NRF2 pathway (WP3190)

Bos taurus

NRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.

Authors

Martina Summer-Kutmon and Elisa Cirillo

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
Ligand Metabolite chebi:48705
SLC2A1 GeneProduct ensembl:ENSBTAG00000009617 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117394
CES3 GeneProduct ensembl:ENSBTAG00000040413 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172828
ME1 GeneProduct ensembl:ENSBTAG00000005681 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065833
PRDX1 GeneProduct ensembl:ENSBTAG00000003642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117450
GSTA2 GeneProduct ensembl:ENSBTAG00000006546 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243955
SLC2A11 GeneProduct ensembl:ENSBTAG00000018647 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133460
GPX2 GeneProduct ensembl:ENSBTAG00000048112 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176153
HGF GeneProduct ensembl:ENSBTAG00000017664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000019991
UGT1A4 GeneProduct ensembl:ENSBTAG00000048275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000244474
FGF13 GeneProduct ensembl:ENSBTAG00000020194 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129682
BLVRB GeneProduct ensembl:ENSBTAG00000010508 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090013
GCLC GeneProduct ensembl:ENSBTAG00000015571 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001084
MGST3 GeneProduct ensembl:ENSBTAG00000010265 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143198
SLC7A11 GeneProduct ensembl:ENSBTAG00000034075 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151012
NFE2L2 GeneProduct ensembl:ENSBTAG00000019255 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116044
GSTA2 GeneProduct ensembl:ENSBTAG00000006546 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174156
SLC2A13 GeneProduct ensembl:ENSBTAG00000043962 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000151229
TXN GeneProduct ensembl:ENSBTAG00000002953 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136810
ABCC4 GeneProduct ensembl:ENSBTAG00000046611 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125257
ECSOD GeneProduct ensembl:ENSBTAG00000013980 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109610
SLC2A9 GeneProduct ensembl:ENSBTAG00000039197 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109667
GPX3 GeneProduct ensembl:ENSBTAG00000043553 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000211445
ADH7 GeneProduct ensembl:ENSBTAG00000015729 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196344
EPHA3 GeneProduct ensembl:ENSBTAG00000006811 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000044524
GSR GeneProduct ensembl:ENSBTAG00000007115 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104687
HSP90AB1 GeneProduct ensembl:ENSBTAG00000047699 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096384
SLC2A3 GeneProduct ensembl:ENSBTAG00000004556 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173262
PGD GeneProduct ensembl:ENSBTAG00000013527 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142657
ALDH3A1 GeneProduct ensembl:ENSBTAG00000021113 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108602
CYP2A6 GeneProduct ensembl:ENSBTAG00000047815 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000255974
PPARD GeneProduct ensembl:ENSBTAG00000017542 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112033
CBR3 GeneProduct ensembl:ENSBTAG00000018688 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159231
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
G6PD GeneProduct ensembl:ENSBTAG00000019512 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160211
TXNRD1 GeneProduct ensembl:ENSBTAG00000013912 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198431
TGFB2 GeneProduct ensembl:ENSBTAG00000005359 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000092969
GSTP1 GeneProduct ensembl:ENSBTAG00000003548 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000084207
CES5A GeneProduct ensembl:ENSBTAG00000011164 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159398
PTGR1 GeneProduct ensembl:ENSBTAG00000011027 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106853
GSTA2 GeneProduct ensembl:ENSBTAG00000006546 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182793
UGT1A1 GeneProduct ensembl:ENSBTAG00000026181 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000241635
PRDX6 GeneProduct ensembl:ENSBTAG00000004855 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117592
HSP90AA1 GeneProduct ensembl:ENSBTAG00000006270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000080824
GGT1 GeneProduct ensembl:ENSBTAG00000046900 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100031
GSTA4 GeneProduct ensembl:ENSBTAG00000004288 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170899
NQO1 GeneProduct ensembl:ENSBTAG00000020632 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181019
DNAJB1 GeneProduct ensembl:ENSBTAG00000045858 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132002
CES1 GeneProduct ensembl:ENSBTAG00000011021 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198848
CES4A GeneProduct ensembl:ENSBTAG00000038325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172824
TGFA GeneProduct ensembl:ENSBTAG00000000783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163235
GSTT1 GeneProduct ensembl:ENSBTAG00000040298 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099984
UGT2B7 GeneProduct ensembl:ENSBTAG00000040337 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171234
SLC2A10 GeneProduct ensembl:ENSBTAG00000002942 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197496
SLC2A12 GeneProduct ensembl:ENSBTAG00000019002 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146411
GSTA2 GeneProduct ensembl:ENSBTAG00000006546 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000244067
GCLM GeneProduct ensembl:ENSBTAG00000007842 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000023909
ABCC5 GeneProduct ensembl:ENSBTAG00000017666 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114770
MAFF GeneProduct ensembl:ENSBTAG00000021435 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185022
GGFBPP5 GeneProduct ensembl:ENSBTAG00000004150 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157168
SLC2A5 GeneProduct ensembl:ENSBTAG00000007302 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142583
MGST2 GeneProduct ensembl:ENSBTAG00000021779 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000085871
SERPINA1 GeneProduct ensembl:ENSBTAG00000018843 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197249
SQSTM1 GeneProduct ensembl:ENSBTAG00000015591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161011
EGR1 GeneProduct ensembl:ENSBTAG00000010069 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120738
CES2 GeneProduct ensembl:ENSBTAG00000005093 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172831
SLC2A4 GeneProduct ensembl:ENSBTAG00000009190 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181856
