Extracellular vesicle-mediated signaling in recipient cells (WP3161)

Bos taurus

Protein sorting during formation of multivesicular bodies results in packaging of key molecules in exosomes. Exosomes bound-signaling ligands once released from host cells interacts with the receptors on the recipient cells to induce downstream signaling cascades pivotal in the initiation and progression of cancer. This horizontal transfer of proteomic content of exosomes can mediate signaling pathways including Wnt, PI3K and TGF-beta in recipient cells.

Authors

Martina Summer-Kutmon and Susan Coort

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Disease Ontology

cancer nervous system disease

Pathway Ontology

signaling pathway

Participants

Label Type Compact URI Comment
SMAD4 GeneProduct ensembl:ENSBTAG00000006919 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4089
SMAD2 GeneProduct ensembl:ENSBTAG00000039916 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4087
SMAD3 GeneProduct ensembl:ENSBTAG00000012599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4088
WNT3A GeneProduct ensembl:ENSBTAG00000039397 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:89780
WNT5A GeneProduct ensembl:ENSBTAG00000020221 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7474
ERBB2 GeneProduct ensembl:ENSBTAG00000021798 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2064
EGFR GeneProduct ensembl:ENSBTAG00000011628 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1956
MFGE8 GeneProduct ensembl:ENSBTAG00000003300 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4240
TSPAN8 GeneProduct ensembl:ENSBTAG00000019425 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7103
DKK4 GeneProduct ensembl:ENSBTAG00000000226 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27121
TGFA GeneProduct ensembl:ENSBTAG00000000783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7039
TGFB1 GeneProduct ensembl:ENSBTAG00000020457 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7040
PROM1 GeneProduct ensembl:ENSBTAG00000013736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8842
AKT1 GeneProduct ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
MTOR GeneProduct ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
HGF GeneProduct ensembl:ENSBTAG00000017664 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3082
C-MET GeneProduct ensembl:ENSBTAG00000006161 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4233
PIK3R5 GeneProduct ensembl:ENSBTAG00000005978 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:23533
HRAS GeneProduct ensembl:ENSBTAG00000046644 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
RAF1 GeneProduct ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
TGFBR1 GeneProduct ensembl:ENSBTAG00000018035 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7046
TGFBR3 GeneProduct ensembl:ENSBTAG00000024269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7049
TGFB2 GeneProduct ensembl:ENSBTAG00000005359 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7042
TGFB3 GeneProduct ensembl:ENSBTAG00000012004 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7043
APC GeneProduct ensembl:ENSBTAG00000018852 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:324
AXIN1 GeneProduct ensembl:ENSBTAG00000016577 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8312
CTNNB1 GeneProduct ensembl:ENSBTAG00000016420 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1499
NRAS Protein ensembl:ENSBTAG00000046797 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
TGFBR2 Protein ensembl:ENSBTAG00000019832 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7048

References

  1. Extracellular vesicles including exosomes are mediators of signal transduction: are they protective or pathogenic? Gangoda L, Boukouris S, Liem M, Kalra H, Mathivanan S. Proteomics. 2015 Jan;15(2–3):260–71. PubMed Europe PMC Scholia