IL1 and megakaryotyces in obesity (WP3160)

Bos taurus

Schematic of the effects of interleukin (IL)1-beta/IL1R1 on megakaryocyte and platelet function. A high fat diet will cause megakaryocytes to produce platelets with an increase in both inflammatory and thrombotic genes. IL1-beta in circulation as a result of increased body weight will bind IL1R1 on megakaryocytes. This interaction leads to the activation of the nuclear factor (NF)kB, PI3K/Akt, and mitogen activated protein kinase (MAPK) (ERK and p38) pathways. As a result, there is an increase in megakarycoyte maturation, including increased adhesion, increases in ploidy, and increases in mRNA production of inflammatory and thrombotic genes. IL1-beta can also bind IL1R1 on platelets and either enhance aggregation induced by agonists or promote adhesion and heterotypic aggregate formation. Some of the data used to create the pathway was generated in mouse (noted in pathway), however the pathway represents human homologs of those genes.

Authors

Martina Summer-Kutmon and Jonathan Mélius

Activity

last edited

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Organisms

Bos taurus

Communities

Annotations

Disease Ontology

overnutrition

Pathway Ontology

obesity pathway

Participants

Label Type Compact URI Comment
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554
F2R GeneProduct ensembl:ENSBTAG00000020199 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2149
ICAM1 GeneProduct ensembl:ENSBTAG00000010303 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3383
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
TIMP2 GeneProduct ensembl:ENSBTAG00000010899 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7077
SELENBP1 GeneProduct ensembl:ENSBTAG00000008091 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8991
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4318
PLA2G7 GeneProduct ensembl:ENSBTAG00000019315 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7941
IRAK1 GeneProduct ensembl:ENSBTAG00000016085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3654
IL18 GeneProduct ensembl:ENSBTAG00000000277 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3606
MYD88 GeneProduct ensembl:ENSBTAG00000000563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4615
TIMP1 GeneProduct ensembl:ENSBTAG00000005043 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7076
CCR3 GeneProduct ensembl:ENSBTAG00000001338 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1232
PIK3CA GeneProduct ensembl:ENSBTAG00000009232 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
NLRP3 GeneProduct ensembl:ENSBTAG00000001273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:114548
FCER1A GeneProduct ensembl:ENSBTAG00000012887 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2205
MYD88 GeneProduct ensembl:ENSBTAG00000000563 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4615
F2 GeneProduct ensembl:ENSBTAG00000007148 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2147
IFNG GeneProduct ensembl:ENSBTAG00000012529 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3458
S100A9 GeneProduct ensembl:ENSBTAG00000006505 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6280
HBEGF GeneProduct ensembl:ENSBTAG00000021766 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1839
CCL2 GeneProduct ensembl:ENSBTAG00000037811 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6347
TLR2 GeneProduct ensembl:ENSBTAG00000008008 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7097
MMP9 GeneProduct ensembl:ENSBTAG00000020676 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4318
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4790
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3553
IL1R1 GeneProduct ensembl:ENSBTAG00000005273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3554

References

  1. Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, et al. Arterioscler Thromb Vasc Biol. 2014 Mar;34(3):552–64. PubMed Europe PMC Scholia