SREBF and miR33 in cholesterol and lipid homeostasis (WP3137)

Bos taurus

This pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.

Authors

Martina Summer-Kutmon , Linda Rieswijk , and Lars Willighagen

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

homeostasis pathway

Participants

Label Type Compact URI Comment
SREBF1 GeneProduct ensembl:ENSBTAG00000007884 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072310
PPARGC1A GeneProduct ensembl:ENSBTAG00000017024 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109819
FASN GeneProduct ensembl:ENSBTAG00000015980 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2194
SIRT6 GeneProduct ensembl:ENSBTAG00000019909 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077463
HMGCR GeneProduct ensembl:ENSBTAG00000007840 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161
SIRT1 GeneProduct ensembl:ENSBTAG00000014023 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096717
MTOR GeneProduct ensembl:ENSBTAG00000015325 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793
SCD GeneProduct ensembl:ENSBTAG00000047957 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6319
NR1H3 GeneProduct ensembl:ENSBTAG00000010681 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000025434
PPARA GeneProduct ensembl:ENSBTAG00000008063 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186951
MED15 GeneProduct ensembl:ENSBTAG00000018048 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099917
SREBF2 GeneProduct ensembl:ENSBTAG00000014265 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198911
HMGCS1 GeneProduct ensembl:ENSBTAG00000011839 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112972
LDLR GeneProduct ensembl:ENSBTAG00000012314 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130164
ABCA1 GeneProduct ensembl:ENSBTAG00000020661 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:19
PRKAA1 GeneProduct ensembl:ENSBTAG00000000013 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5562

References

  1. Receptor feasts on sugar and cholesterol. Rodgers JT, Puigserver P. Nat Med [Internet]. 2007 Feb;13(2):128–9. Available from: http://dx.doi.org/10.1038/nm0207-128 DOI Scholia
  2. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, et al. Nature. 2006 Aug 10;442(7103):700–4. PubMed Europe PMC Scholia
  3. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, et al. EMBO J. 2007 Apr 4;26(7):1913–23. PubMed Europe PMC Scholia
  4. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, et al. EMBO J. 2007 Jul 11;26(13):3169–79. PubMed Europe PMC Scholia
  5. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Rodgers JT, Puigserver P. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12861–6. PubMed Europe PMC Scholia
  6. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. Nature. 2007 Nov 29;450(7170):736–40. PubMed Europe PMC Scholia
  7. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, et al. Genes Dev. 2010 Jul 1;24(13):1403–17. PubMed Europe PMC Scholia
  8. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF, et al. J Biol Chem. 2010 Oct 29;285(44):33652–61. PubMed Europe PMC Scholia
  9. MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo. Horie T, Ono K, Horiguchi M, Nishi H, Nakamura T, Nagao K, et al. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17321–6. PubMed Europe PMC Scholia