Neurotransmitter clearance in synaptic cleft (WP3165)

Bos taurus

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Neurotransmitter released in the synaptic cleft binds to specific receptors on the post-synaptic cell and the excess of the neurotransmitter is cleared to prevent over activation of the post-synaptic cell. The neurotransmitter is cleared by either re-uptake by the pre-synaptic neuron, diffusion in the perisynaptic area, uptake by astrocytes surrounding the synaptic cleft or enzymatic degradation of the neurotransmitter.
This topic will be annotated in a future release.Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=112311

For a description of pathway objects, see the WikiPathways Legend.

Authors

Martina Summer-Kutmon , Elisa Cirillo , Eric Weitz , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

signaling pathway signaling pathway pertinent to the brain and nervous system

Participants

Label Type Compact URI Comment
HIAA Metabolite chebi:27823
H₂O Metabolite chebi:15377
CDNB Metabolite chebi:34718
FAD [mitochondrialouter membrane] Metabolite chebi:16238
5HT Metabolite chebi:28790
NH3 Metabolite chebi:16134
H₂O₂ Metabolite chebi:16240
NAD+ Metabolite chebi:15846
Na+ Metabolite chebi:29101
AdoMet Metabolite chebi:15414
O₂ Metabolite chebi:15379
AcCho Metabolite chebi:15355
DA Metabolite chebi:18243
5HT-N-CH3 Metabolite chebi:3210
H+ Metabolite chebi:15378
HIALD Metabolite chebi:50157
Cho Metabolite chebi:15354
acetate Metabolite chebi:30089
HCYS Metabolite chebi:17230
NAd Metabolite chebi:18357
AdoHcy Metabolite chebi:16680
NADH Metabolite chebi:16908
ALDH2 Protein ensembl:ENSBTAG00000008743 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P05091
MAOA Protein ensembl:ENSBTAG00000016206 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21397
SLC22A2 Protein ensembl:ENSBTAG00000009583 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15244
COMT Protein ensembl:ENSBTAG00000019516 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P21964
SLC6A3 Protein ensembl:ENSBTAG00000015843 HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q01959

References

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