White fat cell differentiation (WP2872)

Mus musculus

The transcription factors involved in white fat cell differentiation are shown, specifically their pattern of activity from the preadipocyte to the adipocyte (fat cells) stage. Adipose tissue, composed of white and brown adipose tissue, is composed of adipocytes. This pathway is primarily studied to understand factors that contribute to obesity and diabetes. Transcriptional and hormonal regulators of adipocyte formation are indicated.


Petra Schwalie , Egon Willighagen , Bart Smeets , Marianthi Kalafati , and Kristina Hanspers


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Mus musculus



Cell Type Ontology

white fat cell

Pathway Ontology

signaling pathway


Label Type Compact URI Comment
cAMP Metabolite chebi:17489
Glucocorticoids Metabolite chebi:24261
Wnt10b GeneProduct ncbigene:22410
Ebf1 GeneProduct ncbigene:13591
Srebf1 GeneProduct ncbigene:20787
Cebpa GeneProduct ncbigene:12606
Cebpb GeneProduct ncbigene:12608
Evi1 GeneProduct ncbigene:14013
Rora GeneProduct ncbigene:19883
Ddit3 (CHOP) GeneProduct ncbigene:13198
Creb1 GeneProduct ncbigene:12912
Irf3 GeneProduct ncbigene:54131
Stat5b GeneProduct ncbigene:20851
Klf15 GeneProduct ncbigene:66277
Klf5 GeneProduct ncbigene:12224
Gata2 GeneProduct ncbigene:14461
Tcf7l1 GeneProduct ncbigene:21415
Zfp423 GeneProduct ncbigene:94187
Egr2 (Krox20) GeneProduct ncbigene:13654
Gata3 GeneProduct ncbigene:14462
Nr2f2 GeneProduct ncbigene:11819
Pparg GeneProduct ncbigene:19016
Lxr (Nr1h3) GeneProduct ncbigene:22259
Cebpd GeneProduct ncbigene:12609
catenin (Ctnna1) GeneProduct ncbigene:12385
Klf4 GeneProduct ncbigene:16600
Rara GeneProduct ncbigene:19401
Foxo1 GeneProduct ncbigene:56458
Stat5a GeneProduct ncbigene:20850
Tle3 GeneProduct ncbigene:21887
Ins1 GeneProduct ncbigene:16333
Nr3c1 (GR) GeneProduct ncbigene:14815
Irf4 GeneProduct ncbigene:16364
Klf2 GeneProduct ncbigene:16598


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  2. Adipocyte differentiation from the inside out. Rosen ED, MacDougald OA. Nat Rev Mol Cell Biol. 2006 Dec;7(12):885–96. PubMed Europe PMC Scholia
  3. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, et al. Cell Metab. 2011 Apr 6;13(4):413–27. PubMed Europe PMC Scholia
  4. Transcriptional networks and chromatin remodeling controlling adipogenesis. Siersbæk R, Nielsen R, Mandrup S. Trends Endocrinol Metab. 2012 Feb;23(2):56–64. PubMed Europe PMC Scholia
  5. Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network. Gubelmann C, Schwalie PC, Raghav SK, Röder E, Delessa T, Kiehlmann E, et al. Elife. 2014 Aug 27;3:e03346. PubMed Europe PMC Scholia