Electron transport chain (WP295)
Mus musculus
An electron transport chain(ETC) couples a chemical reaction between an electron donor (such as NADH) and an electron acceptor (such as O₂) to the transfer of H⁺ ions across a membrane, through a set of mediating biochemical reactions. These H⁺ ions are used to produce adenosine triphosphate (ATP), the main energy intermediate in living organisms, as they move back across the membrane. In mitochondria, it is the conversion of oxygen to water, NADH to NAD+ and succinate to fumarate that drives the transfer of H⁺ ions. Source: Wikipedia
For a description of pathway objects, see the WikiPathways Legend.
Authors
Kdahlquist , Meredith Braymer , Alex Pico , Christine Chichester , Kristina Hanspers , Egon Willighagen , Martina Summer-Kutmon , Alex Papachristodoulou , Friederike Ehrhart , and Eric WeitzActivity
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Cited In
- Chronic inflammatory arthritis drives systemic changes in circadian energy metabolism (2022).
- A Shared Transcriptional Identity for Forebrain and Dentate Gyrus Neural Stem Cells from Embryogenesis to Adulthood (2022).
- Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways (2021).
- Quizalofop-p-Ethyl Induces Adipogenesis in 3T3-L1 Adipocytes (2019).
- A Comparative Proteome Profile of Female Mouse Gonads Suggests a Tight Link between the Electron Transport Chain and Meiosis Initiation* (2018).
- Foxp3 drives oxidative phosphorylation and protection from lipotoxicity (2017).
- PreImplantation factor (PIF) therapy provides comprehensive protection against radiation induced pathologies (2016).
- Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease (2024).
- Simultaneous time course analysis of multiple markers based on DNA microarray in incised wound in skeletal muscle for wound aging (2016).
- Adipocyte-specific Steap4 deficiency reduced thermogenesis and energy expenditure in mice (2025).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
electron transport chain pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| O₂ | Metabolite | hmdb:HMDB0001377 | |
| H⁺ | Metabolite | chebi:15378 | |
| ATP | Metabolite | kegg.compound:C00002 | |
| Succinate | Metabolite | kegg.compound:C00042 | |
| e- | Metabolite | kegg.compound:C05359 | |
| FADH2 | Metabolite | kegg.compound:C01352 | |
| FAD | Metabolite | kegg.compound:C00016 | |
| NAD+ | Metabolite | kegg.compound:C00003 | |
| H₂O | Metabolite | hmdb:HMDB0002111 | |
| Cytochrome C | Metabolite | kegg.compound:C00524 | |
| NADH | Metabolite | kegg.compound:C00004 | |
| Ubiquinone | Metabolite | hmdb:HMDB0002012 | |
| Atp5a1 | GeneProduct | ensembl:ENSMUSG00000025428 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:498 |
| Ndufb6 | GeneProduct | ensembl:ENSMUSG00000071014 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4712 |
| Atp5k | GeneProduct | ensembl:ENSMUSG00000050856 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:521 |
| Slc25a5 | GeneProduct | ensembl:ENSMUSG00000016319 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:292 |
| Cox15 | GeneProduct | ensembl:ENSMUSG00000040018 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1355 |
| Cox6b1 | GeneProduct | ensembl:ENSMUSG00000036751 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1340 |
| Uqcr10 | GeneProduct | ensembl:ENSMUSG00000059534 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:29796 |
| Cox6c | GeneProduct | ensembl:ENSMUSG00000014313 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1345 |
| Atp5j2 | GeneProduct | ensembl:ENSMUSG00000038690 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9551 |
| Atp5o | GeneProduct | ensembl:ENSMUSG00000022956 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:539 |
| Atp5g2 | GeneProduct | ensembl:ENSMUSG00000062683 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:517 |
| Ndufc1 | GeneProduct | ensembl:ENSMUSG00000037152 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4717 |
| Atp5b | GeneProduct | ensembl:ENSMUSG00000025393 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:506 |
| Ndufa8 | GeneProduct | ensembl:ENSMUSG00000026895 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4702 |
| Uqcr11 | GeneProduct | ensembl:ENSMUSG00000020163 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10975 |
| Ndufa3 | GeneProduct | ensembl:ENSMUSG00000035674 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4696 |
| Slc25a14 | GeneProduct | ensembl:ENSMUSG00000031105 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9016 |
