Monoamine GPCRs (WP276)

Rattus norvegicus

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] Monoamine GPCRs are Rhodopsin-like GPCRs that bind to monoamine neurotransmitters. [ Monoamine neurotransmitters]


Nathan Salomonis , Joanna S. Fong , Egon Willighagen , Daniela Digles , and Kristina Hanspers


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Rattus norvegicus



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
Serotonin Metabolite chebi:28790
Epinephrine Metabolite hmdb:HMDB0000068
Norepinephrine Metabolite hmdb:HMDB0000216
Acetylcholine Metabolite hmdb:HMDB0000895
Muscarine Metabolite pubchem.compound:9308
Histamine Metabolite chebi:18295
Dopamine Metabolite chebi:18243
Hrh1 GeneProduct ncbigene:24448
Adra2c GeneProduct ncbigene:24175
Htr4 GeneProduct ncbigene:25324
Drd3 GeneProduct ncbigene:29238
Hrh2 GeneProduct ncbigene:25461
Chrm3 GeneProduct ncbigene:24260
Adra1a GeneProduct ncbigene:29412
Drd5 GeneProduct ncbigene:25195
HTR5B GeneProduct ncbigene:79247
Drd4 GeneProduct ncbigene:25432
Adrb3 GeneProduct ncbigene:25645
Adra1b GeneProduct ncbigene:24173
Chrm2 GeneProduct ncbigene:81645
Htr6 GeneProduct ncbigene:64354
Htr1d GeneProduct ncbigene:25323
Chrm1 GeneProduct ncbigene:25229
Htr7 GeneProduct ncbigene:65032
Chrm4 GeneProduct ncbigene:25111
Drd2 GeneProduct ncbigene:24318
Chrm5 GeneProduct ncbigene:53949
ADRA2A GeneProduct ncbigene:25083
Htr2a GeneProduct ncbigene:29595
Htr1f GeneProduct ncbigene:60448
Drd1a GeneProduct ncbigene:24316
Htr5a GeneProduct ncbigene:25689
Adrb1 GeneProduct ncbigene:24925
Adra2b GeneProduct ncbigene:24174
Htr2c GeneProduct ncbigene:25187
Htr2b GeneProduct ncbigene:29581
Htr1a GeneProduct ncbigene:24473
Adra1d GeneProduct ncbigene:29413
Htr1b GeneProduct ncbigene:25075
Adrb2 GeneProduct ncbigene:24176