SLC2A2 GeneProduct ensembl:ENSBTAG00000005386 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163581
UGT1A3 GeneProduct ensembl:ENSBTAG00000048275 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000243135
SLC2A6 GeneProduct ensembl:ENSBTAG00000001824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160326
SLC2A8 GeneProduct ensembl:ENSBTAG00000006957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136856
FTL GeneProduct ensembl:ENSBTAG00000019709 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000087086
EPHA2 GeneProduct ensembl:ENSBTAG00000000815 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142627
HMOX1 GeneProduct ensembl:ENSBTAG00000015582 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100292
MAFG GeneProduct ensembl:ENSBTAG00000000040 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197063
HBEGF GeneProduct ensembl:ENSBTAG00000021766 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113070
HSPA1A GeneProduct ensembl:ENSBTAG00000025441 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204389
KEAP1 GeneProduct ensembl:ENSBTAG00000003543 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079999
TGFBR2 GeneProduct ensembl:ENSBTAG00000019832 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163513
SLC2A3 GeneProduct ensembl:ENSBTAG00000004556 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000059804
PDGFB GeneProduct ensembl:ENSBTAG00000021697 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311
AGER GeneProduct ensembl:ENSBTAG00000014420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204305
CYP4A11 GeneProduct ensembl:ENSBTAG00000000229 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187048
RXRA GeneProduct ensembl:ENSBTAG00000017851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186350
GSTM3 GeneProduct ensembl:ENSBTAG00000001842 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134202
GSTM1 GeneProduct ensembl:ENSBTAG00000031788 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168765
SLC5A2 GeneProduct ensembl:ENSBTAG00000010096 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140675
SGLT1 GeneProduct ensembl:ENSBTAG00000012851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100170
SLC5A4 GeneProduct ensembl:ENSBTAG00000008117 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100191
SLC5A10 GeneProduct ensembl:ENSBTAG00000003700 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154025
SLC5A9 GeneProduct ensembl:ENSBTAG00000014225 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000117834
SLC5A6 GeneProduct ensembl:ENSBTAG00000006832 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138074
SLC5A11 GeneProduct ensembl:ENSBTAG00000003467 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000158865
SLC5A12 GeneProduct ensembl:ENSBTAG00000021858 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148942
SLC5A7 GeneProduct ensembl:ENSBTAG00000004352 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115665
SMCT1 GeneProduct ensembl:ENSBTAG00000011525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000256870
SLC5A5 GeneProduct ensembl:ENSBTAG00000015830 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105641
SLC6A2 GeneProduct ensembl:ENSBTAG00000003353 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103546
SLC6A1 GeneProduct ensembl:ENSBTAG00000005857 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157103
SLC6A4 GeneProduct ensembl:ENSBTAG00000019349 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108576
SLC6A11 GeneProduct ensembl:ENSBTAG00000038962 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132164
SLC6A9 GeneProduct ensembl:ENSBTAG00000006043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196517
SLC6A6 GeneProduct ensembl:ENSBTAG00000011088 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131389
SLC6A13 GeneProduct ensembl:ENSBTAG00000014525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000010379
SLC6A3 GeneProduct ensembl:ENSBTAG00000015843 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142319
SLC6A7 GeneProduct ensembl:ENSBTAG00000000910 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000011083
SLC6A8 GeneProduct ensembl:ENSBTAG00000009959 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130821
SLC6A5 GeneProduct ensembl:ENSBTAG00000014300 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165970
SLC6A16 GeneProduct ensembl:ENSBTAG00000030543 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000063127
SLC6A15 GeneProduct ensembl:ENSBTAG00000018432 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072041
SLC6A18 GeneProduct ensembl:ENSBTAG00000012559 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164363
SLC6A20 GeneProduct ensembl:ENSBTAG00000031340 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000163817
SLC6A17 GeneProduct ensembl:ENSBTAG00000001981 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197106
SLC6A19 GeneProduct ensembl:ENSBTAG00000045695 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174358
SLC39A2 GeneProduct ensembl:ENSBTAG00000000936 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165794
SLC39A1 GeneProduct ensembl:ENSBTAG00000011284 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143570
SLC39A4 GeneProduct ensembl:ENSBTAG00000046026 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000147804
SLC39A10 GeneProduct ensembl:ENSBTAG00000016782 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196950
SLC39A9 GeneProduct ensembl:ENSBTAG00000017811 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000029364
SLC39A6 GeneProduct ensembl:ENSBTAG00000000998 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141424
SLC39A11 GeneProduct ensembl:ENSBTAG00000018837 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133195
SLC39A12 GeneProduct ensembl:ENSBTAG00000015525 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000148482
SLC39A3 GeneProduct ensembl:ENSBTAG00000017706 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141873
SLC39A7 GeneProduct ensembl:ENSBTAG00000008191 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112473
SLC39A8 GeneProduct ensembl:ENSBTAG00000005668 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138821
SLC39A5 GeneProduct ensembl:ENSBTAG00000002799 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139540
SLC39A13 GeneProduct ensembl:ENSBTAG00000019436 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165915
SLC39A14 GeneProduct ensembl:ENSBTAG00000019225 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104635

References

  1. The GI-GPx gene is a target for Nrf2. Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohé R. Mol Cell Biol. 2005 Jun;25(12):4914–23. PubMed Europe PMC Scholia
  2. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Hayes JD, McMahon M. Trends Biochem Sci. 2009 Apr;34(4):176–88. PubMed Europe PMC Scholia
  3. Nrf2 target genes are induced under marginal selenium-deficiency. Müller M, Banning A, Brigelius-Flohé R, Kipp A. Genes Nutr. 2010 Dec;5(4):297–307. PubMed Europe PMC Scholia
  4. From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Bock KW. Biochem Pharmacol. 2011 Jul 1;82(1):9–16. PubMed Europe PMC Scholia
  5. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia