Gastric acid production (WP3172)

Bos taurus

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Gastric acid forms a protective buffer against pathogenic agents. It is also essential in the digestion of the food. The stomach wall is protected to the high acidity by a mucus layer and bicarbonate ions.

Authors

Martina Summer-Kutmon and Alex Pico

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited By

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

regulatory pathway

Cell Type Ontology

parietal cell stomach enteroendocrine cell

Participants

Label Type Compact Identifier Comment
Histamine Metabolite chemspider:753
Bicarbonate ions Metabolite chemspider:749
potassium chloride Metabolite chemspider:4707
Sodium Chloride Metabolite chemspider:5044
Acetylcholine Metabolite chemspider:182
hydrochloric acid Metabolite chemspider:307
MUC6 GeneProduct ensembl:ENSBTAG00000037783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4588
GAST GeneProduct ensembl:ENSBTAG00000017663 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P01350
CCK GeneProduct ensembl:ENSBTAG00000013027 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:885
VIP GeneProduct ensembl:ENSBTAG00000013400 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7432
GIF GeneProduct ensembl:ENSBTAG00000012057 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P27352
GRP GeneProduct ensembl:ENSBTAG00000004796 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2922

References

  1. CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion. Sandvik AK, Waldum HL. Am J Physiol. 1991 Jun;260(6 Pt 1):G925-8. PubMed Europe PMC Scholia
  2. Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection. Allen A, Garner A. Gut. 1980 Mar;21(3):249–62. PubMed Europe PMC Scholia
  3. Demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a “mucus-bicarbonate” barrier. Williams SE, Turnberg LA. Gut. 1981 Feb;22(2):94–6. PubMed Europe PMC Scholia
  4. Human gastric mucin. Identification of a unique species by expression cloning. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, et al. J Biol Chem. 1993 Mar 15;268(8):5879–85. PubMed Europe PMC Scholia