Trans-sulfuration pathway (WP3145)

Bos taurus

Open in new tab
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.

Authors

Martina Summer-Kutmon

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

glutathione metabolic pathway

Participants

Label Type Compact URI Comment
Tetrahydrofolate (THF) Metabolite kegg.compound:C00101
L-Methionine Metabolite kegg.compound:C00073
5-Methyl-THF Metabolite kegg.compound:C00440
L-Homocysteine Metabolite kegg.compound:C00155
S-Adenosylmethionine (SAMe) Metabolite kegg.compound:C00019
S-Adenosylhomocysteine (SAH) Metabolite kegg.compound:C00021
L-Cysteine Metabolite kegg.compound:C00097
Glutathione Metabolite kegg.compound:C00051
Taurine Metabolite kegg.compound:C00245
L-Glutamate Metabolite kegg.compound:C00025
Pyruvate Metabolite kegg.compound:C00022
ATP Metabolite kegg.compound:C00002
ADP Metabolite kegg.compound:C00008
Phosphate Metabolite kegg.compound:C00009
MTR GeneProduct ensembl:ENSBTAG00000012251 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4548
MAT2B GeneProduct ensembl:ENSBTAG00000012350 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:27430
DNMT1 GeneProduct ensembl:ENSBTAG00000002736 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1786
AHCY GeneProduct ensembl:ENSBTAG00000018101 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:191
CBS GeneProduct ensembl:ENSBTAG00000000160 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:875
CTH GeneProduct ensembl:ENSBTAG00000014791 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1491
CTH GeneProduct ensembl:ENSBTAG00000014791 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1491
GOT1 GeneProduct ensembl:ENSBTAG00000011960 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2805
MPST GeneProduct ensembl:ENSBTAG00000030648 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4357
GCLM GeneProduct ensembl:ENSBTAG00000007842 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2730
CSAD GeneProduct ensembl:ENSBTAG00000007829 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:51380
GCLM GeneProduct ensembl:ENSBTAG00000007842 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2730

References

  1. Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity. Beger RD, Sun J, Schnackenberg LK. Toxicol Appl Pharmacol. 2010 Mar 1;243(2):154–66. PubMed Europe PMC Scholia