Small ligand GPCRs (WP247)

Homo sapiens

G protein–coupled receptors (GPCRs) which are also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times. Source: [–coupled_receptor Wikipedia] These small ligand receptors are part of the Rhodopsin-like family of GPCRs. Source: [ Wikipedia]


Nathan Salomonis , Alex Pico , Kristina Hanspers , Egon Willighagen , and Eric Weitz


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Homo sapiens



Pathway Ontology

G protein mediated signaling pathway


Label Type Compact URI Comment
LysophosphatidicAcid Metabolite wikidata:Q2823281
Prostanoids Metabolite chebi:26347
Cannabinoid Metabolite chebi:67194
Melatonin Metabolite chebi:16796
MTNR1A GeneProduct ncbigene:4543
CNR2 GeneProduct ncbigene:1269
GPR50 GeneProduct ensembl:ENSG00000102195
PTGER1 GeneProduct ncbigene:5731
PTGER2 GeneProduct ncbigene:5732
EDG5 GeneProduct ncbigene:9294
PTGER4 GeneProduct ncbigene:5734
EDG3 GeneProduct ncbigene:1903
EDG1 GeneProduct ncbigene:1901
CNR1 GeneProduct ncbigene:1268
TBXA2R GeneProduct ncbigene:6915
PTAFR GeneProduct ncbigene:5724
EDG2 GeneProduct ncbigene:1902
PTGIR GeneProduct ncbigene:5739
PTGDR GeneProduct ncbigene:5729
PTGER3 GeneProduct ncbigene:5733
EDG6 GeneProduct ncbigene:8698
MTNR1B GeneProduct ncbigene:4544
PTGFR GeneProduct ncbigene:5737