NOD pathway (WP3147)

Bos taurus

The NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importance of these molecules is underscored by the fact that mutations in the gene that encodes NOD2 occur in a subpopulation of patients with Crohn's disease, and NOD1 has also been shown to participate in host defence against infection with Helicobacter pylori.

Authors

Martina Summer-Kutmon and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

NOD-like receptor signaling pathway

Participants

Label Type Compact URI Comment
NLRP1 GeneProduct ensembl:ENSBTAG00000020433 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091592
ACAP1 GeneProduct ensembl:ENSBTAG00000010527 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072818
ERBB2IP GeneProduct ensembl:ENSBTAG00000000415 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112851
NOD2 GeneProduct ensembl:ENSBTAG00000020936 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167207
AAMP GeneProduct ensembl:ENSBTAG00000003927 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127837
CARD9 GeneProduct ensembl:ENSBTAG00000006572 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187796
RELA GeneProduct ensembl:ENSBTAG00000013895 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173039
NLRP7 GeneProduct ensembl:ENSBTAG00000047473 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167634
CARD6 GeneProduct ensembl:ENSBTAG00000014374 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132357
CASP7 GeneProduct ensembl:ENSBTAG00000006615 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165806
RIPK2 GeneProduct ensembl:ENSBTAG00000015271 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104312
CASP8 GeneProduct ensembl:ENSBTAG00000015718 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064012
NLRP12 GeneProduct ensembl:ENSBTAG00000038149 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142405
IL1B GeneProduct ensembl:ENSBTAG00000001321 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
NLRP2 GeneProduct ensembl:ENSBTAG00000047473 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000022556
NLRP3 GeneProduct ensembl:ENSBTAG00000001273 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162711
CASP9 GeneProduct ensembl:ENSBTAG00000002472 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132906
SUGT1 GeneProduct ensembl:ENSBTAG00000002137 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000165416
IL18 GeneProduct ensembl:ENSBTAG00000000277 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150782
DUOX2 GeneProduct ensembl:ENSBTAG00000016234 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140279
NAIP GeneProduct ensembl:ENSBTAG00000003326 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4671
PRDM1 GeneProduct ensembl:ENSBTAG00000000816 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000057657
IKBKB GeneProduct ensembl:ENSBTAG00000007599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104365
NLRC4 GeneProduct ensembl:ENSBTAG00000008223 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000091106
BIKBA GeneProduct ensembl:ENSBTAG00000016683 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100906
PYCARD GeneProduct ensembl:ENSBTAG00000020535 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103490
CASP13 GeneProduct ensembl:ENSBTAG00000020884 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000137757
COPS6 GeneProduct ensembl:ENSBTAG00000002871 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168090
NOD1 GeneProduct ensembl:ENSBTAG00000038235 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106100
HSP90AA1 GeneProduct ensembl:ENSBTAG00000006270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000080824
RAC1 GeneProduct ensembl:ENSBTAG00000009233 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136238
MEFV GeneProduct ensembl:ENSBTAG00000019123 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103313
CHUK GeneProduct ensembl:ENSBTAG00000007591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213341

References

  1. Signalling pathways and molecular interactions of NOD1 and NOD2. Strober W, Murray PJ, Kitani A, Watanabe T. Nat Rev Immunol. 2006 Jan;6(1):9–20. PubMed Europe PMC Scholia