Glycolysis (WP253)
Saccharomyces cerevisiae
Glycolysis, which was first studied as a pathway for the utilization of glucose, is one of the major pathways of central metabolism, the other two being the pentose phosphate pathway and the TCA cycle. Glycolysis is essential under all conditions of growth, because it produces six of the 13 precursor metabolites that are the starting materials for the biosynthesis of building blocks for macromolecules and other needed small molecules (the six compounds are β-D-glucose 6-phosphate, β-D-fructofuranose 6-phosphate, glycerone phosphate, 3-phospho-D-glycerate, phosphoenolpyruvate, and pyruvate). Glycolysis can be found, if at least in part, in almost all organisms. Source: https://pathway.yeastgenome.org/
Authors
Jessica Heckman , Christine Chichester , Egon Willighagen , Denise Slenter , Marvin Martens , and Kristina HanspersActivity
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Organisms
Saccharomyces cerevisiaeCommunities
Annotations
Pathway Ontology
glycolysis pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| H+ | Metabolite | chebi:15378 | |
| dihydroxy-acetone-phosphate | Metabolite | hmdb:HMDB0001473 | |
| fructose-1,6-bisphosphate | Metabolite | hmdb:HMDB0001058 | |
| 2-phosphoglycerate | Metabolite | chebi:24344 | |
| H2O | Metabolite | chebi:15377 | |
| pyruvate | Metabolite | chebi:15361 | |
| NAD | Metabolite | chebi:13389 | |
| 3-Phosphoglycerate | Metabolite | chebi:17050 | |
| fructose-6-phosphate (closed form) | Metabolite | chemspider:26330295 | |
| glyceraldehyde-3-phosphate | Metabolite | cas:591-57-1 | |
| NADH | Metabolite | cas:53-84-9 | |
| ADP | Metabolite | cas:58-64-0 | |
| ATP | Metabolite | cas:1927-31-7 | |
| glucose-6-phosphate (closed form) | Metabolite | chebi:75150 | |
| 3-phospho-D-glyceroyl-phosphate | Metabolite | cas:38168-82-0 | |
| phosphoenolpyruvate | Metabolite | cas:138-08-9 | |
| Phosphate | Metabolite | cas:14265-44-2 | |
| Glucose-6P (open) | Metabolite | chebi:57584 | D-Glucose-6-Phosphate (2-) open form |
| Fructose 6P (open) | Metabolite | chebi:57579 | fructose-6-phosphate (2-) open form |
| CDC19 | GeneProduct | ensembl:YAL038W | pyruvate kinase 1 |
| TPI1 | GeneProduct | ensembl:YDR050C | |
| ERR1 | GeneProduct | ensembl:YOR393W | enolase: ERR1 |
| PFK2 | GeneProduct | ensembl:YMR205C | |
| GPM3 | GeneProduct | ensembl:YOL056W | |
| ENO2 | GeneProduct | ensembl:YHR174W | |
| FBA1 | GeneProduct | ensembl:YKL060C | |
| phosphopyruvate hydratase | GeneProduct | sgd:S000004942 | |
| PGK1 | GeneProduct | ensembl:YCR012W | 3-phophsoglycerate kinase |
| ENO1 | GeneProduct | ensembl:YGR254W | |
| TDH2 | GeneProduct | ensembl:YJR009C | glyceraldehyde 3-phosphate dehydrogenase 2 |
| PYK2 | GeneProduct | ensembl:YOR347C | pyruvate kinase 2 |
| TDH1 | GeneProduct | ensembl:YJL052W | glyceraldehyde 3-phosphate dehydrogenase 1 |
| PGI1 | GeneProduct | ensembl:YBR196C | glucose-6-phosphate isomerase |
| GPM1 | GeneProduct | ensembl:YKL152C | phosphoglycerate mutase 1 |
| PFK1 | GeneProduct | ensembl:YGR240C | |
| TDH3 | GeneProduct | ensembl:YGR192C | glyceraldehyde 3-phosphate dehydrogenase 3 |
| ERR2 | GeneProduct | ensembl:YPL281C | enolase: ERR2 |