Dopamine metabolism (WP2436)

Homo sapiens

Dopamine is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals. The dopamine system plays a central role in several significant medical conditions, including Parkinson's disease. Parkinson's disease is an age-related disorder characterized by movement disorders such as stiffness of the body, slowing of movement, and trembling of limbs when they are not in use. The main symptoms are caused by the loss of dopamine-secreting cells in the substantia nigra. These dopamine cells are especially vulnerable to damage, and a variety of insults, including encephalitis (as depicted in the book and movie "Awakenings"), repeated sports-related concussions, and some forms of chemical poisoning such as MPTP, can lead to substantial cell loss, producing a parkinsonian syndrome that is similar in its main features to Parkinson's disease. The most widely used treatment for parkinsonism is administration of L-DOPA, the metabolic precursor for dopamine. L-DOPA is converted to dopamine in the brain and various parts of the body by the enzyme DOPA decarboxylase. L-DOPA is used rather than dopamine itself because, unlike dopamine, it is capable of crossing the blood-brain barrier. Description source: [ Wikipedia] Proteins on this pathway have targeted assays available via the [ CPTAC Assay Portal]


Marek Ostaszewski , Egon Willighagen , Denise Slenter , Marvin Martens , Martina Summer-Kutmon , Andika Tan , and Kristina Hanspers


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Homo sapiens



Cell Type Ontology

dopaminergic neuron

Pathway Ontology

dopamine metabolic pathway classic metabolic pathway dopamine degradation pathway dopamine signaling pathway dopamine biosynthetic pathway


Label Type Compact URI Comment
iron(2+) Metabolite chebi:29033
FAD Metabolite hmdb:HMDB0001248
Dopamine Metabolite hmdb:HMDB0000073
Dopamine quinone Metabolite hmdb:HMDB0012219
Glutathione Metabolite hmdb:HMDB0000125
L-Dopa Metabolite hmdb:HMDB0000181
CO2 Metabolite hmdb:HMDB0001967
Leukoaminochrome Metabolite hmdb:HMDB0012992
Dopaminochrome Metabolite pubchem.compound:170262
L-Dopa quinone Metabolite chebi:16852
Leucodopachrome Metabolite hmdb:HMDB0004067
L-Dopachrome Metabolite hmdb:HMDB0001430
5,6-Dihydroxyindole Metabolite hmdb:HMDB0004058
DHICA Metabolite hmdb:HMDB0001253
ICQA Metabolite pubchem.compound:46173450
Neuromelanin Metabolite wikidata:Q1981297
L-Tyrosine Metabolite hmdb:HMDB0000158
Tetrahydrobiopterin Metabolite hmdb:HMDB0000027
4a-Hydroxytetrahydrobiopterin Metabolite hmdb:HMDB0002281
DOPAL Metabolite hmdb:HMDB0003791
3-Methoxytyramine Metabolite hmdb:HMDB0000022
ROS Metabolite chebi:26523
S-Adenosylhomocysteine Metabolite hmdb:HMDB0000939
1-chloro-2,4-dinitrobenzene Metabolite chebi:34718
S-Adenosylmethionine Metabolite hmdb:HMDB0001185
N-Methylserotonin Metabolite hmdb:HMDB0004369
H2O Metabolite hmdb:HMDB0002111
O2 Metabolite hmdb:HMDB0001377
H2O2 Metabolite hmdb:HMDB0003125
Ammonia Metabolite hmdb:HMDB0000051
FAD Metabolite hmdb:HMDB0001248
Homovanillin Metabolite hmdb:HMDB0005175
DOPET Metabolite hmdb:HMDB0005784
DOPAC Metabolite chebi:41941
Homovanillic acid Metabolite hmdb:HMDB0000118
TYR GeneProduct ncbigene:7299
SOD1 GeneProduct ncbigene:6647
DDC GeneProduct ncbigene:1644
DDC GeneProduct ncbigene:1644
NQO1 GeneProduct ncbigene:1728
TH GeneProduct ncbigene:7054
PRKACA GeneProduct ncbigene:5566
PRKACB GeneProduct ncbigene:5567
PRKACG GeneProduct ncbigene:5568
PPP2CA GeneProduct ncbigene:5515
PPP2CB GeneProduct ncbigene:5516
MAOA GeneProduct ncbigene:4128
COMT GeneProduct ncbigene:1312
MAOB GeneProduct ncbigene:4129


  1. Targeting heat shock proteins to modulate α-synuclein toxicity. Jones DR, Moussaud S, McLean P. Ther Adv Neurol Disord. 2014 Jan;7(1):33–51. PubMed Europe PMC Scholia