRF1 | GeneProduct | ensembl:ENSBTAG00000031231 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3659 |
SQSTM1 | GeneProduct | ensembl:ENSBTAG00000015591 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8878 |
IL6 | GeneProduct | ensembl:ENSBTAG00000014921 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3569 |
CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | ARFHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
CXCL8 | GeneProduct | ensembl:ENSBTAG00000019716 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3576 |
CXCL14 | GeneProduct | ensembl:ENSBTAG00000006694 | BRAKHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9547 |
CDKN1A | GeneProduct | ensembl:ENSBTAG00000008353 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026 |
IGF1R | GeneProduct | ensembl:ENSBTAG00000021527 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3480 |
ATG13 | GeneProduct | ensembl:ENSBTAG00000017325 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175224 |
SMAD3 | GeneProduct | ensembl:ENSBTAG00000012599 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088 |
LAMP1 | GeneProduct | ensembl:ENSBTAG00000010242 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3916 |
IL6R | GeneProduct | ensembl:ENSBTAG00000018474 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3570 |
SLC39A2 | GeneProduct | ensembl:ENSBTAG00000000936 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29986 |
ATG12 | GeneProduct | ensembl:ENSBTAG00000017525 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9140 |
ATG7 | GeneProduct | ensembl:ENSBTAG00000035827 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10533 |
CDKN1A | GeneProduct | ensembl:ENSBTAG00000008353 | P21/CIP1/WAF1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026 |
BECN1 | GeneProduct | ensembl:ENSBTAG00000019914 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8678 |
PTEN | GeneProduct | ensembl:ENSBTAG00000009498 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5728 |
CREG1 | GeneProduct | ensembl:ENSBTAG00000008931 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8804 |
MAP2K1 | GeneProduct | ensembl:ENSBTAG00000033983 | MEKHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604 |
JUN | GeneProduct | ensembl:ENSBTAG00000004037 | P21/CIP1/WAF1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3725 |
GSN | GeneProduct | ensembl:ENSBTAG00000019915 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2934 |
ATG3 | GeneProduct | ensembl:ENSBTAG00000009084 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64422 |
COL1A1 | GeneProduct | ensembl:ENSBTAG00000013103 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1277 |
VTN | GeneProduct | ensembl:ENSBTAG00000016151 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7448 |
HMGA1 | GeneProduct | ensembl:ENSBTAG00000034529 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3159 |
CDKN1B | GeneProduct | ensembl:ENSBTAG00000018254 | P27/KIPHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1027 |
SERPINB2 | GeneProduct | ensembl:ENSBTAG00000023198 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5055 |
ING1 | GeneProduct | ensembl:ENSBTAG00000025211 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3621 |
IRF5 | GeneProduct | ensembl:ENSBTAG00000004989 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3663 |
ATG7 | GeneProduct | ensembl:ENSBTAG00000035827 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10533 |
ATG16L1 | GeneProduct | ensembl:ENSBTAG00000003928 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000085978 |
INHBA | GeneProduct | ensembl:ENSBTAG00000002912 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3624 |
MMP14 | GeneProduct | ensembl:ENSBTAG00000014824 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4323 |
RB1CC1 | GeneProduct | ensembl:ENSBTAG00000000878 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000023287 |
IL24 | GeneProduct | ensembl:ENSBTAG00000007851 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11009 |
MAP1LC3A | GeneProduct | ensembl:ENSBTAG00000006135 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:84557 |
COL10A1 | GeneProduct | ensembl:ENSBTAG00000003078 | MKK3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1300 |
MGC138057 | GeneProduct | ensembl:ENSBTAG00000038117 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:83734 |
IL1B | GeneProduct | ensembl:ENSBTAG00000001321 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553 |
CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | INK4aHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
CD44 | GeneProduct | ensembl:ENSBTAG00000011578 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:960 |
ULK1 | GeneProduct | ensembl:ENSBTAG00000012987 | ATG1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8408 |
PIK3C3 | GeneProduct | ensembl:ENSBTAG00000026290 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000078142 |
IL1A | GeneProduct | ensembl:ENSBTAG00000010349 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552 |
THBS1 | GeneProduct | ensembl:ENSBTAG00000002006 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7057 |
MAP1LC3C | GeneProduct | ensembl:ENSBTAG00000012462 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:440738 |
IGFBP3 | GeneProduct | ensembl:ENSBTAG00000003994 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3486 |
CDC25B | GeneProduct | ensembl:ENSBTAG00000008436 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:994 |
CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | P16/INK4aHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
GABARAPL1 | GeneProduct | ensembl:ENSBTAG00000011765 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23710 |
BRAF | GeneProduct | ensembl:ENSBTAG00000021761 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:673 |
MTOR | GeneProduct | ensembl:ENSBTAG00000015325 | mTORHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475 |
MDM2 | GeneProduct | ensembl:ENSBTAG00000010422 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4193 |
GRO1 | GeneProduct | ensembl:ENSBTAG00000037558 | GROaHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2919 |
PLAU | GeneProduct | ensembl:ENSBTAG00000005947 | uPAHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5328 |
RB1 | GeneProduct | ensembl:ENSBTAG00000006640 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5925 |
LAMP2 | GeneProduct | ensembl:ENSBTAG00000007399 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3920 |
MAP2K3 | GeneProduct | ensembl:ENSBTAG00000010576 | MKK3HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606 |
ING2 | GeneProduct | ensembl:ENSBTAG00000047706 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3622 |
