Monoamine GPCRs (WP276)
Rattus norvegicus
G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [https://en.wikipedia.org/wiki/G_protein–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [https://en.wikipedia.org/wiki/Monoamine_neurotransmitter Monoamine neurotransmitters]
Authors
Nathan Salomonis , Joanna S. Fong , Egon Willighagen , Daniela Digles , and Kristina HanspersActivity
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Organisms
Rattus norvegicusCommunities
Annotations
Pathway Ontology
G protein mediated signaling pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
Serotonin | Metabolite | chebi:28790 | |
Epinephrine | Metabolite | hmdb:HMDB0000068 | |
Norepinephrine | Metabolite | hmdb:HMDB0000216 | |
Acetylcholine | Metabolite | hmdb:HMDB0000895 | |
Muscarine | Metabolite | pubchem.compound:9308 | |
Histamine | Metabolite | chebi:18295 | |
Dopamine | Metabolite | chebi:18243 | |
Hrh1 | GeneProduct | ncbigene:24448 | |
Adra2c | GeneProduct | ncbigene:24175 | |
Htr4 | GeneProduct | ncbigene:25324 | |
Drd3 | GeneProduct | ncbigene:29238 | |
Hrh2 | GeneProduct | ncbigene:25461 | |
Chrm3 | GeneProduct | ncbigene:24260 | |
Adra1a | GeneProduct | ncbigene:29412 | |
Drd5 | GeneProduct | ncbigene:25195 | |
HTR5B | GeneProduct | ncbigene:79247 | |
Drd4 | GeneProduct | ncbigene:25432 | |
Adrb3 | GeneProduct | ncbigene:25645 | |
Adra1b | GeneProduct | ncbigene:24173 | |
Chrm2 | GeneProduct | ncbigene:81645 | |
Htr6 | GeneProduct | ncbigene:64354 | |
Htr1d | GeneProduct | ncbigene:25323 | |
Chrm1 | GeneProduct | ncbigene:25229 | |
Htr7 | GeneProduct | ncbigene:65032 | |
Chrm4 | GeneProduct | ncbigene:25111 | |
Drd2 | GeneProduct | ncbigene:24318 | |
Chrm5 | GeneProduct | ncbigene:53949 | |
ADRA2A | GeneProduct | ncbigene:25083 | |
Htr2a | GeneProduct | ncbigene:29595 | |
Htr1f | GeneProduct | ncbigene:60448 | |
Drd1a | GeneProduct | ncbigene:24316 | |
Htr5a | GeneProduct | ncbigene:25689 | |
Adrb1 | GeneProduct | ncbigene:24925 | |
Adra2b | GeneProduct | ncbigene:24174 | |
Htr2c | GeneProduct | ncbigene:25187 | |
Htr2b | GeneProduct | ncbigene:29581 | |
Htr1a | GeneProduct | ncbigene:24473 | |
Adra1d | GeneProduct | ncbigene:29413 | |
Htr1b | GeneProduct | ncbigene:25075 | |
Adrb2 | GeneProduct | ncbigene:24176 |