p53 signaling (WP2902)

Mus musculus

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http://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.

Authors

Linda Rieswijk , Egon Willighagen , Jonathan Mélius , and Friederike Ehrhart

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

p53 signaling pathway

Participants

Label Type Compact URI Comment
Atm GeneProduct ncbigene:11920
Chek2 GeneProduct ncbigene:50883
Atr GeneProduct ncbigene:245000
Chek1 GeneProduct ncbigene:12649
Cdkn2a GeneProduct ncbigene:12578
Mdm2 GeneProduct ncbigene:17246
Mdm4 GeneProduct ncbigene:17248
Trp53 GeneProduct ncbigene:22059
Cdkn1a GeneProduct ncbigene:12575
Ccnd1 GeneProduct ncbigene:12443
Ccnd2 GeneProduct ncbigene:12444
Ccnd3 GeneProduct ncbigene:12445
Cdk4 GeneProduct ncbigene:12567
Cdk6 GeneProduct ncbigene:12571
Ccne1 GeneProduct ncbigene:12447
Ccne2 GeneProduct ncbigene:12448
Cdk2 GeneProduct ncbigene:12566
Sfn GeneProduct ncbigene:55948
Rprm GeneProduct ncbigene:67874
Ccnb1 GeneProduct ncbigene:268697
Ccnb2 GeneProduct ncbigene:12442
Ccnb3 GeneProduct ncbigene:209091
Gm5593 GeneProduct ensembl:ENSMUSG00000048574
Cdk1 GeneProduct ncbigene:12534
Gadd45a GeneProduct ncbigene:13197
Gadd45b GeneProduct ncbigene:17873
Gadd45g GeneProduct ncbigene:23882
Gtse1 GeneProduct ncbigene:29870
Fas GeneProduct ncbigene:14102
Pidd1 GeneProduct ncbigene:57913
Casp8 GeneProduct ncbigene:12370
Bid GeneProduct ncbigene:12122
Bax GeneProduct ncbigene:12028
Pmaip1 GeneProduct ncbigene:58801
Bbc3 GeneProduct ncbigene:170770
Ei24 GeneProduct ncbigene:13663
Shisa5 GeneProduct ncbigene:66940
Perp GeneProduct ncbigene:64058
Zmat3 GeneProduct ncbigene:22401
Siah1a GeneProduct ncbigene:20437
Siah1b GeneProduct ncbigene:20438
Cycs GeneProduct ncbigene:13063
Cyct GeneProduct ncbigene:13067
Apaf1 GeneProduct ncbigene:11783
Casp9 GeneProduct ncbigene:12371
Casp3 GeneProduct ncbigene:12367
Igfbp3 GeneProduct ncbigene:16009
Igf1 GeneProduct ncbigene:16000
Serpine1 GeneProduct ncbigene:18787
Bai1 GeneProduct ncbigene:107831
Cd82 GeneProduct ncbigene:12521
Thbs1 GeneProduct ncbigene:21825
Serpinb5 GeneProduct ncbigene:20724
Ddb2 GeneProduct ncbigene:107986
Rrm2b GeneProduct ncbigene:382985
Rrm2 GeneProduct ncbigene:20135
Sesn1 GeneProduct ncbigene:140742
Sesn2 GeneProduct ncbigene:230784
Sesn3 GeneProduct ncbigene:75747
Pten GeneProduct ncbigene:19211
Tsc2 GeneProduct ncbigene:22084
Steap3 GeneProduct ncbigene:68428
Rfwd2 GeneProduct ncbigene:26374
Rchy1 GeneProduct ncbigene:68098
Ccng1 GeneProduct ncbigene:12450
Ccng2 GeneProduct ncbigene:12452
Ppm1d GeneProduct ncbigene:53892
Trp73 GeneProduct ncbigene:22062
mmu-miR-425-5p GeneProduct mirbase.mature:mmu-miR-425-5p
mmu-miR-29b-3p GeneProduct mirbase.mature:mmu-miR-29b-3p
mmu-miR-16-5p GeneProduct mirbase.mature:mmu-miR-16-5p
mmu-miR-291a-3p GeneProduct mirbase.mature:mmu-miR-291a-3p
mmu-miR-291b-3p GeneProduct mirbase.mature:mmu-miR-291b-3p
mmu-miR-294-3p GeneProduct mirbase.mature:mmu-miR-294-3p
mmu-miR-295-3p GeneProduct mirbase.mature:mmu-miR-295-3p
mmu-miR-302d-3p GeneProduct mirbase.mature:mmu-miR-302d-3p
mmu-miR-18a-5p GeneProduct mirbase.mature:mmu-miR-18a-5p
mmu-miR-20a-5p GeneProduct mirbase.mature:mmu-miR-20a-5p
mmu-miR-503-5p GeneProduct mirbase.mature:mmu-miR-503-5p