SH3GLB1 | GeneProduct | ensembl:ENSBTAG00000031171 | BIF1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51100 |
IGFBP5 | GeneProduct | ensembl:ENSBTAG00000007062 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3488 |
IL6 | GeneProduct | ensembl:ENSBTAG00000046456 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3456 |
IL6ST | GeneProduct | ensembl:ENSBTAG00000017745 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3572 |
SLC39A1 | GeneProduct | ensembl:ENSBTAG00000011284 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27173 |
AKT1S1 | GeneProduct | ensembl:ENSBTAG00000005763 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204673 |
COL3A1 | GeneProduct | ensembl:ENSBTAG00000021466 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1281 |
SRC | GeneProduct | ensembl:ENSBTAG00000008938 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714 |
FN1 | GeneProduct | ensembl:ENSBTAG00000008300 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2335 |
E2F1 | GeneProduct | ensembl:ENSBTAG00000003971 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1869 |
TP53 | GeneProduct | ensembl:ENSBTAG00000001069 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7157 |
MAPK14 | GeneProduct | ensembl:ENSBTAG00000020783 | P38aHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432 |
TGFB1 | GeneProduct | ensembl:ENSBTAG00000020457 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040 |
GABARAP | GeneProduct | ensembl:ENSBTAG00000014883 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11337 |
MAP1LC3B | GeneProduct | ensembl:ENSBTAG00000011632 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:81631 |
UVRAG | GeneProduct | ensembl:ENSBTAG00000016355 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7405 |
RSL1D1 | GeneProduct | ensembl:ENSBTAG00000014588 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26156 |
CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
BMP2 | GeneProduct | ensembl:ENSBTAG00000005111 | tPAHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:650 |
SLC39A3 | GeneProduct | ensembl:ENSBTAG00000017706 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:29985 |
MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | ERKHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594 |
IFNG | GeneProduct | ensembl:ENSBTAG00000012529 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458 |
MAP2K3 | GeneProduct | ensembl:ENSBTAG00000010576 | MEK6HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5606 |
CDKN1A | GeneProduct | ensembl:ENSBTAG00000008353 | P21/CIP1/WAF1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026 |
SLC39A4 | GeneProduct | ensembl:ENSBTAG00000046026 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55630 |
IRF7 | GeneProduct | ensembl:ENSBTAG00000047680 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3665 |
RNASEL | GeneProduct | ensembl:ENSBTAG00000009091 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6041 |
PLAT | GeneProduct | ensembl:ENSBTAG00000001244 | tPAHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5327 |
ATG14 | GeneProduct | ensembl:ENSBTAG00000010795 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:22863 |
RAF1 | GeneProduct | ensembl:ENSBTAG00000045748 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894 |
FKBP8 | GeneProduct | ensembl:ENSBTAG00000045585 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105701 |
SMAD4 | GeneProduct | ensembl:ENSBTAG00000006919 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089 |
MLST8 | GeneProduct | ensembl:ENSBTAG00000009928 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167965 |
SERPINE1 | GeneProduct | ensembl:ENSBTAG00000014465 | PAI1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5054 |
AMBRA1 | GeneProduct | ensembl:ENSBTAG00000004282 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:55626 |
CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | ARFHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
GABARAPL2 | GeneProduct | ensembl:ENSBTAG00000006550 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:11345 |
IGF-I | GeneProduct | ensembl:ENSBTAG00000011082 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3479 |
TNFSF15 | GeneProduct | ensembl:ENSBTAG00000018069 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9966 |
CDKN1A | GeneProduct | ensembl:ENSBTAG00000008353 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026 |
CDKN1A | GeneProduct | ensembl:ENSBTAG00000008353 | P21/CIP1/WAF1HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1026 |
HRAS | GeneProduct | ensembl:ENSBTAG00000046644 | H-RASHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265 |
CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | ARFHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
ATG5 | GeneProduct | ensembl:ENSBTAG00000005400 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9474 |
IFI16 | GeneProduct | ensembl:ENSBTAG00000011511 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3428 |
PIK3C3 | GeneProduct | ensembl:ENSBTAG00000026290 | VPS34HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5289 |
SPARC | GeneProduct | ensembl:ENSBTAG00000014835 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6678 |
PCNA | GeneProduct | ensembl:ENSBTAG00000006065 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5111 |
BCL2 | GeneProduct | ensembl:ENSBTAG00000019302 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:596 |
CDKN2A | GeneProduct | ensembl:ENSBTAG00000034220 | ARFHomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1029 |
GSK3B | GeneProduct | ensembl:ENSBTAG00000048057 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2932 |
ATG5 | GeneProduct | ensembl:ENSBTAG00000005400 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9474 |
References
- MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins. Sengupta S, den Boon JA, Chen IH, Newton MA, Stanhope SA, Cheng YJ, et al. Proc Natl Acad Sci U S A. 2008 Apr 15;105(15):5874–8. PubMed Europe PMC Scholia
- Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Kuilman T, Michaloglou C, Vredeveld LCW, Douma S, van Doorn R, Desmet CJ, et al. Cell. 2008 Jun 13;133(6):1019–31. PubMed Europe PMC Scholia
- MicroRNA 29b functions in acute myeloid leukemia. Garzon R, Heaphy CEA, Havelange V, Fabbri M, Volinia S, Tsao T, et al. Blood. 2009 Dec 17;114(26):5331–41. PubMed Europe PMC Scholia
- microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, et al. Blood. 2010 Apr 1;115(13):2630–9. PubMed Europe PMC Scholia
- miR-29b regulates migration of human breast cancer cells. Wang C, Bian Z, Wei D, Zhang J guo. Mol Cell Biochem. 2011 Jun;352(1–2):197–207. PubMed Europe PMC Scholia