Gastric acid production (WP3172)

Bos taurus

Gastric acid forms a protective buffer against pathogenic agents. It is also essential in the digestion of the food. The stomach wall is protected to the high acidity by a mucus layer and bicarbonate ions.

Authors

Martina Summer-Kutmon and Alex Pico

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Cell Type Ontology

parietal cell stomach enteroendocrine cell

Participants

Label Type Compact URI Comment
Histamine Metabolite chemspider:753
Bicarbonate ions Metabolite chemspider:749
potassium chloride Metabolite chemspider:4707
Sodium Chloride Metabolite chemspider:5044
Acetylcholine Metabolite chemspider:182
hydrochloric acid Metabolite chemspider:307
MUC6 GeneProduct ensembl:ENSBTAG00000037783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4588
GAST GeneProduct ensembl:ENSBTAG00000017663 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P01350
CCK GeneProduct ensembl:ENSBTAG00000013027 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:885
VIP GeneProduct ensembl:ENSBTAG00000013400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7432
GIF GeneProduct ensembl:ENSBTAG00000012057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P27352
GRP GeneProduct ensembl:ENSBTAG00000004796 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2922

References

  1. CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion. Sandvik AK, Waldum HL. Am J Physiol. 1991 Jun;260(6 Pt 1):G925-8. PubMed Europe PMC Scholia
  2. Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. Allen A, Garner A. Gut. 1980 Mar;21(3):249–62. PubMed Europe PMC Scholia
  3. Demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a “mucus-bicarbonate” barrier. Williams SE, Turnberg LA. Gut. 1981 Feb;22(2):94–6. PubMed Europe PMC Scholia
  4. Human gastric mucin. Identification of a unique species by expression cloning. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, et al. J Biol Chem. 1993 Mar 15;268(8):5879–85. PubMed Europe PMC Scholia