Heroin metabolism (WP2645)

Homo sapiens

Pathway complementing the morphine metabolism pathway around heroin. The catalytic efficiency is substantially greater for CES2 (a.k.a. hCE-2) compared to other esterases.

Authors

Egon Willighagen and Denise Slenter

Activity

last edited

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

xenobiotic metabolic pathway drug pathway heroin drug pathway

Participants

Label Type Compact Identifier Comment
morphine Metabolite chebi:17303
heroin Metabolite chebi:27808
6-acetylmorphine Metabolite pubchem.compound:5462507 6-monoacetylmorphine
CES1 GeneProduct ensembl:ENSG00000198848 catalyzed in liver
CES2 GeneProduct ensembl:ENSG00000172831 catalyzed in liver; catalytic efficiency is substantially greater for hCE-2 compared to other esterases.
CES2 GeneProduct ensembl:ENSG00000172831 catalyzed in liver; catalytic efficiency is substantially greater for hCE-2 compared to other esterases.
Pseudo-ChE Protein ensembl:ENSG00000114200 pseudocholinesterase; catalysation takes place in serum
Pseudo-ChE Protein ensembl:ENSG00000114200 pseudocholinesterase

References

  1. The therapeutic use of heroin: a review of the pharmacological literature. Sawynok J. Can J Physiol Pharmacol. 1986 Jan;64(1):1–6. PubMed Europe PMC Scholia
  2. Human carboxylesterase 1: from drug metabolism to drug discovery. Redinbo MR, Bencharit S, Potter PM. Biochem Soc Trans. 2003 Jun;31(Pt 3):620–4. PubMed Europe PMC Scholia
  3. Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine. Maurer HH, Sauer C, Theobald DS. Ther Drug Monit. 2006 Jun;28(3):447–53. PubMed Europe PMC Scholia
  4. Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin. Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, et al. Br J Pharmacol. 2010 Aug;160(8):1916–28. PubMed Europe PMC Scholia