| Ndufv2 | GeneProduct | ensembl:ENSMUSG00000024099 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4729 |
| Ndufa6 | GeneProduct | ensembl:ENSMUSG00000022450 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4700 |
| mt-Co2 | GeneProduct | ensembl:ENSMUSG00000064354 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4513 |
| Ndufb9 | GeneProduct | ensembl:ENSMUSG00000022354 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4715 |
| Ndufs6 | GeneProduct | ensembl:ENSMUSG00000021606 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4726 |
| Uqcrfs1 | GeneProduct | ensembl:ENSMUSG00000038462 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7386 |
| Ndufa2 | GeneProduct | ensembl:ENSMUSG00000014294 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4695 |
| mt-Nd4l | GeneProduct | ensembl:ENSMUSG00000065947 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4539 |
| mt-Atp8 | GeneProduct | ensembl:ENSMUSG00000064356 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4509 |
| Ndufs5 | GeneProduct | ensembl:ENSMUSG00000028648 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4725 |
| Cox5a | GeneProduct | ensembl:ENSMUSG00000000088 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9377 |
| Uqcrc2 | GeneProduct | ensembl:ENSMUSG00000030884 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7385 |
| Atp5j | GeneProduct | ensembl:ENSMUSG00000022890 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:522 |
| Sdhb | GeneProduct | ensembl:ENSMUSG00000009863 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6390 |
| mt-Co1 | GeneProduct | ensembl:ENSMUSG00000064351 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4512 |
| Cox7a2l | GeneProduct | ensembl:ENSMUSG00000024248 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9167 |
| Ndufs7 | GeneProduct | ensembl:ENSMUSG00000020153 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:374291 |
| Cox6a1 | GeneProduct | ensembl:ENSMUSG00000041697 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1337 |
| Slc25a27 | GeneProduct | ensembl:ENSMUSG00000023912 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9481 |
| Ndufs4 | GeneProduct | ensembl:ENSMUSG00000021764 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4724 |
| Cox7a1 | GeneProduct | ensembl:ENSMUSG00000074218 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1346 |
| Cox4i1 | GeneProduct | ensembl:ENSMUSG00000031818 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1327 |
| Atp5l | GeneProduct | ensembl:ENSMUSG00000038717 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10632 |
| Ucp3 | GeneProduct | ensembl:ENSMUSG00000032942 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7352 |
| Uqcrh | GeneProduct | ensembl:ENSMUSG00000063882 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7388 |
| Ndufa9 | GeneProduct | ensembl:ENSMUSG00000000399 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4704 |
| Ndufb3 | GeneProduct | ensembl:ENSMUSG00000026032 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4709 |
| Ndufb4 | GeneProduct | ensembl:ENSMUSG00000022820 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4710 |
| Cox7a2 | GeneProduct | ensembl:ENSMUSG00000032330 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1347 |
| mt-Nd6 | GeneProduct | ensembl:ENSMUSG00000064368 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4541 |
| Atp5s | GeneProduct | ensembl:ENSMUSG00000054894 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:27109 |
| Sdha | GeneProduct | ensembl:ENSMUSG00000021577 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6389 |
| mt-Nd2 | GeneProduct | ensembl:ENSMUSG00000064345 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4536 |
| Ndufab1 | GeneProduct | ensembl:ENSMUSG00000030869 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4706 |
| Cox7b | GeneProduct | ensembl:ENSMUSG00000031231 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1349 |
| Uqcrq | GeneProduct | ensembl:ENSMUSG00000044894 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:27089 |
| Slc25a4 | GeneProduct | ensembl:ENSMUSG00000031633 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:291 |
| Uqcrb | GeneProduct | ensembl:ENSMUSG00000021520 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7381 |
| mt-Nd5 | GeneProduct | ensembl:ENSMUSG00000064367 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4540 |
| Ndufa12 | GeneProduct | ensembl:ENSMUSG00000020022 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:55967 |
