Secretion of hydrochloric acid in parietal cells (WP2597)

Homo sapiens

Gastric parietal cells are stomach epithelial cells. They secrete gastric acid and intrinsic factor. This pathway is primarily based on https://en.wikipedia.org/wiki/Parietal_cell

Authors

Andra Waagmeester , Martina Summer-Kutmon , Linda Rieswijk , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

acid-base homeostasis pathway

Cell Type Ontology

parietal cell

Participants

Label Type Compact URI Comment
Chloride ion Metabolite hmdb:HMDB0000492
Acetylcholine Metabolite chemspider:182
Potassium Metabolite hmdb:HMDB0000586
Histamine Metabolite chemspider:753
Carbon dioxide Metabolite chemspider:274
Water Metabolite chemspider:937
Bicarbonate ion Metabolite chemspider:749
Zinc Metabolite chemspider:22430
Hydrogen Metabolite hmdb:HMDB0059597
Bicarbonate ion Metabolite chemspider:749
Hydrogen Metabolite hmdb:HMDB0059597
Chloride ion Metabolite hmdb:HMDB0000492
Potassium Metabolite hmdb:HMDB0000586
Chloride ion Metabolite hmdb:HMDB0000492
Gastrin GeneProduct uniprot:P01350
ATP4A GeneProduct ncbigene:495
HRH2 GeneProduct ncbigene:3274
CHRM1 GeneProduct ncbigene:1128
CCKBR GeneProduct ncbigene:887

References

  1. Purification and characterization of human salivary carbonic anhydrase. Murakami H, Sly WS. J Biol Chem. 1987 Jan 25;262(3):1382–8. PubMed Europe PMC Scholia