Pto kinase mediated signaling pathway leading to the oxidative burst in tomato (WP2633)

Solanum lycopersicum

Hypothetical model showing the integration of the Pto kinase with other known signaling intermediates in the oxidative burst signal transduction pathways. See text for details and references. Plase A, phospholipase A; Plase C, phospholipase C; oxidase subunits include p47, p67, gp91, and p22.


Andra Waagmeester and Linda Rieswijk


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Solanum lycopersicum



Pathway Ontology

signaling pathway


Label Type Compact URI Comment
Oxygen Metabolite chemspider:952
Superoxide Metabolite chemspider:4514331
Hydrogen peroxide Metabolite chemspider:763
NADPH Metabolite chemspider:5673
NADP+ Metabolite chemspider:5674
Fenthion Metabolite chemspider:3229
Gp91 GeneProduct ensembl:Solyc03g117980.2
Pto GeneProduct ensembl:Solyc05g013320.1
Pti1 GeneProduct ensembl:Solyc12g098980.1
Fen GeneProduct ensembl:Solyc05g013290.1
AvrPto GeneProduct uniprot:Q08242
Kinases GeneProduct eccode:2.7.1.-.


  1. Evidence for participation of GTP-binding proteins in elicitation of the rapid oxidative burst in cultured soybean cells. Legendre L, Heinstein PF, Low PS. J Biol Chem. 1992 Oct 5;267(28):20140–7. PubMed Europe PMC Scholia
  2. New method for quantitative determination of uronic acids. Blumenkrantz N, Asboe-Hansen G. Anal Biochem. 1973 Aug;54(2):484–9. PubMed Europe PMC Scholia
  3. The disease-resistance gene Pto and the fenthion-sensitivity gene fen encode closely related functional protein kinases. Loh YT, Martin GB. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4181–4. PubMed Europe PMC Scholia
  4. A member of the tomato Pto gene family confers sensitivity to fenthion resulting in rapid cell death. Martin GB, Frary A, Wu T, Brommonschenkel S, Chunwongse J, Earle ED, et al. Plant Cell. 1994 Nov;6(11):1543–52. PubMed Europe PMC Scholia
  5. Map-based cloning of a protein kinase gene conferring disease resistance in tomato. Martin GB, Brommonschenkel SH, Chunwongse J, Frary A, Ganal MW, Spivey R, et al. Science. 1993 Nov 26;262(5138):1432–6. PubMed Europe PMC Scholia
  6. Plant disease resistance genes in signal perception and transduction. Lamb CJ. Cell. 1994 Feb 11;76(3):419–22. PubMed Europe PMC Scholia
  7. The tomato gene Pti1 encodes a serine/threonine kinase that is phosphorylated by Pto and is involved in the hypersensitive response. Zhou J, Loh YT, Bressan RA, Martin GB. Cell. 1995 Dec 15;83(6):925–35. PubMed Europe PMC Scholia
  8. Plant and human neutrophil oxidative burst complexes contain immunologically related proteins. Dwyer SC, Legendre L, Low PS, Leto TL. Biochim Biophys Acta. 1996 Mar 15;1289(2):231–7. PubMed Europe PMC Scholia
  9. Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase. Yu L, Quinn MT, Cross AR, Dinauer MC. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7993–8. PubMed Europe PMC Scholia
  10. The Pto kinase mediates a signaling pathway leading to the oxidative burst in tomato. Chandra S, Martin GB, Low PS. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13393–7. PubMed Europe PMC Scholia
  11. Characterization of the Oligogalacturonide-Induced Oxidative Burst in Cultured Soybean (Glycine max) Cells. Legendre L, Rueter S, Heinstein PF, Low PS. Plant Physiol. 1993 May;102(1):233–40. PubMed Europe PMC Scholia
  12. Regulation of NADPH oxidase subunit p22(phox) by NF-kB in human aortic smooth muscle cells. Manea A, Manea SA, Gafencu AV, Raicu M. Arch Physiol Biochem. 2007;113(4–5):163–72. PubMed Europe PMC Scholia