| Sco1 | GeneProduct | ensembl:ENSMUSG00000069844 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6341 |
| Sdhd | GeneProduct | ensembl:ENSMUSG00000000171 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6392 |
| Atpif1 | GeneProduct | ensembl:ENSMUSG00000054428 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:93974 |
| Ndufb7 | GeneProduct | ensembl:ENSMUSG00000033938 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4713 |
| Ndufa1 | GeneProduct | ensembl:ENSMUSG00000016427 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4694 |
| Uqcrc1 | GeneProduct | ensembl:ENSMUSG00000025651 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7384 |
| Ndufb5 | GeneProduct | ensembl:ENSMUSG00000027673 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4711 |
| Cox5b | GeneProduct | ensembl:ENSMUSG00000061518 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1329 |
| mt-Atp6 | GeneProduct | ensembl:ENSMUSG00000064357 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4508 |
| mt-Co3 | GeneProduct | ensembl:ENSMUSG00000064358 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4514 |
| Ndufs3 | GeneProduct | ensembl:ENSMUSG00000005510 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4722 |
| Cox8a | GeneProduct | ensembl:ENSMUSG00000035885 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1351 |
| mt-Nd1 | GeneProduct | ensembl:ENSMUSG00000064341 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4535 |
| Ndufv1 | GeneProduct | ensembl:ENSMUSG00000037916 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4723 |
| Sdhc | GeneProduct | ensembl:ENSMUSG00000058076 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6391 |
| Atp5g3 | GeneProduct | ensembl:ENSMUSG00000018770 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:518 |
| Cox6a2 | GeneProduct | ensembl:ENSMUSG00000030785 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1339 |
| Surf1 | GeneProduct | ensembl:ENSMUSG00000015790 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6834 |
| Ndufs1 | GeneProduct | ensembl:ENSMUSG00000025968 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4719 |
| Ndufa7 | GeneProduct | ensembl:ENSMUSG00000041881 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4701 |
| mt-Nd4 | GeneProduct | ensembl:ENSMUSG00000064363 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4538 |
| Atp5h | GeneProduct | ensembl:ENSMUSG00000034566 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10476 |
| Ndufc2 | GeneProduct | ensembl:ENSMUSG00000030647 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4718 |
| Ndufb2 | GeneProduct | ensembl:ENSMUSG00000002416 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4708 |
| Ndufs2 | GeneProduct | ensembl:ENSMUSG00000013593 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4720 |
| Atp5d | GeneProduct | ensembl:ENSMUSG00000003072 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:513 |
| Ndufb10 | GeneProduct | ensembl:ENSMUSG00000040048 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4716 |
| Cox17 | GeneProduct | ensembl:ENSMUSG00000046516 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10063 |
| Ndufa4 | GeneProduct | ensembl:ENSMUSG00000029632 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4697 |
| Ndufa5 | GeneProduct | ensembl:ENSMUSG00000023089 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4698 |
| Atp5f1 | GeneProduct | ensembl:ENSMUSG00000000563 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:515 |
| Atp5e | GeneProduct | ensembl:ENSMUSG00000016252 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:514 |
| Atp5c1 | GeneProduct | ensembl:ENSMUSG00000025781 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:509 |
| Ndufv3 | GeneProduct | ensembl:ENSMUSG00000024038 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4731 |
| Ndufa10 | GeneProduct | ensembl:ENSMUSG00000026260 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4705 |
| Ucp2 | GeneProduct | ensembl:ENSMUSG00000033685 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7351 |
| mt-Nd3 | GeneProduct | ensembl:ENSMUSG00000064360 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4537 |
| Ndufs8 | GeneProduct | ensembl:ENSMUSG00000059734 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4728 |
| Gm20538 | GeneProduct | ensembl:ENSMUSG00000091471 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4714 |
| mt-Cytb | GeneProduct | ensembl:ENSMUSG00000064370 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4519 |
| Ucp1 | GeneProduct | ensembl:ENSMUSG00000031710 | Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7350 |