Glyoxylate cycle (WP2566)

Mycobacterium tuberculosis

The glyoxylate cycle transforms acetyl-CoA derived from the β-oxidation of fatty acids into oxaloacetate, an intermediate of the citric acid cycle


Andra Waagmeester , Martina Summer-Kutmon , Kristina Hanspers , and Friederike Ehrhart


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Mycobacterium tuberculosis



Pathway Ontology

glyoxylate and dicarboxylate metabolic pathway


Label Type Compact URI Comment
Fumarate Metabolite chemspider:4573886
Glyoxylate Metabolite chemspider:2849615
Acetyl-CoA Metabolite chemspider:392413
Malate Metabolite chemspider:140981
Citrate Metabolite chemspider:29081
Oxaloacetate Metabolite chemspider:2509917
Succinate Metabolite chemspider:140973
Isocitrate Metabolite chemspider:4573809
Acetyl-CoA Metabolite chemspider:392413
MLS GeneProduct uniprot:P9WK16
SDHA GeneProduct uniprot:L7N501
CITA GeneProduct uniprot:P63777
CITE GeneProduct uniprot:O06162
ICL1 GeneProduct uniprot:P0A5H3
ICL2b GeneProduct uniprot:L0T891
MQO GeneProduct uniprot:P65419
ICL2a GeneProduct uniprot:L0T829
MDH GeneProduct uniprot:P0A5J6
ACN GeneProduct uniprot:L7N4I7
FUM GeneProduct uniprot:O53446
SDHB GeneProduct uniprot:L7N605
SDHC GeneProduct uniprot:L7N510
SDHD GeneProduct uniprot:L0TC66
ACN GeneProduct uniprot:L7N4I7


  1. Isociatrate lyase in mycobacteria. Seshadri R, Murthy PS, Venkitasubramanian TA. Indian J Biochem Biophys. 1976 Mar;13(1):95–6. PubMed Europe PMC Scholia
  2. Use of carbon sources for lipid biosynthesis in Mycobacterium leprae: a comparison with other pathogenic mycobacteria. Wheeler PR, Ratledge C. J Gen Microbiol. 1988 Aug;134(8):2111–21. PubMed Europe PMC Scholia
  3. Metabolic studies on mycobacteria. IV. Assay of isocitrate lyase and malate synthase activity in M. leprae. Bharadwaj VP, Katoch VM, Sharma VD, Kannan KB, Datta AK, Shivannavar CT. Indian J Lepr. 1987;59(2):158–62. PubMed Europe PMC Scholia
  4. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, et al. Nature. 2000 Aug 17;406(6797):735–8. PubMed Europe PMC Scholia
  5. Synthesis of cell constituents from C2-units by a modified tricarboxylic acid cycle. KORNBERG HL, KREBS HA. Nature. 1957 May 18;179(4568):988–91. PubMed Europe PMC Scholia
  6. Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence. Muñoz-Elías EJ, McKinney JD. Nat Med. 2005 Jun;11(6):638–44. PubMed Europe PMC Scholia
  7. Role of the methylcitrate cycle in Mycobacterium tuberculosis metabolism, intracellular growth, and virulence. Muñoz-Elías EJ, Upton AM, Cherian J, McKinney JD. Mol Microbiol. 2006 Jun;60(5):1109–22. PubMed Europe PMC Scholia