Ethylene signaling pathway (WP2851)

Arabidopsis thaliana

Ethylene signal transduction and the control of juvenile to adult phase transitions in the leaf. The pathway for ethylene signal transduction involves positive and negative regulators that culminate in transcriptional regulation by the EIN3-like family of transcription factors. Among the ethylene-responsive genes are some that encode additional transcription factors such as those of the ethylene response factor (ERF) and ethylene response DNA-binding factor (EDF) families. The pharmacological agents aminoethoxyvinylglycine (AVG) and silver can be used to inhibit ethylene responses through their ability to target ethylene biosynthesis or the receptors, respectively. One effect of ethylene is to stimulate the juvenile to adult phase transition of leaves. The transcription factor FUS3 negatively regulates the effects of ethylene on this developmental process.


Martina Summer-Kutmon , Susan Coort , and Denise Slenter


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Arabidopsis thaliana



Pathway Ontology

signaling pathway


Label Type Compact URI Comment
C2H4 Metabolite chebi:18153
AVG Metabolite pubchem.compound:6436272
Silver Metabolite chebi:49468
EIN4 GeneProduct ensembl:AT3G04580
EIN2 GeneProduct ensembl:AT5G03280
ETR2 GeneProduct ensembl:AT3G23150
ERS2 GeneProduct ensembl:AT1G04310
FUS3 GeneProduct ensembl:AT3G26790
ERS1 GeneProduct ensembl:AT2G40940
CTR1 GeneProduct ensembl:AT5G03730
ETR1 GeneProduct ensembl:AT1G66340


  1. The ethylene-receptor family from Arabidopsis: structure and function. Bleecker AB, Esch JJ, Hall AE, Rodríguez FI, Binder BM. Philos Trans R Soc Lond B Biol Sci. 1998 Sep 29;353(1374):1405–12. PubMed Europe PMC Scholia
  2. Ethylene and the regulation of plant development. Schaller GE. BMC Biol. 2012 Feb 20;10:9. PubMed Europe PMC Scholia