FSH signaling pathway (WP3158)

Bos taurus

The Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH) and Chorionic Gonadotropin. FSH controls the growth and maturation of follicles in the females and spermatogenesis in males. FSH is a heterodimer and shares a common alpha sub-unit with the other glycoprotein hormones in its family and has a specific beta subunit that confers receptor specificity and biological activity to the hormone. FSH acts through the FSH receptor (FSHR), a G protein coupled receptor that is expressed exclusively on the granulosa cells of ovaries and Sertoli cells of the testis in humans. FSH signaling involves activation of adenylyl cyclase activity and the increased production of cAMP. This activates the cAMP dependent protein kinases such as PKA, PKB and PKC that, in turn, lead to the phosphorylation of specific transcription factors such as cAMP response element binding protein (CREB) and Forkhead box protein O1 (FOXO1). In addition to activation of PI3K/Akt module, PKA also induces p38 mapk which, in turn, controls other kinase cascades. Activated Akt also induces the mTOR axis that stimulates mRNA translation by phosphorylating p70 S6 kinase and, consequently, the 40 S ribosomal protein S6 that results in the activation of eukaryotic initiation factor (eIF) 4E. It also indirectly aids in the activation of extracellular signal-regulated protein kinases (ERKs). FSH induces important genes required for steroidogenesis as well as growth and maturation of germ cells. The important target genes include aromatase (CYP19A1), the lutenizing hormone receptor (LHR) and the vascular endothelial growth factor (VEGF). Please access this pathway at [http://www.netpath.org/netslim/fsh_pathway.html NetSlim] database. If you use this pathway, please cite the following paper: Telikicherla, D., Ambekar, A., Palapetta, S. M., Dwivedi, S. B., Raju, R., Sharma, J., Prasad, T. S. K., Ramachandra, Y. L., Mohan, S. S., Maharudraiah, J., Mukherjee, S. and Pandey, A. (2011). A comprehensive curated resource for Follicle Stimulating Hormone signaling. BMC Research Notes. 4, 408.

Authors

Martina Summer-Kutmon and Egon Willighagen

Activity

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Organisms

Bos taurus

Communities

Annotations

Cell Type Ontology

granulosa cell gonadtroph

Pathway Ontology

follicle-stimulating hormone signaling pathway

Participants

Label Type Compact URI Comment
MAPK1 Protein ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5594
FSHB Protein ensembl:ENSBTAG00000039236 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2488
FSHR Protein ensembl:ENSBTAG00000032424 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2492
CGA Protein ensembl:ENSBTAG00000016138 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1081
MAPK3 Protein ensembl:ENSBTAG00000016156 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
AKT1 Protein ensembl:ENSBTAG00000017636 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:207
RPS6 Protein ensembl:ENSBTAG00000014449 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6194
TSC2 Protein ensembl:ENSBTAG00000020617 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7249
CREB1 Protein ensembl:ENSBTAG00000005474 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1385
HIST3H3 Protein ensembl:ENSBTAG00000031721 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:8290
RPS6KB1 Protein ensembl:ENSBTAG00000016851 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6198
FOXO1 Protein ensembl:ENSBTAG00000044105 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2308
MAPK14 Protein ensembl:ENSBTAG00000020783 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
GRK6 Protein ensembl:ENSBTAG00000043994 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2870
RPS6KB2 Protein ensembl:ENSBTAG00000009175 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6199
RAF1 Protein ensembl:ENSBTAG00000045748 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
EIF4EBP1 Protein ensembl:ENSBTAG00000027654 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1978
SRC Protein ensembl:ENSBTAG00000008938 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6714
SGK1 Protein ensembl:ENSBTAG00000004269 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6446
MTOR Protein ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2475
APPL1 Protein ensembl:ENSBTAG00000006824 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:26060
PRKCA Protein ensembl:ENSBTAG00000001061 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5578
PRKACA Protein ensembl:ENSBTAG00000006642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5566
RHEB Protein ensembl:ENSBTAG00000031861 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6009

References

  1. NetPath: a public resource of curated signal transduction pathways. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GSS, Venugopal AK, et al. Genome Biol. 2010 Jan 12;11(1):R3. PubMed Europe PMC Scholia