RTK/Ras/MAPK - LET-23, EGL-15 independent (WP2569)
This pathway represents the core elements of Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) pathways. Many developmental events in C. elegans require this signaling pathway with different RTK's providing activation of the pathway in specific cell-types and under different regulatory controls. Depending on the process, this signaling pathway may interact with the Wnt, Notch, or other pathways during development.
AuthorsKaren Yook and Egon Willighagen
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Pathway OntologyRas mediated signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway
- RTK/Ras/MAPK signaling. Sundaram MV. WormBook. 2006 Feb 11;1–19. PubMed Europe PMC Scholia