Glucose-1-phosphate metabolism (WP260)

Saccharomyces cerevisiae

Glycogen, a branched polymer of glucose, is a storage molecule whose accumulation is under rigorous control in many cells. In Saccharomyces cerevisiae, glycogen biosynthesis involves three processes: nucleation, elongation, and branching (also known as ramification). The formation of glycogen begins when either Glg1p or Glg2p uses UDP-glucose to self-glucosylate to produce a short alpha (1,4)-glucosyl chain covalently attached to one of their internal tyrosine residues. After the self-glucosylation of Glg1p or Glg2p, glycogen synthase is able to extend the linear alpha (1,4)-glucosyl chains of glycogen by catalyzing the formation of alpha (1,4)-glucosidic bonds from UDP- glucose at the non-reducing ends. Branches can be added into the glycogen molecule by Glc3p, which is the glycogen branching enzyme (EC: in S. cerevisiae.


Jessica Heckman , Christine Chichester , Egon Willighagen , Denise Slenter , and Martina Summer-Kutmon


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Saccharomyces cerevisiae



Pathway Ontology

glycogen biosynthetic pathway glucose utilization pathway glucose conversion pathway


Label Type Compact URI Comment
UTP Metabolite chebi:46398
UDP-D-glucose Metabolite chebi:46229
H2O Metabolite chebi:15377
NADP Metabolite chebi:44409
beta-D-Glucose Metabolite chebi:15903
delta-Glucono-delta-lactone Metabolite chebi:16217
glucose-1-phosphate Metabolite chebi:16077
Glycogen Metabolite chebi:28087
pyrophosphate Metabolite cas:2466-09-3
(1,4-alpha-D-glucosyl)n - R Metabolite chebi:15444 R = a glycogenin
fructose Metabolite cas:7776-48-9
glucose-6-phosphate Metabolite chebi:75150
UDP Metabolite chebi:17659
UDP-D-glucose Metabolite chebi:46229
NADPH Metabolite cas:53-57-6
phosphate Metabolite cas:14265-44-2
(1,4-alpha-D-Glucosyl)n+1 - R Metabolite chebi:28102 R = a glycogenin
UDP-D-glucose Metabolite chebi:46229
UDP Metabolite chebi:17659
UDP-D-glucose Metabolite chebi:46229
UDP Metabolite chebi:17659
YHL012W GeneProduct sgd:S000001004
PGM1 GeneProduct sgd:S000001610
GSY2 GeneProduct ensembl:YLR258W
UGP1 GeneProduct sgd:S000001518
GSY1 GeneProduct ensembl:YFR015C
PGM2 GeneProduct sgd:S000004711
GLC3 GeneProduct ensembl:YEL011W


  1. Coordinate regulation of glycogen metabolism in the yeast Saccharomyces cerevisiae. Induction of glycogen branching enzyme. Thon VJ, Vigneron-Lesens C, Marianne-Pepin T, Montreuil J, Decq A, Rachez C, et al. J Biol Chem. 1992 Jul 25;267(21):15224–8. PubMed Europe PMC Scholia
  2. Two glycogen synthase isoforms in Saccharomyces cerevisiae are coded by distinct genes that are differentially controlled. Farkas I, Hardy TA, Goebl MG, Roach PJ. J Biol Chem. 1991 Aug 25;266(24):15602–7. PubMed Europe PMC Scholia
  3. Initiation of glycogen synthesis in yeast. Requirement of multiple tyrosine residues for function of the self-glucosylating Glg proteins in vivo. Mu J, Cheng C, Roach PJ. J Biol Chem. 1996 Oct 25;271(43):26554–60. PubMed Europe PMC Scholia
  4. Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae. François J, Parrou JL. FEMS Microbiol Rev. 2001 Jan;25(1):125–45. PubMed Europe PMC Scholia