mmu-miR-181b-5p GeneProduct mirbase.mature:mmu-miR-181b-5p
mmu-miR-223-3p GeneProduct mirbase.mature:mmu-miR-223-3p
mmu-miR-122-5p GeneProduct mirbase.mature:mmu-miR-122-5p
mmu-miR-216a-5p GeneProduct mirbase.mature:mmu-miR-216a-5p
mmu-miR-217-5p GeneProduct mirbase.mature:mmu-miR-217-5p
mmu-miR-195a-5p GeneProduct mirbase.mature:mmu-miR-195a-5p
mmu-miR-103a-3p GeneProduct mirbase.mature:mmu-miR-103a-3p
mmu-miR-486-5p GeneProduct mirbase.mature:mmu-miR-486-5p
mmu-miR-21-5p GeneProduct mirbase.mature:mmu-miR-21-5p
mmu-miR-34b-5p GeneProduct mirbase.mature:mmu-miR-34b-5p
mmu-miR-15a-5p GeneProduct mirbase.mature:mmu-miR-15a-5p
mmu-miR-1a-3p GeneProduct mirbase.mature:mmu-miR-1a-3p
mmu-miR-301b-3p GeneProduct mirbase.mature:mmu-miR-301b-3p
mmu-miR-9-5p GeneProduct mirbase.mature:mmu-miR-9-5p
mmu-miR-7b-5p GeneProduct mirbase.mature:mmu-miR-7b-5p
mmu-miR-24-3p GeneProduct mirbase.mature:mmu-miR-24-3p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-758-3p GeneProduct mirbase.mature:mmu-miR-758-3p
mmu-miR-145a-5p GeneProduct mirbase.mature:mmu-miR-145a-5p
mmu-miR-449a-5p GeneProduct mirbase.mature:mmu-miR-449a-5p
mmu-let-7b-5p GeneProduct mirbase.mature:mmu-let-7b-5p
mmu-miR-362-5p GeneProduct mirbase.mature:mmu-miR-362-5p
mmu-miR-17-5p GeneProduct mirbase.mature:mmu-miR-17-5p
mmu-miR-181a-5p GeneProduct mirbase.mature:mmu-miR-181a-5p
mmu-miR-297a-5p GeneProduct mirbase.mature:mmu-miR-297a-5p
mmu-miR-340-5p GeneProduct mirbase.mature:mmu-miR-340-5p
mmu-miR-21a-5p GeneProduct mirbase.mature:mmu-miR-21a-5p
mmu-miR-149-5p GeneProduct mirbase.mature:mmu-miR-149-5p
mmu-miR-124-3p GeneProduct mirbase.mature:mmu-miR-124-3p
mmu-miR-30e-5p GeneProduct mirbase.mature:mmu-miR-30e-5p
Gadd45g GeneProduct ncbigene:23882
Gadd45b GeneProduct ncbigene:17873
Gadd45a GeneProduct ncbigene:13197
Igfbp3 GeneProduct ncbigene:16009
Mdm2 GeneProduct ncbigene:17246
Siah1a GeneProduct ncbigene:20437
Siah1b GeneProduct ncbigene:20438
mmu-miR-425-5p GeneProduct mirbase.mature:mmu-miR-425-5p
mmu-miR-16-5p GeneProduct mirbase.mature:mmu-miR-16-5p
mmu-miR-17-5p GeneProduct mirbase.mature:mmu-miR-17-5p
mmu-miR-301b-3p GeneProduct mirbase.mature:mmu-miR-301b-3p
mmu-miR-301b-3p GeneProduct mirbase.mature:mmu-miR-301b-3p
mmu-miR-301b-3p GeneProduct mirbase.mature:mmu-miR-301b-3p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-503-5p GeneProduct mirbase.mature:mmu-miR-503-5p
mmu-let-7b-5p GeneProduct mirbase.mature:mmu-let-7b-5p
mmu-miR-19b-3p GeneProduct mirbase.mature:mmu-miR-19b-3p
mmu-miR-340-5p GeneProduct mirbase.mature:mmu-miR-340-5p
mmu-miR-34b-5p GeneProduct mirbase.mature:mmu-miR-34b-5p
mmu-miR-149-5p GeneProduct mirbase.mature:mmu-miR-149-5p
mmu-miR-362-5p GeneProduct mirbase.mature:mmu-miR-362-5p
mmu-miR-15a-5p GeneProduct mirbase.mature:mmu-miR-15a-5p
mmu-miR-362-5p GeneProduct mirbase.mature:mmu-miR-362-5p
mmu-miR-15a-5p GeneProduct mirbase.mature:mmu-miR-15a-5p
mmu-miR-15a-5p GeneProduct mirbase.mature:mmu-miR-15a-5p
mmu-miR-24-3p GeneProduct mirbase.mature:mmu-miR-24-3p

References

  1. Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes. Rieswijk L, Brauers KJJ, Coonen MLJ, van Breda SGJ, Jennen DGJ, Kleinjans JCS. Mutagenesis. 2015 Nov;30(6):771–84. PubMed Europe PMC Scholia